Molecular cell
Most Recent
Frontiers in plant science
Identification and Characterization of the Heat-Induced Plastidial Stress Granules Reveal New Insight Into Arabidopsis Stress Response
Tiny liquid droplets are driving a cell biology rethink
Cell death & disease
Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells
Nature medicine
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
Methods in molecular biology (Clifton, NJ)
Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
These authors had a pretty stellar Nat Chem Biol paper showing how acetylation regulates phase separation last year. Now they're sharing their protocol--check it out!
The EMBO journal
SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs
Nanoscale
Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network
Jill Bouchard
Contributing editor, Condensates.com
This could be a really useful method for anyone wanting to screen drugs that may modulate stress granules.
RNA (New York, NY)
RNA partitioning into stress granules is based on the summation of multiple interactions
Jill Bouchard
Contributing editor, Condensates.com
Here's a biochemical breakdown of the protein/RNA interactions underlying the formation of stress granules. I wonder if one can glean some key insights about how these interactions also affect phase separation in general?
Scientific reports
Vimentin protects differentiating stem cells from stress
Jill Bouchard
Contributing editor, Condensates.com
This protein plays an important role in differentiation and stress tolerance in neurons, and it looks like there's some interesting condensate behavior at the heart of it.
BioEssays : news and reviews in molecular, cellular and developmental biology
Cytoplasmic mRNPs revisited: Singletons and condensates
Jill Bouchard
Contributing editor, Condensates.com
Here's a review detailing the composition, size, shape, and function of several RNP granules.
Frontiers in aging neuroscience
Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases
Jill Bouchard
Contributing editor, Condensates.com
This review covers the evidence that molecular chaperones are recruited to certain condensates to help preserve the correct material properties for proper function.
Briefings in bioinformatics
MloDisDB: a manually curated database of the relations between membraneless organelles and diseases
Jill Bouchard
Contributing editor, Condensates.com
Do you want to know what disease(s) your favorite protein or condensate is associated with? You can use this online platform to find out.I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/mlodisdb/
Frontiers in immunology
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction
iScience
A Nuclear Stress Pathway that Parallels Cytoplasmic Stress Granule Formation
Jill Bouchard
Contributing editor, Condensates.com
Interesting--Here's a paper about an alternative stress pathway involving condensates that includes nuclear stress foci (nucSF) instead of stress granules.
Archives of medical research
Role of Chikungunya nsP3 in Regulating G3BP1 Activity, Stress Granule Formation and Drug Efficacy
Jill Bouchard
Contributing editor, Condensates.com
This article draws some interesting connections between the effects of viruses and cancer on stress granule to figure out how to combat drug resistance in cancer drugs.
PhD position in evaluation of liquid-liquid phase separation in disease cells and in vitro using fluorescence lifetime imaging and image correlation spectroscopy
The University of Manchester | Manchester, United Kingdom
ApplyFrontiers in neurology
Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins
Jill Bouchard
Contributing editor, Condensates.com
It's interesting how different types of tau aggregates have different propensities for localizing to stress granules.
bioRxiv
SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs
Science translational medicine
ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics
Jill Bouchard
Contributing editor, Condensates.com
This is quite a research study spanning all the way from patients to biophysical phase separation analysis. Check it out!