Nature communications
Most Recent
Annals of the New York Academy of Sciences
Noncoding RNAs: biology and applications-a Keystone Symposia report
Jill Bouchard
Editor in Chief, Condensates.com
Check out the latest and greatest condensate biology presented in the Keystone eSymposium "Noncoding RNAs: Biology and Applications" here.
FEBS letters
SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets
The Journal of biological chemistry
Proximity-dependent biotinylation detects associations between SARS coronavirus nonstructural protein 1 and stress granule-associated proteins
Jill Bouchard
Editor in Chief, Condensates.com
It looks like the SARS coronaviruses are similar to many other viruses in that they also hijack condensates. Take a look at this paper to find out the details.
Science
Nuclear pores dilate and constrict in cellulo
Chemical communications (Cambridge, England)
Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2
Protein science : a publication of the Protein Society
CTD of SARS-CoV-2 N protein is a cryptic domain for binding ATP and nucleic acid that interplay in modulating phase separation
Jan
11
POSTPONED: EMBO Workshop: From molecules to organisms: An integrative view of cell biology
Tuesday, January 11, 2022 | Goldegg, Austria
bioRxiv
Human coronaviruses disassemble processing bodies
PLoS biology
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
International journal of biological macromolecules
Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation
Saudi journal of biological sciences
In Silico Identification of MicroRNAs targeting the Key nucleator of Stress Granules, G3BP: Promising Therapeutics for SARS-CoV‑2 Infection
Cell Discovery
Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein
International journal of biological macromolecules
The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties
Jill Bouchard
Editor in Chief, Condensates.com
These scientists found a significant difference in the phase separation properties of SARS-CoV-2 N protein in the presence and absence of RNA.
Genes & development
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity
Jill Bouchard
Editor in Chief, Condensates.com
It looks like Cajal bodies play an important role in snRNA modification.
bioRxiv
Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA
Nature reviews Microbiology
Targeting viral liquid-liquid phase separation
Jill Bouchard
Editor in Chief, Condensates.com
Here's an In Brief article on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Nature reviews Molecular cell biology
Targeting viruses in their phase
Jill Bouchard
Editor in Chief, Condensates.com
Here's the Research Highlight on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Nature cell biology
Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Biophysical journal
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
Jill Bouchard
Editor in Chief, Condensates.com
This paper explores computationally how LLPS-promoting parts of a genome need to be positioned in order to promote genome packaging.