Neural regeneration research
Most Recent
Emerging topics in life sciences
Granule Regulation by Phase Separation During Drosophila Oogenesis
Acta neuropathologica
SFPQ and Tau: Critical Factors Contributing to Rapid Progression of Alzheimer’s Disease
Jill Bouchard
Contributing editor, Condensates.com
This work covers how 2 important players in stress granules contribute to aberrant SG dynamics and ultimately pathology. I like the use of both in vitro and in vivo studies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
A Proposed Role for the SARS-CoV-2 Nucleocapsid Protein in the Formation and Regulation of Biomolecular Condensates
Frontiers in molecular neuroscience
Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke
Jill Bouchard
Contributing editor, Condensates.com
This is a real next-level in vivo study on how methylation and stress granule formation play a role in strokes, culminating in opening new opportunities for treatment.
bioRxiv
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
Journal of medical virology
Subversion of Host Stress Granules by Coronaviruses: Potential Roles of π-rich Disordered Domains of Viral Nucleocapsids
Emerging topics in life sciences
The Multiscale and Multiphase Organization of the Transcriptome
Jill Bouchard
Contributing editor, Condensates.com
Not every condensate is liquid: This review covers all the different phases used to organize the transcriptome.
Development (Cambridge, England)
mRNA Localization Is Linked to Translation Regulation in the Caenorhabditis elegans Germ Lineage
Jill Bouchard
Contributing editor, Condensates.com
Why are mRNA directed to germ granules? Read further to find out.
The FEBS journal
Novel FMRP Interaction Networks Linked to Cellular Stress
Jill Bouchard
Contributing editor, Condensates.com
It looks like this protein interacts with many other proteins in condensates. I wonder if that means this one shuttles between various condensates?
The Journal of cell biology
Coupling of Translation Quality Control and mRNA Targeting to Stress Granules
Molecular neurodegeneration
Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review integrating all the recent advancements in neurodegeneration studies (including how condensates play a role).
Molecular reproduction and development
Whole-body Heat Exposure Causes Developmental Stage-Specific Apoptosis of Male Germ Cells
Jill Bouchard
Contributing editor, Condensates.com
Heat stress affecting stress granules can impact human cells too--consider the testis.
Autophagy
Puncta Intended: Connecting the Dots Between Autophagy and Cell Stress Networks
Jill Bouchard
Contributing editor, Condensates.com
It looks like the fourth Vancouver Autophagy Symposium covered how new methods are being applied to understanding how stress granules and amyloids are connected to autophagy.
Journal of cell science
Proteomic Analysis Reveals the Direct Recruitment of Intrinsically Disordered Regions to Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
Here's a careful analysis of what proteins make up yeast stress granules to figure out why they form a less dynamic compartment than SGs in animals. Go figure, IDPs seem to play a major role.
Cellular and molecular life sciences : CMLS
Stress Granule Subtypes: An Emerging Link to Neurodegeneration
Molecular cell
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
And these interactions link the nuclear and cytoplasmic stress responses. I would think this axis could become therapeutically relevant some day.
Cold Spring Harbor symposia on quantitative biology
RNP Granule Formation: Lessons From P-Bodies and Stress Granules
Nature plants
DHH1/DDX6-like RNA Helicases Maintain Ephemeral Half-Lives of Stress-Response mRNAs
Microbial Cell Factories
Coiled-coil Inspired Functional Inclusion Bodies
Jill Bouchard
Contributing editor, Condensates.com
It looks like not all inclusion bodies are bad--if biotechnology can harness their power and mitigate their weaknesses. And here's one idea of how to do that.