Autophagy
The BECN1 N-terminal domain is intrinsically disordered
Jill Bouchard
Editor in Chief, Condensates.com
Sometimes just purifying the protein is tricky. Perhaps this article provides some tips!
Most Recent
bioRxiv
A role for liquid-liquid phase separation in ESCRT-mediated nuclear envelope reformation
Jill Bouchard
Editor in Chief, Condensates.com
Cool! A molecular "O-ring" has been identified! A membrane protein coordinates condensation around microtubules to disassemble the spindle & reform the nuclear envelope after mitosis.
Frontiers in chemistry
Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation
Jill Bouchard
Editor in Chief, Condensates.com
This is quite an interesting idea for therapeutic intervention.
Nucleic acids research
The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis
Jill Bouchard
Editor in Chief, Condensates.com
An interesting link between cancer and neurodegeneration. Take a look!
Brain sciences
Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies
Jill Bouchard
Editor in Chief, Condensates.com
Interesting... I never expected to see a protein involved in breast cancer show up in neurodegeneration aggregates. BRCA1 is probably trying to help and unable, but I wonder if mutations are involved?
Nature communications
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
Jill Bouchard
Editor in Chief, Condensates.com
This opens up the possibility of targeting condensates to treat colorectal cancer.
Journal of cellular physiology
EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells
Jill Bouchard
Editor in Chief, Condensates.com
The affects on NEAT1 must have also have an impact on paraspeckles.
Cell
Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
Cell
A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3’UTR-Mediated Protein-Protein Interactions
Jill Bouchard
Editor in Chief, Condensates.com
Cool! A new condensate: the TIS granule, named after the protein that drives its formation.
Proceedings of the National Academy of Sciences of the United States of America
Evolution of weak cooperative interactions for biological specificity
Molecular Cell
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
Jill Bouchard
Editor in Chief, Condensates.com
This is my claim to the biomolecular condensates field. I hope you enjoy! If you don't have time for the whole paper, you can check out the 1-minute video abstract the St. Jude communications team helped me make. I've saved it to our library of Resources: https://condensates.com/resources/video-abstract-why-do-some-cells-misbehave/
Science (New York, NY)
Coactivator condensation at super-enhancers links phase separation and gene control
Nature
Phase separation drives heterochromatin domain formation
Cell
A Phase Separation Model for Transcriptional Control
Nature
Decoding ALS: from genes to mechanism
Chemical reviews
Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling
eLife
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
Frontiers in molecular biosciences
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators
Non-coding RNA research
Nuclear Paraspeckles Function in Mediating Gene Regulatory and Apoptotic Pathways
Developmental cell