Proceedings of the National Academy of Sciences of the United States of America
Most Recent
Nature chemical biology
Formation and Functionalization of Membraneless Compartments in Escherichia Coli
Neural regeneration research
Prion-like Domain Disease-Causing Mutations and Misregulation of Alternative Splicing Relevance in Limb-Girdle Muscular Dystrophy (LGMD) 1G
Current topics in developmental biology
Organizing the Oocyte: RNA Localization Meets Phase Separation
Soft matter
Phase Behaviour and Structure of a Model Biomolecular Condensate
Langmuir : the ACS journal of surfaces and colloids
Fission and Internal Fusion of Protocell With Membraneless “Organelles” Formed by Liquid-Liquid Phase Separation
Jill Bouchard
Contributing editor, Condensates.com
Here's a strategy to create hierarchical protocells using phase separation and might give us insights into what early life looked like.
Scientific reports
Enhanced Protein Adsorption Upon Bulk Phase Separation
Molecular Biology of the Cell
Nuclear Body Phase Separation Drives Telomere Clustering in ALT Cancer Cells
eLife
SynGAP Isoforms Differentially Regulate Synaptic Plasticity and Dendritic Development
Jill Bouchard
Contributing editor, Condensates.com
It looks like the isoform that phase separates does something very different than the one that doesn't (go figure). Read on to find out how.
bioRxiv
Transcriptomic and proteomic regulation through abundant, dynamic, and independent arginine methylation by Type I and Type II PRMTs
Jill Bouchard
Contributing editor, Condensates.com
Here's a new method to look at Arg methylation, and the authors demonstrated an enrichment of it in LLPS.
Pharmaceuticals (Basel, Switzerland)
Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation
Jill Bouchard
Contributing editor, Condensates.com
This review collects various lines of evidence that suggest condensates containing proteasomal components form under stress.
Emerging topics in life sciences
Granule Regulation by Phase Separation During Drosophila Oogenesis
bioRxiv
Fusion Speed of Biomolecular Condensates
Current opinion in virology
Structure, Dynamics and Phase Separation of Measles Virus RNA Replication Machinery
Proceedings of the National Academy of Sciences of the United States of America
Phase Transition of RNA-protein Complexes Into Ordered Hollow Condensates
Jill Bouchard
Contributing editor, Condensates.com
So glad to see this work out! We really enjoyed getting a sneak peak at Priya Banerjee's Kitchen Table talk. I hope you'll enjoy the video and paper too!
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
A Proposed Role for the SARS-CoV-2 Nucleocapsid Protein in the Formation and Regulation of Biomolecular Condensates
Proceedings of the National Academy of Sciences of the United States of America
Primordial Emergence of a Nucleic Acid-Binding Protein via Phase Separation and Statistical Ornithine-To-Arginine Conversion
Jill Bouchard
Contributing editor, Condensates.com
It's cool that the authors think "function evolved from phase separation" of the most primal biomolecules.
Biochemistry Biokhimiia
The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization
Developmental cell
CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting paper on what controls the size of HLBs. Does a similar mechanism control other condensates?
bioRxiv