Kitchen Table Talk
Most Recent
Molecular biology of the cell
Matrix Stiffness-Sensitive Long-Non Coding RNA NEAT1 Seeded Paraspeckles in Cancer Cells
Jill Bouchard
Contributing editor, Condensates.com
This is a very neat study about the mechanical properties of paraspeckles in cancer cells! (I meant the 'neat' part before I remembered they were studying NEAT1 btw ;) )
Kitchen Table Talk
Tatjana Trcek on Germ Granule mRNA Self-Assembly
BioRxiv
A role for the autophagic receptor, SQSTM1/p62, in trafficking NF-ÎșB/RelA to nucleolar aggresomes
Jill Bouchard
Contributing editor, Condensates.com
Cool! This paper looks into what regulates the sequestration of certain proteins to the nucleolus so it can be exploited to treat cancer.
Journal of hepatology
C19orf66 Is an Interferon-Induced Inhibitor of HCV Replication That Restricts Formation of the Viral Replication Organelle
Jill Bouchard
Contributing editor, Condensates.com
This study finds "a stress granule protein-dominated interactome of C19orf66" in liver cells infected with hepatitis C, which helps cells reduce viral replication.
Biomolecules
The Status of p53 Oligomeric and Aggregation States in Cancer
Jill Bouchard
Contributing editor, Condensates.com
This review covers all the ways p53 is involved in cancers... from condensates to filaments.
Vaccines
Crosstalk Between Stress Granules, Exosomes, Tumour Antigens, and Immune Cells: Significance for Cancer Immunity
Jill Bouchard
Contributing editor, Condensates.com
This review discusses ides for targeting stress granules for anti-cancer therapeutics.
bioRxiv
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
Biochimica et biophysica acta Molecular cell research
The Promyelocytic Leukemia Protein Isoform PML1 Is an Oncoprotein and a Direct Target of the Antioxidant Sulforaphane (SFN)
Jill Bouchard
Contributing editor, Condensates.com
Here's some work showing the involvement of PML in the inhibition of breast cancer.
PLoS pathogens
Chemical Intervention of Influenza Virus mRNA Nuclear Export
Jill Bouchard
Contributing editor, Condensates.com
I wonder if trapping these viral mRNA inside nuclear speckles would be a therapeutic option?
Tanaffos
New Insights Into Connection of Nucleolar Functions and Cancer
Genes & development
Telomere Length Heterogeneity in ALT Cells Is Maintained by PML-dependent Localization of the BTR Complex to Telomeres
Jill Bouchard
Contributing editor, Condensates.com
Solid work showing the difference in PML bodies between healthy and cancerous cells. I hope these insights open up new avenues for therapeutic intervention!
The Journal of cell biology
Multivalent Weak Interactions Between Assembly Units Drive Synaptonemal Complex Formation
Nature cell biology
Phase Separation of TAZ Compartmentalizes the Transcription Machinery to Promote Gene Expression
Nature structural & molecular biology
Roles of the BRD4 Short Isoform in Phase Separation and Active Gene Transcription
Journal of Biomedical Science
Functions and Properties of Nuclear lncRNAs-from Systematically Mapping the Interactomes of lncRNAs
Jill Bouchard
Contributing editor, Condensates.com
This review has a nice summary of all the condensates lncRNAs are involved in.
Biophysical reviews
Biological Phase Separation: Cell Biology Meets Biophysics
Journal of cell science
SNAP29 Mediates the Assembly of Histidine-Induced CTP Synthase Filaments in Proximity to the Cytokeratin Network
Aging cell
The Involvement of Stress Granules in Aging and Aging-Associated Diseases
Journal of molecular biology