Multiple positions in the Lab for Synthetic Macromolecular Assemblies
George Lu Lab @ Rice University | Houston, TX
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Target ID/Interactome Mapping-Group Leader PhD
Dewpoint Therapeutics | Boston, MA USA
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Dewpoint Therapeutics | Boston, MA USA
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Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells
Jill Bouchard
Contributing editor, Condensates.com
It looks like dengue viral capsid phase separates and joins the nucleolus as part of it's invasion strategy... another way (of the many) that viruses use our condensates against us.
Protein & cell
Live Cell Imaging and Proteomic Profiling of Endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated Knock-In
Jill Bouchard
Contributing editor, Condensates.com
Cool. Here's a new method to track endogenous lncRNA in cells and identify proteins it may interact with, whereby they identified new proteins in paraspeckles.
Nature chemical biology
M 6 A-binding YTHDF Proteins Promote Stress Granule Formation
Jill Bouchard
Contributing editor, Condensates.com
ICYMI m6A is methylated mRNA (on the N6 of the adenine), so post-transcriptional modifications play a role in condensate formation just as much as post-translational ones.
Nature Methods
Cell Biology Befriends Soft Matter Physics
bioRxiv
Suppression of liquid-liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells
Jill Bouchard
Contributing editor, Condensates.com
This study suggests LLPS fine-tunes 3D genome organization.
3 funded PhD positions on the Role of phase separation mechanisms in higher-order chromatin organization during development
Université de Montpellier | Montpellier, France
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Cingulin unfolds ZO-1 and organizes myosin-2B and gamma-actin to mechanoregulate apical and tight junction membranes
BioRxiv
Chromatin folding variability across single-cells results from state degeneracy in phase-separation
Nature methods
Pooled CRISPR Screens With Imaging on Microraft Arrays Reveals Stress Granule-Regulatory Factors
Jill Bouchard
Contributing editor, Condensates.com
CRISPR + machine learning + stress granules = really cool stuff!
Cells
Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome
Jill Bouchard
Contributing editor, Condensates.com
Who knew that lipids made it into nuclear condensates?!
Kitchen Table Talk
Amy Gladfelter on RNA-Driven Phase Separation
Scientific Reports
Super-resolution in Situ Analysis of Active Ribosomal DNA Chromatin Organization in the Nucleolus
Jill Bouchard
Contributing editor, Condensates.com
The architecture of nucleoli is fascinating, and we'll get so many more insights into how they work as more awesome methods like this come out.
Kitchen Table Talk
Liam Holt on Crowding and Compression
Screening / Automation Research Associate, Drug Discovery
Dewpoint Therapeutics | Boston, MA, USA
ApplyBrain : a journal of neurology
In Vivo Stress Granule Misprocessing Evidenced in a FUS Knock-In ALS Mouse Model
BMC biology
Nucleus Size and DNA Accessibility Are Linked to the Regulation of Paraspeckle Formation in Cellular Differentiation
Jill Bouchard
Contributing editor, Condensates.com
It looks like nuclear lncRNA condensates (including paraspeckles) might serve important roles in cellular regulation and may be targeted therapeutically.
bioRxiv
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
Jill Bouchard
Contributing editor, Condensates.com
This work takes a deeper look at a newer condensate called DynAPs.