Nature communications
Most Recent
Cell
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
Apr
23
IDPfun webinars: Zsuzsanna Dosztanyi & Nicolás Palopoli — April 23
Friday, April 23, 2021
Molecular cell
p53 mediates target gene association with nuclear speckles for amplified RNA expression
Aging
Nuclear envelope tethering inhibits the formation of ALT-associated PML bodies in ALT cells
Jill Bouchard
Managing editor, Condensates.com
I always find the interaction between condensates and membranes fascinating. This paper identifies some important players when it comes to ALT-associated PML bodies.
Current opinion in chemical biology
Intrinsically disordered proteins and biomolecular condensates as drug targets
International journal of molecular sciences
The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development
Jill Bouchard
Managing editor, Condensates.com
I like that these authors analyzed both intrinsic disorder and LLPS propensity of proteins with disease mutations. Check out their results!
Biomolecules
Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies
Jill Bouchard
Managing editor, Condensates.com
These authors identified IDPs that drive cancers, and it looks like many of them are involved in condensates.
bioRxiv
Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression
Trends in cell biology
Phase Separation in Genome Organization across Evolution
Frontiers in chemistry
Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins
Jill Bouchard
Managing editor, Condensates.com
Are you out of ideas for how to probe the fuzzy interactions of a condensate-loving IDP? Maybe this review (and mass spec) can help.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Protein phase separation and its role in chromatin organization and diseases
BioEssays : news and reviews in molecular, cellular and developmental biology
Paraspeckle nuclear condensates: Global sensors of cell stress?
Jill Bouchard
Managing editor, Condensates.com
This review covers the role phase separation plays in how paraspeckles help cells respond to stress.
Current protocols
Isolating and Analyzing Protein Containing Granules from Cells
Jill Bouchard
Managing editor, Condensates.com
Check this out--Separating full condensates from cells could be super helpful for a lot of in vitro experiments out there.
bioRxiv
Single-stranded nucleic acid sensing and coacervation by linker histone H1
Cell death & disease
Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2
Jill Bouchard
Managing editor, Condensates.com
Here's a paper that implicates a nuclear speckle splicing factor in cancer malignancy.
bioRxiv
Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Nature cell biology
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis
Faculty reviews
Recent advances in understanding tight junctions
Jill Bouchard
Managing editor, Condensates.com
This review covers the recent evidence supporting the role of phase separation in the formation of tight junctions.
Molecular Cell
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress