bioRxiv
Most Recent
Apr
29
IDPSeminars: Anand Srivastava & Katherine Stott — April 29
Thursday, April 29, 2021
bioRxiv
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
Jill Bouchard
Managing editor, Condensates.com
Nice–designing peptide inhibitors that target the zipper driving phase separation may be an option for therapeutic intervention.
BioRxiv
SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence
Jill Bouchard
Managing editor, Condensates.com
QLC is a very catchy name for glutamine-rich low complexity sequence. And I bet the idea of pH regulation carries over to other QLCs in condensates.
bioRxiv
Identification of the Rigid Core for Aged Liquid Droplets of the TDP-43 Low Complexity Domain
bioRxiv
Dynamic arrest and aging of biomolecular condensates are regulated by low-complexity domains, RNA and biochemical activity
Proceedings of the National Academy of Sciences of the United States of America
Transiently structured head domains control intermediate filament assembly
Jill Bouchard
Managing editor, Condensates.com
Here's some more work out of the McKnight lab about how beta secondary structures lead to phase separation.
bioRxiv
Droplet and fibril formation of the functional amyloid Orb2
Biophysical journal
Real-Time Observation of Structure and Dynamics during the Liquid-to-Solid Transition of FUS LC
The FEBS journal
Aberrant phase separation and cancer
Nucleic acids research
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
Proteins
Thermodynamic stability of hnRNP A1 low complexity domain revealed by high-pressure NMR
Protein science : a publication of the Protein Society
N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein FUS
International journal of molecular sciences
From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies
Biophysical journal
The key role of solvent in condensation: mapping water in liquid-liquid phase-separated FUS
Science advances
CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome
Jill Bouchard
Managing editor, Condensates.com
This protein phase separates, and the CGG99 RNA accelerates a liq-sol transition... not surprising that behavior is tied to neurodegeneration.
Current opinion in genetics & development
Redox-mediated regulation of low complexity domain self-association
Jill Bouchard
Managing editor, Condensates.com
Here's a review discussing the molecular mechanisms of liquid and gel phases of certain low complexity domains.
The EMBO journal
ZSP-1 is a Z granule surface protein required for Z granule fluidity and germline immortality in Caenorhabditis elegans
bioRxiv
Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains
bioRxiv