Apr
27
VIRTUAL: 2021 ASBMB Annual Meeting
Tuesday, April 27, 2021
Most Recent
Nature communications
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein
May
17
VIRTUAL: EMBL conference on Chromatin and Epigenetics
Monday, May 17, 2021
BioRxiv
Design of anti-SARS-CoV-2 molecules from hydroxychloroquine (HCQ) for better binding SARS-CoV-2 N protein
Jill Bouchard
Managing editor, Condensates.com
Interesting: it looks like HCQ inhibits the nucleic-acid induced LLPS of the N protein, and the authors are looking for collaborators to drive this drug design further.
Materials (Basel, Switzerland)
Emerging Silk Material Trends: Repurposing, Phase Separation and Solution-Based Designs
bioRxiv
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
Nature communications
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Antiviral research
Proteomic Analysis Identifies the RNA Helicase DDX3X as a Host Target Against SARS-CoV-2 Infection
Jill Bouchard
Managing editor, Condensates.com
Here's some interesting new data reporting on the role of stress granules in SARS-CoV-2 infection.
Journal of molecular cell biology
Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2
bioRxiv
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
Jill Bouchard
Managing editor, Condensates.com
Nice–designing peptide inhibitors that target the zipper driving phase separation may be an option for therapeutic intervention.
Biomolecular NMR assignments
1 H, 13 C and 15 N Backbone chemical shift assignments of the n-terminal and central intrinsically disordered domains of SARS-CoV-2 nucleoprotein
Jill Bouchard
Managing editor, Condensates.com
This biophysical data likely gives insights into why this protein phase separates.
Pacific Symposium on Biocomputing Pacific Symposium on Biocomputing
SARS-CoV-2 Drug Discovery based on Intrinsically Disordered Regions
Jill Bouchard
Managing editor, Condensates.com
I wonder if any of the IDRs identified go into viral condensates?
Virulence
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses
Jill Bouchard
Managing editor, Condensates.com
This review has a nice summary of how stress granules can have either antiviral or proviral effects during infection.
PLoS pathogens
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
Jill Bouchard
Managing editor, Condensates.com
It looks like coronaviruses have a conserved function of shutting down host stress granules in order to replicate effectively.
Feb
19
IDPfun webinars: Peter Tompa & Tadeo Saldaño — Feb 19
Friday, February 19, 2021
Journal of virology
Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8 mediated G3BP1 Cleavage and Subverts Stress Granules to Promote Viral Replication
bioRxiv
Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids
bioRxiv
The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
Nature communications
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
Cell discovery