Cancers
Most Recent
bioRxiv
SLX4 assembles nuclear condensates that compartmentalize the SUMO-RNF4 pathway and drive DNA repair
Sep
20
Cold Spring Harbor Laboratory meeting on Epigenetics & Chromatin (2022)
Tuesday, September 20, 2022 | Cold Spring Harbor, NY, United States
Angewandte Chemie (International ed in English)
Mechanistic Insights into the Phase Separation Behavior and Pathway-Directed Information Exchange in all-DNA Droplets
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Emerging Implications of Phase Separation in Cancer
Oncogene
A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC
International journal of biological macromolecules
Phase separation of p53 induced by its unstructured basic region and prevented by oncogenic mutations in tetramerization domain
Haematologica
Activation of lncRNA NEAT1 leads to survival advantage of multiple myeloma cells by supporting a positive regulatory loop with DNA repair proteins
Jill Bouchard
Editor in Chief, Condensates.com
The authors speculate that their results suggest paraspeckles may be a good therapeutic target for Multiple Myeloma.
bioRxiv
Phase separation of Myc differentially regulates gene transcription
Oncogene
CPEB3 suppresses gastric cancer progression by inhibiting ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies
Frontiers in oncology
Phase separation in epigenetics and cancer stem cells
Nature communications
Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Journal of hematology & oncology
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
Frontiers in genetics
LncRNAs divide and rule: The master regulators of phase separation
Cell reports
Scaffolding viral protein NC nucleates phase separation of the HIV-1 biomolecular condensate
bioRxiv
APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus
Cancers
Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer
Jill Bouchard
Editor in Chief, Condensates.com
This review has a nice section on the structure of paraspeckles.
bioRxiv
Androgen receptor condensates as drug targets
Nature reviews Drug discovery
Modulating biomolecular condensates: a novel approach to drug discovery
Cell death & disease