Molecular & cellular oncology
Most Recent
bioRxiv
High fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate
Viruses
Dance with the Devil: Stress Granules and Signaling in Antiviral Responses
American journal of cancer research
Understanding the roles of stress granule during chemotherapy for patients with malignant tumors
Jill Bouchard
Contributing editor, Condensates.com
This review delves into what one needs to know in order to target stress granules to treat cancer.
Journal of cell science
Mammalian stress granules and P bodies at a glance
Jill Bouchard
Contributing editor, Condensates.com
This review does a nice job of describing the similarities and differences between stress granules and P bodies... obviously one of their commonalities is LLPS ;)
Molecular biology of the cell
The prion-like domain of FUS is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions
Plants (Basel, Switzerland)
Dynamics and Functions of Stress Granules and Processing Bodies in Plants
Jill Bouchard
Contributing editor, Condensates.com
Take a look at how the field of phase separation has shaped what we know about condensates in plants!
Cancers
Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?
Jill Bouchard
Contributing editor, Condensates.com
With so many of these proteins being involved in condensate formation, I'm sure one strategy for therapeutic intervention will to affect phase separation.
Biochimica et biophysica acta Molecular basis of disease
Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model
Jill Bouchard
Contributing editor, Condensates.com
ICYMI, hypusine is an uncommon PTM on lysine, which causes interesting interactions between this translation initiation factor and proteins involved in 2 condensates (both stress granules and the nuclear pore complex).
Nucleic acids research
RNA-binding and prion domains: the Yin and Yang of phase separation
Molecular cell
Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change
Neurobiology of disease
Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons
Progress in molecular biology and translational science
The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation
Veterinary microbiology
Critical role for G3BP1 in infectious bursal disease virus (IBDV)-induced stress granule formation and viral replication
Jill Bouchard
Contributing editor, Condensates.com
This clever virus exploits G3BP1's phase separation to harness stress granules for its replication.
Pharmacological research
Targeting stress granules: A novel therapeutic strategy for human diseases
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review discussing how stress granules are involved in various diseases and may be targeted therapeutically.
Neurobiology of disease
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress
Jill Bouchard
Contributing editor, Condensates.com
These authors compared the interactomes of disease vs normal neurons to find out why stress granule formation is affected.
bioRxiv
Oxidized RNA Bodies compartmentalize translation quality control in Saccharomyces cerevisiae
Jill Bouchard
Contributing editor, Condensates.com
ORBs (oxidized RNA bodies) look to be a new membraneless organelle that communicate with stress granules and P bodies.
Reviews of physiology, biochemistry and pharmacology
Stress Granules in Cancer
Jill Bouchard
Contributing editor, Condensates.com
This review discusses how the discovery that stress granules form by LLPS has contributed to our current understanding of the role they play in tumorigenesis.
Molecular cell
An In Vitro Assembly System Identifies Roles for RNA Nucleation and ATP in Yeast Stress Granule Formation
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice method to help in the effort to understand the role of RNA in stress granule formation.
bioRxiv