Nucleic Acids Research
Mechanism of efficient double-strand break repair by a long non-coding RNA
Jill Bouchard
Contributing editor, Condensates.com
What doesn't phase separation do?! These authors show it has a role in repairing lncRNA too.
Most Recent
Biochemical pharmacology
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly
Current protocols in bioinformatics
Exploring Manually Curated Annotations of Intrinsically Disordered Proteins with DisProt
Jill Bouchard
Contributing editor, Condensates.com
I bet that being able to explore manually curated annotations will really help answer complex questions about IDPs.
Proceedings of the National Academy of Sciences of the United States of America
Phase separation by ssDNA binding protein controlled via protein-protein and protein-DNA interactions
Biochimica et biophysica acta Gene regulatory mechanisms
From start to end: phase separation and transcriptional regulation
Annals of clinical and translational neurology
Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration
Jill Bouchard
Contributing editor, Condensates.com
This article identifies that nuclear speckles may play a key role in this type cancer. I hope it leads to a condensate-based therapeutic!
Oct
13
Yale School of Medicine–Biomolecular condensates in gene regulation, cancer and medicine
Tuesday, October 13, 2020
Biochimica et biophysica acta Molecular cell research
Molecular mechanisms of stress granule assembly and disassembly
International journal of molecular sciences
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA
British journal of cancer
G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer
Jill Bouchard
Contributing editor, Condensates.com
Here's an article about how G3BP1 helps stress granules play self defense in cancer cells.
Cell
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
Cell reports
Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
Jill Bouchard
Contributing editor, Condensates.com
It looks like nuclear speckles play a pretty big role in HIV viral infection.
Molecular neurobiology
Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases
Jill Bouchard
Contributing editor, Condensates.com
Phase separation gets a quick shout out in this review--for being part of how hnRNP proteins may regulate stress granule formation and be involved in ALS.
PhD position (Ageing & Disease, Bioinformatics & Computational Biology): Elucidation of the molecular mechanisms regulating protein homeostasis by liquid-liquid phase separation
Institute of Molecular Biology (IMB) | Mainz, Germany
ApplyWorld journal of gastroenterology
Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications
Postdoctoral Research Associate in Cell Biology/Biophysics of Biomolecular Condensates
St. Jude Children's Research Hospital | Memphis, TN USA
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Targeting the intrinsically disordered architectural High Mobility Group A (HMGA) oncoproteins in breast cancer: learning from the past to design future strategies
Jill Bouchard
Contributing editor, Condensates.com
This review covers how condensates could be exploited to treat breast cancer. Check it out if you're looking for inspiration.
bioRxiv
Capillary forces drive pioneer transcription factor-mediated DNA condensation
Molecular & cellular oncology
Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Jill Bouchard
Contributing editor, Condensates.com
Here's a comment on a previous paper the authors published, which they speculate may involve phase separation--I bet they have a long list of experiments planned to test this.
Postdoc positions at University of California – San Francisco
UCSF | San Francisco, CA
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