Frontiers in plant science
Most Recent
Nature communications
Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Nucleic acids research
SRRM2 organizes splicing condensates to regulate alternative splicing
Proceedings of the National Academy of Sciences of the United States of America
Long-distance association of topological boundaries through nuclear condensates
International journal of molecular sciences
The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein
Computational and structural biotechnology journal
Chromatin Hubs: A biological and computational outlook
Jill Bouchard
Editor in Chief, Condensates.com
This is a really nice review that covers all the ways many condensates are involved in chromatin hubs and transcription. Plus it lists a bunch of methods that may be helpful to investigate this relationship further!
Cell reports
Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus
Scientific reports
The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton
Frontiers in genetics
It’s Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control
Journal of cell science
Nuclear speckles – a driving force in gene expression
bioRxiv
SRRM2 organizes splicing condensates to regulate alternative splicing
Nature communications
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing
Cells
The Association of MEG3 lncRNA with Nuclear Speckles in Living Cells
Proceedings of the National Academy of Sciences of the United States of America
Nuclear speckle integrity and function require TAO2 kinase
bioRxiv
Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Array
Must ReadVIDEO: Emma Lundberg on Mapping the Spatiotemporal Proteome Architecture of Human Cells
Biology open
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes
Jul
24
FASEB Science Research Conference–The Nuclear Bodies Conference: Hubs of Genomic Activity (2022)
Sunday, July 24, 2022 | Western Shore, MA, Canada
bioRxiv
Topology of gene regulatory compartments relative to the nuclear matrix
Nature cell biology
Cell cycle-specific phase separation regulated by protein charge blockiness
Sidharth Sirdeshmukh
Research Associate, Dewpoint
The general idea is that the patterns of charge differences in proteins will influence the kinetics of their phase separation-guided reassembly. Charge blocks are stretches of amino acids with similar charge, and ‘blockiness’ is the alternation of blocks of opposite charge (+/-). If we make these blocks shorter, then droplet formation is impeded, and droplets that previously existed dissolve/ diffuse. Hyperphosphorylation during mitosis, lengthens the blocks, which encourages droplet formation. Tuning the lengths, the total number, sequence, and likely stochasticity of these kinds of blocks will likely result in favorable LLPS dynamics/ arrangements for diseases with known condensate MOA.