Cells
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Cell
Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin
Jill Bouchard
Contributing editor, Condensates.com
Here's a bright shiny new imaging technique to help in the quest to study chromosome-containing condensates.
Kitchen Table Talk
Must ReadRohit Pappu on Molecular Grammar of Condensates – Part 3
Aging cell
Lamin A safeguards the m 6 A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence
Jill Bouchard
Contributing editor, Condensates.com
Here's an article about an interaction inside nuclear speckles that has interesting implications for the aging process.
BioEssays : news and reviews in molecular, cellular and developmental biology
Speculating on the Roles of Nuclear Speckles: How RNA-Protein Nuclear Assemblies Affect Gene Expression
Cell death & disease
Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies
Jill Bouchard
Contributing editor, Condensates.com
Interesting--an lncRNA "hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles." Looks like paraspeckles aren't the only speckle condensate with close ties to lncRNA.
Trends in biochemical sciences
Biomolecular Condensates in the Nucleus
Jill Bouchard
Contributing editor, Condensates.com
Need an update on what's new with nuclear condensates? This will be a good place to start!
Nature communications
HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
Jill Bouchard
Contributing editor, Condensates.com
It looks like HIV hits nuclear speckles hard in order to get into the host genome.
The EMBO journal
Trnp1 Organizes Diverse Nuclear Membrane-Less Compartments in Neural Stem Cells
The Journal of cell biology
Tyramide Signal Amplification Mass Spectrometry (TSA-MS) Ratio Identifies Nuclear Speckle Proteins
Plant physiology
An SMU Splicing Factor Complex Within Nuclear Speckles Contributes to Magnesium Homeostasis in Arabidopsis Thaliana
Jill Bouchard
Contributing editor, Condensates.com
What makes proteins involved in RNA metabolism localize to nuclear speckles? And what exactly do they do there? Read within to find out.
bioRxiv
SON and SRRM2 form nuclear speckles in human cells
Biochemistry Biokhimiia
The Role of Liquid-Liquid Phase Separation in the Compartmentalization of Cell Nucleus and Spatial Genome Organization
Oncogenesis
USP42 Enhances Homologous Recombination Repair by Promoting R-loop Resolution With a DNA-RNA Helicase DHX9
Jill Bouchard
Contributing editor, Condensates.com
This work investigates the link between DNA repair and nuclear speckles.
Molecular neurodegeneration
Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review integrating all the recent advancements in neurodegeneration studies (including how condensates play a role).
PLoS pathogens
RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia
Jill Bouchard
Contributing editor, Condensates.com
Interesting stuff: These authors show that upon infection of a leukemia-linked retrovirus, important DNA repair enzymes get sequestered away in Tax speckle structures, which leads to further genomic instability in leukemia cells.
Cells
Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome
Jill Bouchard
Contributing editor, Condensates.com
Who knew that lipids made it into nuclear condensates?!
Theranostics
Discrete Functional and Mechanistic Roles of Chromodomain Y-like 2 (CDYL2) Transcript Variants in Breast Cancer Growth and Metastasis
Jill Bouchard
Contributing editor, Condensates.com
It looks like certain isoforms of the CDYL2 protein stick to condensates in breast cancer cells affecting proliferation, migration and invasion.
Kitchen Table Talk
Priya Banerjee on Phase Transition and Hollow Condensates
PLoS genetics
Mutations in SPATA13/ASEF2 Cause Primary Angle Closure Glaucoma
Jill Bouchard
Contributing editor, Condensates.com
It looks like nuclear speckles might be implicated in glaucoma. Interested in learning more about it?