JPhysChemB virtual issue on Intrinsically Disordered Proteins

The journal of physical chemistry B

Conformational Characteristics and Phase Behavior of Intrinsically Disordered Proteins─Where Physical Chemistry Meets Biology

• Methods
• Neurodegeneration
• Phase Separation
• Physics of Condensates

Jill Bouchard

Editor in Chief, Condensates.com

This is the Preface article for the Journal of Physical Chemistry B's virtual issue on IDPS. Make sure to check out all the great papers with the JPhysChemB special issue tag.

The journal of physical chemistry B

Self-Diffusive Properties of the Intrinsically Disordered Protein Histatin 5 and the Impact of Crowding Thereon: A Combined Neutron Spectroscopy and Molecular Dynamics Simulation Study

• Methods
• Physics of Condensates

The journal of physical chemistry B

Examining the Ensembles of Amyloid-β Monomer Variants and Their Propensities to Form Fibers Using an Energy Landscape Visualization Method

• Methods
• Neurodegeneration
• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Conformational and Solvation Dynamics of an Amyloidogenic Intrinsically Disordered Domain of a Melanosomal Protein

• Methods
• Neurodegeneration
• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Aggregation and the Intrinsic Structural Disorder of Dipeptide Repeat Peptides of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Characterized by NMR

• Methods
• Neurodegeneration
• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Proline Isomerization Regulates the Phase Behavior of Elastin-Like Polypeptides in Water

• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Fluorescence Depolarization Kinetics Captures Short-Range Backbone Dihedral Rotations and Long-Range Correlated Dynamics of an Intrinsically Disordered Protein

• Neurodegeneration
• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Mechanistic Insights on ATP’s Role as a Hydrotrope

• Phase Separation
• Physics of Condensates

Jill Bouchard

Editor in Chief, Condensates.com

Find out how ATP, a solubilizer of hydrophobes, can interact with condensates in this paper.

The journal of physical chemistry B

Small-Angle X-ray Scattering Signatures of Conformational Heterogeneity and Homogeneity of Disordered Protein Ensembles

• Methods
• Physics of Condensates

The journal of physical chemistry B

Thermodynamic Compensation in Peptides Following Liquid-Liquid Phase Separation

• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Does Electric Friction Matter in Living Cells?

• Methods
• Physics of Condensates

The journal of physical chemistry B

A Simple Explicit-Solvent Model of Polyampholyte Phase Behaviors and Its Ramifications for Dielectric Effects in Biomolecular Condensates

• Methods
• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Quantitative Analysis of Protein Unfolded State Energetics: Experimental and Computational Studies Demonstrate That Non-Native Side-Chain Interactions Stabilize Local Native Backbone Structure

• Methods
• Physics of Condensates

The Journal of Physical Chemistry B

Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility

• Physics of Condensates

The journal of physical chemistry B

Biophysics of Phase Separation of Disordered Proteins Is Governed by Balance between Short- And Long-Range Interactions

• Methods
• Phase Separation
• Physics of Condensates

The journal of physical chemistry B

Structure and Dynamics of Ribonuclease A during Thermal Unfolding: The Failure of the Zimm Model

• Methods
• Physics of Condensates

The journal of physical chemistry B

Systematic Differences between Current Molecular Dynamics Force Fields To Represent Local Properties of Intrinsically Disordered Proteins

• Methods
• Neurodegeneration
• Physics of Condensates

Jill Bouchard

Editor in Chief, Condensates.com

Here's a helpful comparison of methods for simulating IDPs, using a couple of proteins that are very familiar to the condensate community.

The journal of physical chemistry B

Conformational Preferences of an Intrinsically Disordered Protein Domain: A Case Study for Modern Force Fields

• Methods
• Neurodegeneration
• Physics of Condensates

Jill Bouchard

Editor in Chief, Condensates.com

If you're in the market to find the best way to simulate a phase separating IDP, this should be a good resource.

The journal of physical chemistry B

The Effects of Chain Length on the Structural Properties of Intrinsically Disordered Proteins in Concentrated Solutions

• Methods
• Physics of Condensates

The journal of physical chemistry B

Molecular Details of Protein Condensates Probed by Microsecond Long Atomistic Simulations

• Methods
• Neurodegeneration
• Phase Separation
• Physics of Condensates