Epigenetics & chromatin
Most Recent
Molecular therapy oncolytics
hnRNPK-derived cell-penetratingpeptide inhibits cancer cell survival
BioRxiv
Genome Compartmentalization with Nuclear Landmarks: Random yet Precise
Communications biology
Speckles and paraspeckles coordinate to regulate HSV-1 genes transcription
bioRxiv
Hysteresis in PIF4 and ELF3 dynamics dominates warm daytime memory in Arabidopsis
Molecular neurodegeneration
Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing
Nucleic acids research
ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation
mBio
The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus
Jill Bouchard
Managing editor, Condensates.com
This paper shows an interesting interaction between a virus and nuclear speckles.
bioRxiv
Arg-tRNA synthetase links inflammatory metabolism to RNA splicing via nuclear condensates
Cold Spring Harbor perspectives in biology
Nuclear Compartments: An Incomplete Primer to Nuclear Compartments, Bodies, and Genome Organization Relative to Nuclear Architecture
BioRxiv
RNA is required for the maintenance of multiple cytoplasmic and nuclear membrane-less organelles
eLife
Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing
Jill Bouchard
Managing editor, Condensates.com
ACBs, could they be the newest membraneless organelle on the block?
Nature communications
Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging
Nature communications
High-depth spatial transcriptome analysis by photo-isolation chemistry
Jill Bouchard
Managing editor, Condensates.com
This looks to be a useful new method to detect genes expressed in condensates.
The FEBS journal
Nuclear speckles: dynamic hubs of gene expression regulation
Nature neuroscience
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain
Frontiers in cell and developmental biology
Emerging Roles of Liquid-Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling
Acta neuropathologica communications
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease
Nucleic acids research
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
Jill Bouchard
Managing editor, Condensates.com
This data led the authors to propose that SANS drives phase separation of nuclear speckles; I'm sure they're already working out the details.
Journal of cell science