bioRxiv

Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions

bioRxiv

Phase separation and molecular ordering of the prion-like domain of the thermosensory protein EARLY FLOWERING 3

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases

bioRxiv

Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates

Biophysical chemistry

Shapeshifter TDP-43: Molecular mechanism of structural polymorphism, aggregation, phase separation and their modulators

bioRxiv

Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteins

Nature communications

Metamorphism in TDP-43 prion-like domain determines chaperone recognition

bioRxiv

Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1

Proceedings of the National Academy of Sciences of the United States of America

Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation

Must Read

Cell

Functional partitioning of transcriptional regulators by patterned charge blocks

Science bulletin

Arabidopsis AUTOPHAGY-RELATED3 (ATG3) facilitates the liquid-liquid phase separation of ATG8e to promote autophagy

The Journal of biological chemistry

A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity

Nature communications

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

Molecular neurodegeneration

Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy

Bioscience trends

How do RNA binding proteins trigger liquid-liquid phase separation in human health and diseases?

Communications biology

Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS

bioRxiv

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

bioRxiv

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domain

The Journal of biological chemistry

Intrinsically disordered plant protein PARCL co-localizes with RNA in phase-separated condensates whose formation can be regulated by mutating the PLD

BioEssays : news and reviews in molecular, cellular and developmental biology

Prion-like

Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions

Phase separation and molecular ordering of the prion-like domain of the thermosensory protein EARLY FLOWERING 3

Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases

Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates

Shapeshifter TDP-43: Molecular mechanism of structural polymorphism, aggregation, phase separation and their modulators

Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteins

Metamorphism in TDP-43 prion-like domain determines chaperone recognition

Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1

Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation

Functional partitioning of transcriptional regulators by patterned charge blocks

Arabidopsis AUTOPHAGY-RELATED3 (ATG3) facilitates the liquid-liquid phase separation of ATG8e to promote autophagy

A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy

How do RNA binding proteins trigger liquid-liquid phase separation in human health and diseases?

Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domain

Intrinsically disordered plant protein PARCL co-localizes with RNA in phase-separated condensates whose formation can be regulated by mutating the PLD

Importin α/β and the tug of war to keep TDP-43 in solution: quo vadis?

Intern – Computational biology (m/f/d)

Scientist/Sr. Scientist – In Vitro Pharmacology (IVP)

Associate Director – Medicinal Chemistry