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Journal of cell science
Amyloid Beta oligomers prevents Lysosomal targeting of miRNP to stop its recycling and target repression in glial cells
Jill Bouchard
Managing editor, Condensates.com
P bodies play a pretty interesting role in this process. Check out the paper for all the details.
EMBO reports
Dynamic subcellular compartmentalization ensures fidelity of piRNA biogenesis in silkworms
Jill Bouchard
Managing editor, Condensates.com
It looks like there's a very specific handoff of PIWI-interacting RNAs and PIWI proteins between 2 condensates to make sure a cell stays fertile.
The journal of physical chemistry B
Effect of RNA on Morphology and Dynamics of Membraneless Organelles
bioRxiv
A spoonful of disorder regulates interactions within Stress Granules and Processing Bodies
FEBS open bio
Do polyproline II helix associations modulate biomolecular condensates?
RNA (New York, NY)
The role of stress-activated RNA-protein granules in surviving adversity
Jill Bouchard
Managing editor, Condensates.com
This chapter covers how phase separation is involved in the formation of both P bodies and stress granules.
Frontiers in molecular biosciences
RNAs as Regulators of Cellular Matchmaking
Angewandte Chemie (International ed in English)
Electrochemical measurements reveal reactive oxygen species in stress granules
bioRxiv
Effect of RNA on morphology and dynamics of membraneless organelles.
Kitchen Table Talk
Must ReadVIDEO: Shana Elbaum-Garfinkle on Emergent Material Properties of Biomolecular Condensates
Nature chemical biology
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation
bioRxiv
Rice MEL2 regulates the timing of meiotic transition as a component of cytoplasmic RNA granules
Jill Bouchard
Managing editor, Condensates.com
Here's a conserved plant protein that seems to be important for regulating both P bodies and stress granules. I wonder if it's a scaffold or a client?
bioRxiv
The arrested state of processing bodies supports mRNA regulation in early development
Cell reports
High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes
The FEBS journal
Biological implications of decapping: beyond bulk mRNA decay
Jill Bouchard
Managing editor, Condensates.com
Here's a review discussing the intricate interaction between P bodies and RNA metabolism.
Physical chemistry chemical physics : PCCP
Liquid droplets of protein LAF1 provide a vehicle to regulate storage of the signaling protein K-Ras4B and its transport to the lipid membrane
bioRxiv
The Orb6-Sts5 Axis Regulates Stress Granule Formation and Heat Stress Response in Fission Yeast
Jill Bouchard
Managing editor, Condensates.com
This paper reports a new role for a kinase controlling cell growth--it looks like it also modulates the nucleation of stress granules upon various stress conditions.
bioRxiv
Dynamic arrest and aging of biomolecular condensates are regulated by low-complexity domains, RNA and biochemical activity
Frontiers in cell and developmental biology
Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner
Jill Bouchard
Managing editor, Condensates.com
This paper reveals a new connection between P bodies and cancer via the sequestration of LIN28A mRNA.