Nucleic acids research
Most Recent
Current opinion in cell biology
Moving beyond disease to function: Physiological roles for polyglutamine-rich sequences in cell decisions
Nature communications
Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
Journal of molecular biology
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
International journal of molecular sciences
From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies
Science advances
CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome
Jill Bouchard
Contributing editor, Condensates.com
This protein phase separates, and the CGG99 RNA accelerates a liq-sol transition... not surprising that behavior is tied to neurodegeneration.
Molecular biology and evolution
The hunt for ancient prions: Archaeal prion-like domains form amyloid-based epigenetic elements
Jill Bouchard
Contributing editor, Condensates.com
Interesting, I wonder if any of the archaeal prion candidates they found have complex phase diagrams.
Biophysical journal
Mechanics of a molecular mousetrap– nucleation-limited innate immune signaling
Jill Bouchard
Contributing editor, Condensates.com
Which phase fits the current data on immune signaling best--crystalline or liquid? Read further to find out what these authors think.
Current opinion in cell biology
Phosphorylation-dependent regulation of messenger RNA transcription, processing and translation within biomolecular condensates
Trends in Biochemical Sciences
FUS and TDP-43 Phases in Health and Disease
Biomolecular NMR assignments
NMR assignments for the C-terminal domain of human TDP-43
Jill Bouchard
Contributing editor, Condensates.com
For all of you working on TDP-43 out there, these atomic details might give some insights into its behavior in condensates and pathological aggregates.
bioRxiv
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Trends in biochemical sciences
Microbial Prions: Dawn of a New Era
bioRxiv
Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains
Journal of molecular cell biology
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Immunity
It’s a Phase That EBF1 Is Going Through
Jill Bouchard
Contributing editor, Condensates.com
Here's the Preview article for an Immunity paper about a prion-like domain with a pioneering function in transcription.
BioRxiv
Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrils
Jill Bouchard
Contributing editor, Condensates.com
I find the interplay between TDP-43 and α-Synuclein phase separation very intriguing. How about you?
Frontiers in cellular neuroscience
Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises
bioRxiv
Sequence-encoded and Composition-dependent Protein-RNA Interactions Control Multiphasic Condensate Morphologies
bioRxiv