This review argues p53 is not a prion based on current data, even though it may form amyloid fibers. I bet this has something to do with it's phase separation properties which lead to aggregation.

Proceedings of the National Academy of Sciences of the United States of America

Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation

Phase Separation

Proceedings of the National Academy of Sciences of the United States of America

Michler’s hydrol blue elucidates structural differences in prion strains

Jill Bouchard

Editor in Chief, Condensates.com

Do you need a more sensitive dye to study liquid-to-solid phase transitions? This may do the trick.

Biomolecules

Intrinsically Disordered Proteins: Insights from Poincaré, Waddington, and Lamarck

Phase Separation

Jill Bouchard

Editor in Chief, Condensates.com

This review covers recent work showing how IDPs with prion-like properties drive new traits and adaptive opportunities in cells via phase separation.

Molecular plant

Heat makes cellular hotspots in plants

Jill Bouchard

Editor in Chief, Condensates.com

If you'd like to learn all about how plants use temperature-sensitive phase separation, read this.

Nucleic acids research

RNA-binding and prion domains: the Yin and Yang of phase separation

Aug

26

Proteostasis Consortium: Jim Shorter

Wednesday, August 26, 2020

Prion domains

In Vitro Characterization of Protein:Nucleic Acid Liquid-Liquid Phase Separation by Microscopy Methods and Nanoparticle Tracking Analysis

IDPSeminars: Ioana M. Ilie & Jeremy Schmit — September 1

Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation

Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation

An intrinsically disordered pathological prion variant Y145Stop converts into self-seeding amyloids via liquid-liquid phase separation

Spatiotemporal Modulations in Heterotypic Condensates of Prion and α-Synuclein Control Phase Transitions and Amyloid Conversion

Prion-Like Proteins in Phase Separation and Their Link to Disease

The N-terminal domain of the prion protein is required and sufficient for liquid-liquid phase separation; a crucial role of the Aβ-binding domain

Ultrasensitive Characterization of the Prion Protein by Surface-Enhanced Raman Scattering: Selective Enhancement via Electrostatic Tethering of the Intrinsically Disordered Domain with Functionalized Silver Nanoparticles

Jill Bouchard

Liquid-liquid phase separation of full-length prion protein initiates conformational conversion in vitro

Mechanistic inferences from analysis of measurements of protein phase transitions in live cells

From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies

The interplay between a GC-rich oligonucleotide and copper ions on prion protein conformational and phase transitions

p53, A Victim of the Prion Fashion

Jill Bouchard

Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation

Michler’s hydrol blue elucidates structural differences in prion strains

Jill Bouchard

Intrinsically Disordered Proteins: Insights from Poincaré, Waddington, and Lamarck

Jill Bouchard

Heat makes cellular hotspots in plants

Jill Bouchard

RNA-binding and prion domains: the Yin and Yang of phase separation

Proteostasis Consortium: Jim Shorter

Senior Manager, Lab Operations and Facilities / Safety Officer (m/f/d)

Head of Translational (Preclinical) Pharmacology – Neurobiology

Head of Translational (Preclinical) Pharmacology – Oncology