Nature microbiology
Most Recent
Trends in biochemical sciences
Biomolecular Condensates in the Nucleus
Jill Bouchard
Contributing editor, Condensates.com
Need an update on what's new with nuclear condensates? This will be a good place to start!
Molecular neurodegeneration
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
Jill Bouchard
Contributing editor, Condensates.com
This study shows an important consideration for condensate studies: does the tag affect the solubility of the protein of interest?
International journal of biological macromolecules
Copper and Iron Ions Accelerate the Prion-Like Propagation of α-synuclein: A Vicious Cycle in Parkinson’s Disease
Jill Bouchard
Contributing editor, Condensates.com
Here's another reminder that ions matter in phase separation!
Non-coding RNA
LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
Jill Bouchard
Contributing editor, Condensates.com
This review discusses evidence that phase separation plays a role in the assembly of paraspeckles.
mSystems
SynBio and the Boundaries Between Functional and Pathogenic RepA-WH1 Bacterial Amyloids
Jill Bouchard
Contributing editor, Condensates.com
What can we learn from functional amyloids about how to harness the power of condensates? Perhaps this synthetic biology perspective will give us some insights.
Neural regeneration research
Prion-like Domain Disease-Causing Mutations and Misregulation of Alternative Splicing Relevance in Limb-Girdle Muscular Dystrophy (LGMD) 1G
Jill Bouchard
Contributing editor, Condensates.com
This perspective discusses the effect disease mutations have on LLPS and subsequent aggregation.
Prion
Prion Domains as a Driving Force for the Assembly of Functional Nanomaterials
Scientific reports
Identification of the Novel Polymorphisms and Potential Genetic Features of the Prion Protein Gene (PRNP) in Horses, a Prion Disease-Resistant Animal
Jill Bouchard
Contributing editor, Condensates.com
This study uses various bioinformatic analyses to look at the single nucleotide polymorphisms (SNPs) that contribute to making horses prion-resistant animals. This might provide some insights on how to think about and study amyloid propensity for phase-separating proteins.
International journal of molecular sciences
Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 With MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting article discussing the relationship between miRNA and the mislocalization of proteins associated with neurodegeneration.
bioRxiv
Phe-Gly Motifs Drive Fibrillization of TDP-43’s Prion-Like Domain Droplets
Jill Bouchard
Contributing editor, Condensates.com
I find it very interesting that the outer edges of droplets nucleated fibrils.
PeerJ
Deep Conservation of Prion-Like Composition in the Eukaryotic Prion-Former Pub1/Tia1 Family and Its Relatives
Jill Bouchard
Contributing editor, Condensates.com
Understanding the evolution of stress granule hub proteins could help us piece together links to aberrant phase separation, and aggregation.
Jun
18
IDPSeminars: Tanja Mittag & Perdita Barran — June 18
Thursday, June 18, 2020
Kitchen Table Talk
Tatjana Trcek on Germ Granule mRNA Self-Assembly
mBio
Intercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells
Jill Bouchard
Contributing editor, Condensates.com
Intriguing... a bacterial prion-like protein can pass aggregates onto daughter cells, and cause similar effects on mitrochondria as neurodegeneration. Then the authors took it a couple steps further and put it into mammals--read on for all the details.
Chemical communications (Cambridge, England)
Uncovering the Pathological Functions of Ser404 Phosphorylation by Semisynthesis of a Phosphorylated TDP-43 Prion-Like Domain
Cell stress
Role of RNA Binding Proteins With Prion-Like Domains in Muscle and Neuromuscular Diseases
Biomolecules
The Status of p53 Oligomeric and Aggregation States in Cancer
Jill Bouchard
Contributing editor, Condensates.com
This review covers all the ways p53 is involved in cancers... from condensates to filaments.
BioRxiv
Translational inhibition and phase separation primes the epigenetic silencing of transposons
Jill Bouchard
Contributing editor, Condensates.com
I hadn't heard of siRNA bodies, but it looks like they've been around for a couple of years now. Check this article out to get the latest info on them.
Nature
LRP1 Is a Master Regulator of Tau Uptake and Spread
Jill Bouchard
Contributing editor, Condensates.com
Here's some stellar work showing that LRP1 interacts w/ lysine residues in Tau, allowing Tau to spread to other neurons.