Jan
11
POSTPONED: EMBO Workshop: From molecules to organisms: An integrative view of cell biology
Tuesday, January 11, 2022 | Goldegg, Austria
Most Recent
bioRxiv
Human coronaviruses disassemble processing bodies
PLoS biology
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
International journal of biological macromolecules
Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation
Saudi journal of biological sciences
In Silico Identification of MicroRNAs targeting the Key nucleator of Stress Granules, G3BP: Promising Therapeutics for SARS-CoV‑2 Infection
Cell Discovery
Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein
International journal of biological macromolecules
The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties
Jill Bouchard
Editor in Chief, Condensates.com
These scientists found a significant difference in the phase separation properties of SARS-CoV-2 N protein in the presence and absence of RNA.
Genes & development
Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity
Jill Bouchard
Editor in Chief, Condensates.com
It looks like Cajal bodies play an important role in snRNA modification.
bioRxiv
Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA
Nature reviews Microbiology
Targeting viral liquid-liquid phase separation
Jill Bouchard
Editor in Chief, Condensates.com
Here's an In Brief article on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Nature reviews Molecular cell biology
Targeting viruses in their phase
Jill Bouchard
Editor in Chief, Condensates.com
Here's the Research Highlight on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Nature cell biology
Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Biophysical journal
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
Jill Bouchard
Editor in Chief, Condensates.com
This paper explores computationally how LLPS-promoting parts of a genome need to be positioned in order to promote genome packaging.
Sep
09
IDPSIG/IDPSeminars Virtual Poster Session
Thursday, September 9, 2021
bioRxiv
Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures
iScience
Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain
Molecular biology
mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts
Jill Bouchard
Editor in Chief, Condensates.com
Here's a very interesting review that discusses how condensates contribute to the translation of mRNA outside of the ER.
Biology
Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility
Jill Bouchard
Editor in Chief, Condensates.com
Here's a nice review about the flexibility of SARS-CoV-2 N protein. Of course it mentions what that means for phase separation. ;)
Cell discovery
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication
The Journal of biological chemistry