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BioEssays : news and reviews in molecular, cellular and developmental biology
Paraspeckle nuclear condensates: Global sensors of cell stress?
Jill Bouchard
Managing editor, Condensates.com
This review covers the role phase separation plays in how paraspeckles help cells respond to stress.
Current protocols
Isolating and Analyzing Protein Containing Granules from Cells
Jill Bouchard
Managing editor, Condensates.com
Check this out--Separating full condensates from cells could be super helpful for a lot of in vitro experiments out there.
bioRxiv
Single-stranded nucleic acid sensing and coacervation by linker histone H1
Cell death & disease
Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2
Jill Bouchard
Managing editor, Condensates.com
Here's a paper that implicates a nuclear speckle splicing factor in cancer malignancy.
bioRxiv
Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Nature cell biology
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis
Faculty reviews
Recent advances in understanding tight junctions
Jill Bouchard
Managing editor, Condensates.com
This review covers the recent evidence supporting the role of phase separation in the formation of tight junctions.
Molecular Cell
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
The Journal of cell biology
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation
Nature communications
Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription
Cellular and molecular gastroenterology and hepatology
Paraspeckle promotes hepatocellular carcinoma immune escape by sequestering IFNGR1 mRNA
Proceedings of the National Academy of Sciences of the United States of America
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
Jill Bouchard
Managing editor, Condensates.com
This should be an interesting read: condensates with "unique properties" seed amyloids.
Kitchen Table Talk
Must ReadVIDEO: Huaiying Zhang on Liquid-Liquid Phase Separation in Telomere Maintenance of ALT Cancer
Frontiers in cell and developmental biology
Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner
Jill Bouchard
Managing editor, Condensates.com
This paper reveals a new connection between P bodies and cancer via the sequestration of LIN28A mRNA.
Apr
14
2021 RNA Biology Symposium
Wednesday, April 14, 2021
bioRxiv
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation
Nucleic acids research
Tandem RNA binding sites induce self-association of the stress granule marker protein TIA-1
The EMBO journal
Self-assembly of multi-component mitochondrial nucleoids via phase separation
Computational and structural biotechnology journal
Structure-based peptide design targeting intrinsically disordered proteins: Novel histone H4 and H2A peptidic inhibitors
Jill Bouchard
Managing editor, Condensates.com
Are you also surprised a structure-based method can successfully find inhibitors for IDPs? Maybe these ideas will help in the effort to drug IDPs in condensates.