Here's a Journal Club article about the biophysical characteristics of misguided condensates. It covers the recent Nat Cell Biol paper about AKAP95 condensates.

Nature Reviews Molecular Cell Biology

The curious behaviour of poly(A) RNA

Jill Bouchard

Editor in Chief, Condensates.com

Here's a nice Journal Club article about RNA phase separation.

Nature chemical biology

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

Must Read

Nature cell biology

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis

For Beginners

Must Read

Nature reviews Molecular cell biology

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Nature communications

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Nature structural & molecular biology

Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression

Must Read

Nature

Wetting regulates autophagy of phase-separated compartments and the cytosol

Must Read

Nature Neuroscience

Mesophasic organization of GABA A receptors in hippocampal inhibitory synapses

Must Read

Nature Chemistry

Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells

Nature Communications

Condensation of Rubisco into a proto-pyrenoid in higher plant chloroplasts

Phase Separation

Must Read

Nature Cell Biology

Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis

Nature communications

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

Must Read

Nature Plants

The structural basis of Rubisco phase separation in the pyrenoid

Must Read

Nature

Nature’s Focus on Phase Separation in Biology

The role of ordered cooperative assembly in biomolecular condensates

Nuclear compartmentalization as a mechanism of quantitative control of gene expression

RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?

The STING phase-separator suppresses innate immune signalling

Mapping from sequence to droplets

Jill Bouchard

Spot in a drop: mutations in aberrant condensates

Jill Bouchard

The curious behaviour of poly(A) RNA

Jill Bouchard

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression

Wetting regulates autophagy of phase-separated compartments and the cytosol

Mesophasic organization of GABA A receptors in hippocampal inhibitory synapses

Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells

Condensation of Rubisco into a proto-pyrenoid in higher plant chloroplasts

Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

The structural basis of Rubisco phase separation in the pyrenoid

Assembly of synaptic active zones requires phase separation of scaffold molecules

Expert in Biomolecular Condensates for The Development of Novel Drugs

Interested in joining Dewpoint Boston?

Interested in joining Dewpoint Dresden?