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Nature cell biology
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis
Biomolecules
Protein-Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting analysis of disease mutations in IDPs, and likely has implications for condensate misbehavior.
Developmental cell
Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates
Cell death & disease
Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies
Jill Bouchard
Contributing editor, Condensates.com
Interesting--an lncRNA "hijacks both the chimeric mRNAs and fusion proteins in nuclear speckles." Looks like paraspeckles aren't the only speckle condensate with close ties to lncRNA.
International journal of molecular sciences
p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles
Jill Bouchard
Contributing editor, Condensates.com
If you also hadn't heard much about p62, the phase separating protein that acts as a hub for many signalling pathways, then this review should catch you up.
Jill Bouchard
Contributing editor, Condensates.com
If you also had't heard much about p62, the phase separating protein that acts as a hub for many signaling pathways, then this review should catch you up.
bioRxiv
Self-assembly of multi-component mitochondrial nucleoids via phase separation
Human molecular genetics
Lysine acetylation regulates the RNA binding, subcellular localization and inclusion formation of FUS
Jill Bouchard
Contributing editor, Condensates.com
Another case where PTMs, acetylation in particular, affect disease pathology.
Kitchen Table Talk
Christine Mayr on Condensate Networks
Molecular cell
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
Jill Bouchard
Contributing editor, Condensates.com
Cool. Stress tolerance can be achieved by inhibiting stress granule formation and opens up new ideas to help with male fertility!
Nature communications
HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
Jill Bouchard
Contributing editor, Condensates.com
It looks like HIV hits nuclear speckles hard in order to get into the host genome.
European biophysics journal : EBJ
Fast and synchronized fluctuations of cortical actin negatively correlate with nucleoli liquid-liquid phase separation in T cells
Transient droplets organize biochemical reactions inside cells
Nature reviews Molecular cell biology
RNA Contributions to the Form and Function of Biomolecular Condensates
Jill Bouchard
Contributing editor, Condensates.com
This review covers some of the principles Amy touched upon when she visited us for her Kitchen Table Talk on RNA-driven phase separation.
Non-coding RNA
LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
Jill Bouchard
Contributing editor, Condensates.com
This review discusses evidence that phase separation plays a role in the assembly of paraspeckles.
Biomaterials
Spatiotemporally Tracking of Nano-Biofilaments Inside the Nuclear Pore Complex Core
Cancer science
Nuclear Microenvironment in Cancer: Control Through Liquid-Liquid Phase Separation
The Journal of cell biology
Liquid-liquid Phase Separation in Autophagy
Molecular Biology of the Cell
Nuclear Body Phase Separation Drives Telomere Clustering in ALT Cancer Cells
bioRxiv
Transcriptomic and proteomic regulation through abundant, dynamic, and independent arginine methylation by Type I and Type II PRMTs
Jill Bouchard
Contributing editor, Condensates.com
Here's a new method to look at Arg methylation, and the authors demonstrated an enrichment of it in LLPS.