COVID-19

bioRxiv

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

• COVID-19
• Infectious Disease
• Methods
• Phase Separation
• Physics of Condensates

Jill Bouchard

Contributing editor, Condensates.com

The authors looked into whether the arrangement of LLPS-promoting and solubilizing sequences in the genome lead to single genome packaging. Read on to learn about generalizable principles of virus compaction.

bioRxiv

The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins

• COVID-19
• Phase Separation

Jill Bouchard

Contributing editor, Condensates.com

I like that the authors discuss what their results mean in the context of all the recent reports that the N protein phase separates.

bioRxiv

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

• COVID-19
• Methods
• Phase Separation
• Physics of Condensates

Molecular cell

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

• COVID-19
• Phase Separation
• Physics of Condensates

Nature communications

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

• COVID-19
• Phase Separation
• Transcription

Molecular cell

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

• COVID-19
• Phase Separation
• Physics of Condensates

Tiny liquid droplets are driving a cell biology rethink

• Cancer
• COVID-19
• Infectious Disease
• Neurodegeneration
• Phase Separation
• Physics of Condensates

The EMBO journal

SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs

• COVID-19
• Infectious Disease
• Neurodegeneration
• Phase Separation
• Physics of Condensates

bioRxiv

Human coronaviruses disassemble processing bodies

• Cancer
• COVID-19
• Infectious Disease

bioRxiv

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs

• COVID-19
• Infectious Disease
• Neurodegeneration
• Transcription

Nucleic acids research

Structural analysis of SARS-CoV-2 genome and predictions of the human interactome

• COVID-19
• Infectious Disease
• Physics of Condensates
• Transcription

BioRxiv

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

• COVID-19
• Phase Separation
• Physics of Condensates

bioRxiv

SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

• COVID-19
• Methods
• Phase Separation
• Physics of Condensates