Here’s a handy new database for all things phase separation. I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/biapss/

Prion-like

Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domain

Intrinsically disordered plant protein PARCL co-localizes with RNA in phase-separated condensates whose formation can be regulated by mutating the PLD

Importin α/β and the tug of war to keep TDP-43 in solution: quo vadis?

p53 amyloid aggregation in cancer: function, mechanism, and therapy

ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures

Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates

Molecular determinants of Karyopherin-β2 chaperone and disaggregation activity

Uncovering the molecular mechanism for dual effect of ATP on phase separation in FUS solution

Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors

Developing Bonded Potentials for a Coarse-Grained Model of Intrinsically Disordered Proteins

Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separation

Regulation of TIA-1 Condensates: Zn 2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation

A Census of Human Methionine-Rich Prion-like Domain-Containing Proteins

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

Understanding and evolving prions by yeast multiplexed assays

Aging can transform single-component protein condensates into multiphase architectures

VIDEO: Bede Portz on An Introduction to Biomolecular Condensates in Disease and to Dewpoint Therapeutics

The physics of liquid-to-solid transitions in multi-domain protein condensates

BIAPSS: A Comprehensive Physicochemical Analyzer of Proteins Undergoing Liquid-Liquid Phase Separation

Jill Bouchard

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Head of Translational (Preclinical) Pharmacology – Neurobiology

Head of Translational (Preclinical) Pharmacology – Oncology