Current opinion in structural biology
Most Recent
Journal of molecular biology
Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation
Proceedings of the National Academy of Sciences of the United States of America
An intrinsically disordered pathological prion variant Y145Stop converts into self-seeding amyloids via liquid-liquid phase separation
bioRxiv
Spatiotemporal Modulations in Heterotypic Condensates of Prion and α-Synuclein Control Phase Transitions and Amyloid Conversion
Biomolecules
Prion-Like Proteins in Phase Separation and Their Link to Disease
The Journal of biological chemistry
The N-terminal domain of the prion protein is required and sufficient for liquid-liquid phase separation; a crucial role of the Aβ-binding domain
Journal of Physical Chemistry Letters
Ultrasensitive Characterization of the Prion Protein by Surface-Enhanced Raman Scattering: Selective Enhancement via Electrostatic Tethering of the Intrinsically Disordered Domain with Functionalized Silver Nanoparticles
Jill Bouchard
Editor in Chief, Condensates.com
Here's a new way to look at the dilute phase of your favorite phase separating IDP.
The Journal of biological chemistry
Liquid-liquid phase separation of full-length prion protein initiates conformational conversion in vitro
Journal of molecular biology
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
International journal of molecular sciences
From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies
International journal of biological macromolecules
The interplay between a GC-rich oligonucleotide and copper ions on prion protein conformational and phase transitions
Cancers
p53, A Victim of the Prion Fashion
Jill Bouchard
Editor in Chief, Condensates.com
This review argues p53 is not a prion based on current data, even though it may form amyloid fibers. I bet this has something to do with it's phase separation properties which lead to aggregation.
Proceedings of the National Academy of Sciences of the United States of America
Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation
Proceedings of the National Academy of Sciences of the United States of America
Michler’s hydrol blue elucidates structural differences in prion strains
Jill Bouchard
Editor in Chief, Condensates.com
Do you need a more sensitive dye to study liquid-to-solid phase transitions? This may do the trick.
Biomolecules
Intrinsically Disordered Proteins: Insights from Poincaré, Waddington, and Lamarck
Jill Bouchard
Editor in Chief, Condensates.com
This review covers recent work showing how IDPs with prion-like properties drive new traits and adaptive opportunities in cells via phase separation.
Molecular plant
Heat makes cellular hotspots in plants
Jill Bouchard
Editor in Chief, Condensates.com
If you'd like to learn all about how plants use temperature-sensitive phase separation, read this.
Nucleic acids research
RNA-binding and prion domains: the Yin and Yang of phase separation
Aug
26
Proteostasis Consortium: Jim Shorter
Wednesday, August 26, 2020
Array
Must ReadVIDEO: Rohit Pappu on Molecular Grammar of Condensates – Part 2
Prion