bioRxiv
Most Recent
Small (Weinheim an der Bergstrasse, Germany)
Complex Morphogenesis by a Model Intrinsically Disordered Protein
Plant science : an international journal of experimental plant biology
Review: F-Actin remodelling during plant signal transduction via biomolecular assembly
Methods in molecular biology (Clifton, NJ)
Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
These authors had a pretty stellar Nat Chem Biol paper showing how acetylation regulates phase separation last year. Now they're sharing their protocol--check it out!
The EMBO journal
SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs
bioRxiv
Biomolecular Condensation Drives Leukemia Caused by NUP98-Fusion Proteins
The journal of physical chemistry letters
Revealing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment
Jill Bouchard
Contributing editor, Condensates.com
No wonder IDPs are commonly found in condensates, their responsiveness must be at least part of why condensates are so sensitive to their environment.
bioRxiv
Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures
Nov
19
IDPSeminars: Wade Zeno & Shahar Sukenik — Nov 19
Thursday, November 19, 2020
Nature communications
Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes
Jill Bouchard
Contributing editor, Condensates.com
Here's a note to anyone studying condensate-loving IDPs: when highly charged species are involved, concentration can drastically change the kinetics of interactions.
Science Advances
Assembly of the algal CO 2-fixing organelle, the pyrenoid, is guided by a Rubisco-binding motif
Jill Bouchard
Contributing editor, Condensates.com
This paper is about the biochemistry underlying the complex core-shell architecture of my favorite condensate in plants/algae.
bioRxiv
Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation
Journal of chemical information and modeling
Different Force Fields Give Rise to Different Amyloid Aggregation Pathways in Molecular Dynamics Simulations
Jill Bouchard
Contributing editor, Condensates.com
If you're thinking about using molecular dynamics to investigate aggregation and amyloid formation from condensates, this paper provides some nice insights to consider beforehand.
Journal of the American Chemical Society
Folding of an Intrinsically Disordered Iron-Binding Peptide in Response to Sedimentation Revealed by Cryo-EM
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting new method to look at IDPs and minerals in solid formations. I wonder if it could be applied to more liquid- or gel-like condensates?
Biochemical Society transactions
Fuzzy protein theory for disordered proteins
Biochemical Society transactions
Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?
Jill Bouchard
Contributing editor, Condensates.com
This review covers how intrinsic disorder is involved in phase separation of both proteins and lipids at membrane interfaces.
bioRxiv
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Nov
20
IDPfun webinars: Cristina Marino-Buslje & Elizabeth Martinez-Perez — Nov 20
Friday, November 20, 2020
Proceedings of the National Academy of Sciences of the United States of America
Comparative roles of charge, π, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins
Nov
05
IDPSeminars: Aurelia Ball & Richard Kriwacki — Nov 5
Thursday, November 5, 2020