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Most Recent
PloS one
Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity
bioRxiv
The SARS-CoV-2 nucleocapsid protein preferentially binds long and structured RNAs
Proceedings of the National Academy of Sciences of the United States of America
Distinct roles of hnRNPH1 low-complexity domains in splicing and transcription
The journal of physical chemistry B
Evolution of CPEB4 Dynamics Across its Liquid-Liquid Phase Separation Transition
Cellular & molecular biology letters
The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression
Jill Bouchard
Managing editor, Condensates.com
These authors showed that the LC domains drove the formation of condensates involved in epigenetically stimulating the expression of genes in cancer cells.
Nature structural & molecular biology
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads
Molecular and cellular biology
The RNA helicase Ded1 regulates translation and granule formation during multiple phases of cellular stress responses
Jan
09
WITHDRAWN: Gordon Research Conference: Protein Folding Dynamics–Folding and Misfolding: Effects of Evolution and Environment (GRC)
Sunday, January 9, 2022 | Oxnard, CA, United States
RNA
How do protein domains of low sequence complexity work?
Jill Bouchard
Managing editor, Condensates.com
This review covers the role of low complexity domains in phase separation.
Proceedings of the National Academy of Sciences of the United States of America
The low-complexity domain of the FUS RNA binding protein self-assembles via the mutually exclusive use of two distinct cross-β cores
bioRxiv
Intermolecular reorganisation of single-component condensates during ageing promotes multiphase architectures.
bioRxiv
Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity
Jill Bouchard
Managing editor, Condensates.com
Have you seen polyQ regions in proteins recently? This work shows polyQ can increase a protein's phase separation propensity.
The Journal of chemical physics
Salt dependent phase behavior of intrinsically disordered proteins from a coarse-grained model with explicit water and ions
Journal of visualized experiments : JoVE
Single-molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
Viruses
Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments
Cell
The expanding amyloid family: Structure, stability, function, and pathogenesis
The Journal of biological chemistry
Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment (LARKS) structural motif in amyloid-like fibrils
Kitchen Table Talk
Must ReadVIDEO: Keren Lasker on Biomolecular Condensates in Bacteria: Mechanisms and Synthetic Biology
Aug
31
Condensate Colloquium Series: Tanja Mittag & Alex Holehouse — August 31
Tuesday, August 31, 2021