Dec
14
VIB Online Course on Liquid-Liquid Phase Separation
Monday, December 14, 2020
Most Recent
Frontiers in oncology
Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells
Tiny liquid droplets are driving a cell biology rethink
Cell death & disease
Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells
Methods in molecular biology (Clifton, NJ)
Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
These authors had a pretty stellar Nat Chem Biol paper showing how acetylation regulates phase separation last year. Now they're sharing their protocol--check it out!
Nanoscale
Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network
Jill Bouchard
Contributing editor, Condensates.com
This could be a really useful method for anyone wanting to screen drugs that may modulate stress granules.
bioRxiv
Biomolecular Condensation Drives Leukemia Caused by NUP98-Fusion Proteins
Nature genetics
MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome
bioRxiv
Human coronaviruses disassemble processing bodies
Cell biochemistry and function
Novel nucleolar localization of clusterin and its associated functions in human oral cancers: An in vitro and in silico analysis
Jill Bouchard
Contributing editor, Condensates.com
This paper is about some complex communication between nucleoli and cajal bodies in cancer cells. Check it out to find out more.
eLife
Protein phase separation and its role in tumorigenesis
The FEBS Journal
Alternative systems for misfolded protein clearance: life beyond the proteasome
Jill Bouchard
Contributing editor, Condensates.com
This review discusses the role of phase separation in accumulating misfolded proteins into the various membraneless organelles that are part of a cell's proteostasis network.
Briefings in bioinformatics
MloDisDB: a manually curated database of the relations between membraneless organelles and diseases
Jill Bouchard
Contributing editor, Condensates.com
Do you want to know what disease(s) your favorite protein or condensate is associated with? You can use this online platform to find out. I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/mlodisdb/
Non-coding RNA
NEAT1 and Paraspeckles in Cancer Development and Chemoresistance
iScience
A Nuclear Stress Pathway that Parallels Cytoplasmic Stress Granule Formation
Jill Bouchard
Contributing editor, Condensates.com
Interesting--Here's a paper about an alternative stress pathway involving condensates that includes nuclear stress foci (nucSF) instead of stress granules.
Archives of medical research
Role of Chikungunya nsP3 in Regulating G3BP1 Activity, Stress Granule Formation and Drug Efficacy
Jill Bouchard
Contributing editor, Condensates.com
This article draws some interesting connections between the effects of viruses and cancer on stress granule to figure out how to combat drug resistance in cancer drugs.
Department of Physiology Faculty Positions
University of Pennsylvania - Perelman School of Medicine | Philadelphia, PA, USA
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Baylor College of Medicine | Houston, Texas, USA
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