Oct
18
Protein phase transitions in ageing and age-related diseases: from atomic resolution to cellular solutions
Monday, October 18, 2021 | Roscoff, France
Most Recent
International journal of molecular sciences
Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation
Jill Bouchard
Managing editor, Condensates.com
Here's a new optogenetics method to use for a stress granule protein; I hope it can be useful for others too.
International journal of molecular sciences
RNA-Binding Proteins and the Complex Pathophysiology of ALS
Jill Bouchard
Managing editor, Condensates.com
Here's a nice review about the role of mutations in RNA-binding proteins that causes dysfunction of various membraneless organelles.
Kitchen Table Talk
Must ReadVIDEO: Shana Elbaum-Garfinkle on Emergent Material Properties of Biomolecular Condensates
Antiviral research
Proteomic Analysis Identifies the RNA Helicase DDX3X as a Host Target Against SARS-CoV-2 Infection
Jill Bouchard
Managing editor, Condensates.com
Here's some interesting new data reporting on the role of stress granules in SARS-CoV-2 infection.
Neurobiology of disease
Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes
Osteoarthritis and cartilage
TDP-43 maintains chondrocyte homeostasis and alleviates cartilage degradation in osteoarthritis
Jill Bouchard
Managing editor, Condensates.com
This paper implicates stress granules in arthritis via TDP-43 regulation.
bioRxiv
Rice MEL2 regulates the timing of meiotic transition as a component of cytoplasmic RNA granules
Jill Bouchard
Managing editor, Condensates.com
Here's a conserved plant protein that seems to be important for regulating both P bodies and stress granules. I wonder if it's a scaffold or a client?
Journal of virology
Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation
Jill Bouchard
Managing editor, Condensates.com
Cool--these compounds shut down a virus by triggering stress granule formation in only infected cells.
Science advances
LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation
BioEssays : news and reviews in molecular, cellular and developmental biology
Paraspeckle nuclear condensates: Global sensors of cell stress?
Jill Bouchard
Managing editor, Condensates.com
This review covers the role phase separation plays in how paraspeckles help cells respond to stress.
EMBO reports
Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling
Infectious disorders drug targets
An Overview of Immune Evasion Strategies of DNA and RNA Viruses
Jill Bouchard
Managing editor, Condensates.com
It's not surprising to see that stress granules are one of the main topics covered in this review about how viruses evade their hosts.
Journal of neuroscience research
Synaptic dysfunction in amyotrophic lateral sclerosis/frontotemporal dementia: Therapeutic strategies and novel biomarkers
The FEBS journal
Stress granules: Regulators or by-products?
Jill Bouchard
Managing editor, Condensates.com
If you're interested in the role of stress granules in immune responses, this could be an interesting read.
Frontiers in cell and developmental biology
Dr. Jekyll and Mr. Hyde? Physiology and Pathology of Neuronal Stress Granules
eLife
Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation
Cell reports
High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes
Life science alliance
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system
Jill Bouchard
Managing editor, Condensates.com
What happens to once sequestered proteins when stress granules dissolve? This paper looks into the role of ubiquitin-mediated degradation.
The FEBS journal