Nucleic acids research
Most Recent
International journal of molecular sciences
RNA-Binding Proteins and the Complex Pathophysiology of ALS
Jill Bouchard
Managing editor, Condensates.com
Here's a nice review about the role of mutations in RNA-binding proteins that causes dysfunction of various membraneless organelles.
bioRxiv
An improved molecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under pathological conditions.
Kitchen Table Talk
Must ReadVIDEO: Shana Elbaum-Garfinkle on Emergent Material Properties of Biomolecular Condensates
bioRxiv
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Jill Bouchard
Managing editor, Condensates.com
Not only is this a really cool method at the intersection of proteomics and imaging, the database if full of amazing pictures!
bioRxiv
Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Cell Stress & Chaperones
Protein products of nonstop mRNA disrupt nucleolar homeostasis
Molecular Biology of the Cell
Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription
Jill Bouchard
Managing editor, Condensates.com
It looks like nucleoli are intertwined in cell cycle regulation in ways we are just beginning to understand.
Nature communications
Properties of repression condensates in living Ciona embryos
Biochemical and Biophysical Research Communications
The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ
Jill Bouchard
Managing editor, Condensates.com
It looks like there's a complex relationship between ribosomal DNA (rDNA) and nucleolar proteins when nuclear material gets degraded.
International journal of molecular sciences
G-Quadruplex Structures Colocalize with Transcription Factories and Nuclear Speckles Surrounded by Acetylated and Dimethylated Histones H3
Jill Bouchard
Managing editor, Condensates.com
If you want to know which condensates are associated with G-quads, this is a good study to peruse.
bioRxiv
Chromatin Network Retards Droplet Coalescence
Acta Neuropathologica Communications
Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization
bioRxiv
The cohesin regulator Stag1 promotes cell plasticity through heterochromatin regulation
Jill Bouchard
Managing editor, Condensates.com
It looks like this paper has identified a new regulator of certain condensates, with big implications for disease too.
Experimental cell research
Cellular metabolic stress responses via organelles
Jill Bouchard
Managing editor, Condensates.com
This review covers both membrane-bound and membraneless organelles.
Molecular cell
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
Nucleic acid therapeutics
Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective
Kitchen Table Talk
Must ReadVIDEO: Serena Sanulli on Chromatin and its Phases
bioRxiv
dSCOPE: a software to detect sequences critical for liquid-liquid phase separation
International journal of molecular sciences
Nuclear Reorganization in Hippocampal Granule Cell Neurons from a Mouse Model of Down Syndrome: Changes in Chromatin Configuration, Nucleoli and Cajal Bodies
Jill Bouchard
Managing editor, Condensates.com
Here are some interesting effects of Down Syndrome on a couple condensates.