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BioRxiv
Amyloid fibril-based hydrogels for high-throughput tumor spheroid modeling
bioRxiv
PARprolink: a photoaffinity probe for identifying poly(ADP-ribose)-binding proteins
Jill Bouchard
Contributing editor, Condensates.com
Not only did these authors develop a new method to identify PAR-binding proteins, they also found them to be enriched in condensates. Read further to find out which ones.
Cell
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations
STAR protocols
Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation
Postdoctoral Research Fellow 4D Nucleome Full-time
Johns Hopkins University | Baltimore, MD, USA
ApplyJournal of neurochemistry
The multi-functional RNA binding protein G3BP1 and its potential implication in neurodegenerative disease
Jill Bouchard
Contributing editor, Condensates.com
This review covers G3BP1's role in phase separation and the formation of stress granules in looking for clues for how to target it therapeutically.
bioRxiv
Poly(ADP-ribose) potentiates ZAP antiviral activity
Jill Bouchard
Contributing editor, Condensates.com
It looks like the ZAP protein has previously been shown to go to stress granules during viral infections and this work suggests it may be triggered by PAR binding.
Cell biology international
Regulation of processing bodies: From viruses to cancer epigenetic machinery
Immunity
It’s a Phase That EBF1 Is Going Through
Jill Bouchard
Contributing editor, Condensates.com
Here's the Preview article for an Immunity paper about a prion-like domain with a pioneering function in transcription.
Trends in biochemical sciences
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions
Jill Bouchard
Contributing editor, Condensates.com
This review covers the role of G-quads in phase separation.
PLoS Biology
Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses
Jill Bouchard
Contributing editor, Condensates.com
The authors also discuss how their results implicate regulation of the phase behavior (ie. material properties) of the nucleolus. I'm sure they're already working on finding out if that's true.
FACULTY POSITION IN MOLECULAR THERAPEUTICS
Fox Chase Cancer Center | Philadelphia, PA, USA
ApplyFaze Medicines Launches With $81 Million Series A Financing to Leverage New Biology of Biomolecular Condensates to Treat Disease
BioEssays : news and reviews in molecular, cellular and developmental biology
RNA-protein interactions: Central players in coordination of regulatory networks
Developmental cell
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
Nucleic acids research
MobiDB: intrinsically disordered proteins in 2021
Jill Bouchard
Contributing editor, Condensates.com
Cool! This IDP database includes annotations about LLPS!I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/mobidb/
Nature reviews Genetics
RNA-binding proteins in human genetic disease
bioRxiv
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
Dec
14
VIB Online Course on Liquid-Liquid Phase Separation
Monday, December 14, 2020