Kitchen Table Talk
Must ReadMost Recent
Elife
Mesoscale phase separation of chromatin in the nucleus
ACS chemical neuroscience
C1 Inhibits Liquid-Liquid Phase Separation and Oligomerization of Tau and Protects Neuroblastoma Cells against Toxic Tau Oligomers
bioRxiv
Polarized Dishevelled dissolution and condensation drives embryonic axis specification in oocytes
May
24
Cold Spring Harbor perspectives in biology
Transcription Factor Dynamics
Jill Bouchard
Managing editor, Condensates.com
I bet a lot of what is discussed in this review will also apply to transcriptional condensates.
May
20
INC ACADEMY Webinar: Jekaterina Erenpreisa & Haitham Shaban — May 20
Thursday, May 20, 2021
Nucleic acids research
Single-molecule imaging of epigenetic complexes in living cells: insights from studies on Polycomb group proteins
Jill Bouchard
Managing editor, Condensates.com
Spoiler alert, those insights are related to condensates. ;)
Kitchen Table Talk
Must ReadVIDEO: Carlos CastaƱeda on Ubiquitin-Mediated Phase Transitions in Protein Quality Control
Accounts of chemical research
Biochemical Activity Architectures Visualized-Using Genetically Encoded Fluorescent Biosensors to Map the Spatial Boundaries of Signaling Compartments
The Journal of clinical investigation
Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
Jill Bouchard
Managing editor, Condensates.com
Are stress granules a feature of Huntington's disease neuropathology? These authors try to find out by looking at miRNA compositions in the brain fluid of patients.
Nature neuroscience
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
Developmental cell
LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force
PLoS computational biology
Supercoiled DNA and non-equilibrium formation of protein complexes: A quantitative model of the nucleoprotein ParBS partition complex
Jill Bouchard
Managing editor, Condensates.com
Read this work to learn how to simulate "condensates with unconventional 'leaky' boundaries."
Journal of visualized experiments : JoVE
Chemical Dimerization-Induced Protein Condensates on Telomeres
Chemical communications (Cambridge, England)
Capturing protein droplets: label-free visualization and detection of protein liquid-liquid phase separation with an aggregation-induced emission fluorogen
Apr
27
VIRTUAL: 2021 ASBMB Annual Meeting
Tuesday, April 27, 2021
Molecular Cell
Is transcriptional regulation just going through a phase?
Nature communications
Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4
Jill Bouchard
Managing editor, Condensates.com
These "fuzzy" interactions seem to be suggesting that condensation is involved here. I'm glad the authors discussed this possibility at the end of the paper.
The journal of physical chemistry letters
High-Speed Atomic Force Microscopy Reveals Spatiotemporal Dynamics of Histone Protein H2A Involution by DNA Inchworming
Jill Bouchard
Managing editor, Condensates.com
The authors of this work also reported using this method to monitor reversible LLPS.