Essays in biochemistry
Most Recent
Trends in cell biology
Targeting of biomolecular condensates to the autophagy pathway
Biomolecules
The Role of Intrinsically Disordered Proteins in Liquid-Liquid Phase Separation during Calcium Carbonate Biomineralization
Cancers
The Long and the Short of It: NEAT1 and Cancer Cell Metabolism
Nature communications
Protein condensation diseases: therapeutic opportunities
Biochimica et biophysica acta Molecular cell research
Sequestration of cellular native factors by biomolecular assemblies: Physiological or pathological?
Biology
Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors
Frontiers in molecular biosciences
Micellization: A new principle in the formation of biomolecular condensates
Frontiers in oncology
Phase separation in epigenetics and cancer stem cells
Frontiers in plant science
Nuclear dynamics: Formation of bodies and trafficking in plant nuclei
Frontiers in genetics
LncRNAs divide and rule: The master regulators of phase separation
Frontiers in plant science
Recent advances in the chromatin-based mechanism of FLOWERING LOCUS C repression through autonomous pathway genes
Trends in Pharmacological Sciences
Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
Mariano Oppikofer
Project Lead, Pfizer, Inc.
By taking a deep dive into the field of RNA therapeutics, our article complements the great review published by our Dewpoint colleagues in Nature Reviews Drug Discovery entitled "Modulating biomolecular condensates: a novel approach to drug discovery". We provide readers with forward-looking insights into a drug discovery era that integrates the evolving fields of biomolecular condensates and RNA therapeutics to deliver novel opportunities for patients.
Cells
Proteostasis Deregulation in Neurodegeneration and Its Link with Stress Granules: Focus on the Scaffold and Ribosomal Protein RACK1
International journal of biological macromolecules
Aberrant liquid-liquid phase separation and amyloid aggregation of proteins related to neurodegenerative diseases
Cancers
Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer
Jill Bouchard
Editor in Chief, Condensates.com
This review has a nice section on the structure of paraspeckles.
Frontiers in immunology
When liquid-liquid phase separation meets viral infections
Current opinion in chemical biology
Shedding light on current trends in molecular optogenetics
Jill Bouchard
Editor in Chief, Condensates.com
If you'd like to know more about this increasingly popular LLPS method, this should be a good review to start with.
Journal of cellular physiology
Tau liquid-liquid phase separation: At the crossroads of tau physiology and tauopathy
Essays in biochemistry
Controlling amyloid formation of intrinsically disordered proteins and peptides: slowing down or speeding up?
Jill Bouchard
Editor in Chief, Condensates.com
Given that many of these amyloid-forming IDPs are attracted to condensates, this could be a good review to read if you want to gain insights into how to drug them.