Frontiers in plant science
Most Recent
Cell death and differentiation
Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective
Jill Bouchard
Contributing editor, Condensates.com
Of course this review covers some new evidence that phase separation plays a role in this process.
Immunity
A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin
bioRxiv
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Frontiers in aging neuroscience
Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases
Jill Bouchard
Contributing editor, Condensates.com
This review covers the evidence that molecular chaperones are recruited to certain condensates to help preserve the correct material properties for proper function.
Biomolecules
Intrinsically Disordered Proteins: Insights from Poincaré, Waddington, and Lamarck
Jill Bouchard
Contributing editor, Condensates.com
This review covers recent work showing how IDPs with prion-like properties drive new traits and adaptive opportunities in cells via phase separation.
Viruses
Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates
Molecular cell
A Prion-based Thermosensor in Plants
Jill Bouchard
Contributing editor, Condensates.com
Here's a commentary about a Nature article from earlier this year on the phase separation of a thermosensor in plants.
Nucleic acids research
RNA as the stone guest of protein aggregation
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review discussing the role of RNA in the phase separations (liquid and solid) related to the prion-like aggregation that leads to disease.
Experimental & molecular medicine
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
Jill Bouchard
Contributing editor, Condensates.com
This review briefly mentions how phase separation plays a role in TDP-43's prion-like propagation.
Developmental cell
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force
PLoS computational biology
Protein-protein interactions in neurodegenerative diseases: A conspiracy theory
Jill Bouchard
Contributing editor, Condensates.com
Even if you're also tired of seeing political conspiracy theories these days, this is a phase-separation-based-conspiracy theory that is worth thinking about.
Biochimica et biophysica acta Molecular cell research
A prion-like domain of Tpk2 catalytic subunit of protein kinase A modulates P-body formation in response to stress in budding yeast
Molecular biology and evolution
Natural selection on the phase-separation properties of FUS during 160 million years of mammalian evolution
Frontiers in bioengineering and biotechnology
Potential of Microfluidics and Lab-on-Chip Platforms to Improve Understanding of ” prion-like” Protein Assembly and Behavior
Jill Bouchard
Contributing editor, Condensates.com
Developments in microfluidic methods seem to have exploded this year. This review might spark some ideas for studying aggregation-prone condensates.
International journal of molecular sciences
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA
Molecular biology of the cell
The prion-like domain of FUS is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions
Briefings in bioinformatics
Proteome-scale analysis of phase-separated proteins in immunofluorescence images
bioRxiv
Sequence-encoded and Composition-dependent Protein-RNA Interactions Control Multiphasic Condensate Topologies
Nature
A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis
Jill Bouchard
Contributing editor, Condensates.com
Unsurprisingly, this thermosensor functions via temperature-mediated phase separation. ;)