Kitchen Table Talk
Must ReadMost Recent
Aug
31
Condensate Colloquium Series: Tanja Mittag & Alex Holehouse — August 31
Tuesday, August 31, 2021
Biomolecules
The Role of Methionine Residues in the Regulation of Liquid-Liquid Phase Separation
bioRxiv
Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription
Trends in Biochemical Sciences
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?
Jill Bouchard
Managing editor, Condensates.com
One way PTMs accelerate disease is by altering phase separation. Read further for the details...
International journal of molecular sciences
The Different Faces of the TDP-43 Low-Complexity Domain: The Formation of Liquid Droplets and Amyloid Fibrils
bioRxiv
The Low Complexity Domain of the FUS RNA Binding Protein Self-assembles via the Mutually Exclusive Use of Two Distinct Cross-β Cores
Journal of the American Chemical Society
O-Linked- N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics
Brain research
Disease-associated mutations affect TIA1 phase separation and aggregation in a proline-dependent manner
Journal of cell science
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
DNA repair
Biomolecular condensates at sites of DNA damage: More than just a phase
Journal of the American Chemical Society
Different Folding States from the Same Protein Sequence Determine Reversible vs Irreversible Amyloid Fate
Jill Bouchard
Managing editor, Condensates.com
This work argues amyloids can be reversible and irreversible.
Frontiers in molecular biosciences
Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis
The Journal of biological chemistry
The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism
Jill Bouchard
Managing editor, Condensates.com
It looks like this disease might happen through a condensate mechanism.
Kitchen Table Talk
Must ReadVIDEO: Shahar Sukenik on Turning Protein Disorder into Function: Is the Solution the Solution?
Frontiers in molecular biosciences
A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation
Journal of cell science
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
Chemical science
Sequestration within biomolecular condensates inhibits Aβ-42 amyloid formation
World journal of stem cells
Low complexity domains, condensates, and stem cell pluripotency
Protein science : a publication of the Protein Society