Nature chemical biology
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Neural regeneration research
Prion-like Domain Disease-Causing Mutations and Misregulation of Alternative Splicing Relevance in Limb-Girdle Muscular Dystrophy (LGMD) 1G
Soft matter
Phase Behaviour and Structure of a Model Biomolecular Condensate
Proceedings of the National Academy of Sciences of the United States of America
Phase Transition of RNA-protein Complexes Into Ordered Hollow Condensates
Jill Bouchard
Contributing editor, Condensates.com
So glad to see this work out! We really enjoyed getting a sneak peak at Priya Banerjee's Kitchen Table talk. I hope you'll enjoy the video and paper too!
Biochimica et biophysica acta Proteins and proteomics
Criticality in the Conformational Phase Transition Among Self-Similar Groups in Intrinsically Disordered Proteins: Probed by Salt-Bridge Dynamics
Jill Bouchard
Contributing editor, Condensates.com
This paper seems to take a different take on phase transitions than I'm used to seeing, but I imagine the interactions also play a role in LLPS transitions.
bioRxiv
SON and SRRM2 form nuclear speckles in human cells
Biochemistry Biokhimiia
The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization
bioRxiv
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Journal of medical virology
Subversion of Host Stress Granules by Coronaviruses: Potential Roles of π-rich Disordered Domains of Viral Nucleocapsids
Proteins
cnnAlpha: Protein Disordered Regions Prediction by Reduced Amino Acid Alphabets and Convolutional Neural Networks
Jill Bouchard
Contributing editor, Condensates.com
These authors put machine learning to work for predicting disordered regions. Have you tried it yet? It might turn out to be useful for new proteins found in condensates...
bioRxiv
A predictive coarse-grained model for position-specific effects of post-translational modifications on disordered protein phase separation
Jun
25
IDPSIG and friends Virtual Symposium
Thursday, June 25, 2020
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09
IDPSeminars: Samrat Mukhopadhyay & Norman Davey — July 9
Thursday, July 9, 2020
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23
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Thursday, July 23, 2020
Aug
06
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Thursday, August 6, 2020
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20
IDPSeminars: Allan Drummond & Keren Lasker — August 20
Thursday, August 20, 2020
Biotechnology advances
Protein Folding and Assembly in Confined Environments: Implications for Protein Aggregation in Hydrogels and Tissues
Jill Bouchard
Contributing editor, Condensates.com
Here's a review discussing how to use hydrogels to study proteins in a more native (possibly condensed) state.
Biophysical journal
Distance-Based Metrics for Comparing Conformational Ensembles of Intrinsically Disordered Proteins
Jill Bouchard
Contributing editor, Condensates.com
This method may also be useful to describe ensembles of proteins inside condensates, given that there's a good representation of part-structured part-disordered proteins there.
Journal of cell science
Proteomic Analysis Reveals the Direct Recruitment of Intrinsically Disordered Regions to Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
Here's a careful analysis of what proteins make up yeast stress granules to figure out why they form a less dynamic compartment than SGs in animals. Go figure, IDPs seem to play a major role.
Nature communications
Extent of N-terminus Exposure of Monomeric Alpha-Synuclein Determines Its Aggregation Propensity
Jill Bouchard
Contributing editor, Condensates.com
This is quite of thorough study of how small ions can affect the phase behaviors of proteins.