eLife
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Emerging topics in life sciences
The Multiscale and Multiphase Organization of the Transcriptome
Jill Bouchard
Contributing editor, Condensates.com
Not every condensate is liquid: This review covers all the different phases used to organize the transcriptome.
Development (Cambridge, England)
mRNA Localization Is Linked to Translation Regulation in the Caenorhabditis elegans Germ Lineage
Jill Bouchard
Contributing editor, Condensates.com
Why are mRNA directed to germ granules? Read further to find out.
Scientific reports
EXOSC9 Depletion Attenuates P-body Formation, Stress Resistance, and Tumorigenicity of Cancer Cells
Jill Bouchard
Contributing editor, Condensates.com
This paper connects a component of the RNA exosome complex to P-body formation and suggests intervening therapeutically as a potential cancer treatment.
RNA (New York, NY)
Pat1 Increases the Range of Decay Factors and RNA Bound by the Lsm1-7 Complex
Jill Bouchard
Contributing editor, Condensates.com
This is another example of regulation by the phase separation of multivalent protein interactions.
Cold Spring Harbor symposia on quantitative biology
RNP Granule Formation: Lessons From P-Bodies and Stress Granules
Nature plants
DHH1/DDX6-like RNA Helicases Maintain Ephemeral Half-Lives of Stress-Response mRNAs
Trends in biochemical sciences
Mechanisms and Regulation of RNA Condensation in RNP Granule Formation
BioRxiv
A localization screen reveals translation factories and widespread co-translational RNA targeting
BioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
Biochemical and biophysical research communications
AtC3H18L Is a Stop-Codon Read-Through Gene and Encodes a Novel Non-Tandem CCCH Zinc-Finger Protein That Can Form Cytoplasmic Foci Similar to mRNP Granules
Jill Bouchard
Contributing editor, Condensates.com
Here's a new plant protein that localizes to condensates along the cytoskeleton....they seem to be similar to stress granules and P-bodies.
bioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
Wiley interdisciplinary reviews RNA
Phase-separated Bacterial Ribonucleoprotein Bodies Organize mRNA Decay
Nature Methods
Cell Biology Befriends Soft Matter Physics
BioRxiv
Integrated multi-omics reveals common properties underlying stress granule and P-body formation
3 funded PhD positions on the Role of phase separation mechanisms in higher-order chromatin organization during development
Université de Montpellier | Montpellier, France
ApplybioRxiv
Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis
Jill Bouchard
Contributing editor, Condensates.com
It's cool how condensates like stress granules and P-bodies play a role in the circadian rhythm. Check it out!
bioRxiv
The low complexity motif of cytoplasmic polyadenylation element binding protein 3 (CPEB3) is critical for the trafficking of its targets in neurons
Jill Bouchard
Contributing editor, Condensates.com
Isn't it cool that the low complexity domain is required for P-body localization and affects long term memory?!
Nature
Composition-dependent Thermodynamics of Intracellular Phase Separation
Nucleic acids research
RPS28B mRNA Acts as a Scaffold Promoting Cis-Translational Interaction of Proteins Driving P-body Assembly
Jill Bouchard
Contributing editor, Condensates.com
This paper shows quite an intricate interaction between an mRNA and the protein it encodes (and another) driving P-body formation.