Neural regeneration research
Most Recent
Nature
LEM2 Phase Separation Promotes ESCRT-mediated Nuclear Envelope Reformation
Molecular neurodegeneration
Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review integrating all the recent advancements in neurodegeneration studies (including how condensates play a role).
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
Database
PlaToLoCo
Nucleic acids research
PlaToLoCo: The First Web Meta-Server for Visualization and Annotation of Low Complexity Regions in Proteins
Jill Bouchard
Contributing editor, Condensates.com
Do you have a phase-separating protein that looks like it may have an LCD? You can use this online platform to check into it.I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/platoloco/
bioRxiv
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
bioRxiv
The low complexity motif of cytoplasmic polyadenylation element binding protein 3 (CPEB3) is critical for the trafficking of its targets in neurons
Jill Bouchard
Contributing editor, Condensates.com
Isn't it cool that the low complexity domain is required for P-body localization and affects long term memory?!
Nucleic acids research
RPS28B mRNA Acts as a Scaffold Promoting Cis-Translational Interaction of Proteins Driving P-body Assembly
Jill Bouchard
Contributing editor, Condensates.com
This paper shows quite an intricate interaction between an mRNA and the protein it encodes (and another) driving P-body formation.
bioRxiv
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
Kitchen Table Talk
Tatjana Trcek on Germ Granule mRNA Self-Assembly
Molecules (Basel, Switzerland)
Disordered Residues and Patterns in the Protein Data Bank
Frontiers in chemistry
NMR Structure and Dynamics of TonB Investigated by Scar-Less Segmental Isotopic Labeling Using a Salt-Inducible Split Intein
Jill Bouchard
Contributing editor, Condensates.com
This could be a useful method to study the effects of domains in modular proteins known to phase separate.
Angewandte Chemie (International ed in English)
Adaptive Chemo-Enzymatic Microreactors Composed of Inorganic Nanoparticles and Bio-Inspired Intrinsically Disordered Proteins
Jill Bouchard
Contributing editor, Condensates.com
IDPs + nanoparticles = so many possibilities for controlling condensates!
Jan
28
Biomolecular Condensates in Cancer
Thursday, January 28, 2021 | Pacific Grove, CA, United States
Kitchen Table Talk
Rohit Pappu on Stickers and Spacers
PLoS computational biology
Atypical structural tendencies among low-complexity domains in the protein data bank proteome
Nucleic acids research
LLPSDB: a database of proteins undergoing liquid-liquid phase separation in vitro
Jill Bouchard
Contributing editor, Condensates.com
This is #1/4 condensate-related database featured in the 2020 Nucleic Acids Database Issue. I like that this database highlights the experimental conditions of in vitro phase separation. Have you looked up your pet protein yet?I've saved it in our library of Resources--check it out here: https://condensates.com/resources/llpsdb/
Neuron
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
ACS nano