Jun
02
Emily Sontag on Sorting out the JUNQ: the Spatial Nature of Protein Quality Control
Wednesday, June 2, 2021
Most Recent
Apr
06
Online Conference on Phase Separated Systems in the Nucleus
Tuesday, April 6, 2021
Molecular Biology of the Cell
Super resolution light microscopy of the Drosophila Histone Locus Body reveals a core-shell organization associated with expression of replication dependent histone genes
International journal of molecular sciences
Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation
Jill Bouchard
Managing editor, Condensates.com
Here's a new optogenetics method to use for a stress granule protein; I hope it can be useful for others too.
bioRxiv
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Jill Bouchard
Managing editor, Condensates.com
Not only is this a really cool method at the intersection of proteomics and imaging, the database if full of amazing pictures!
bioRxiv
A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency
Caltech professor Ibrahim Cissé applies physics to decode and understand RNA transcription
bioRxiv
Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration
bioRxiv
Single-stranded nucleic acid sensing and coacervation by linker histone H1
BioRxiv
The interplay of chromatin phase separation and lamina interactions in nuclear organization
Faculty reviews
Recent advances in understanding tight junctions
Jill Bouchard
Managing editor, Condensates.com
This review covers the recent evidence supporting the role of phase separation in the formation of tight junctions.
The Journal of cell biology
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation
Molecular Biology of the Cell
Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription
Jill Bouchard
Managing editor, Condensates.com
It looks like nucleoli are intertwined in cell cycle regulation in ways we are just beginning to understand.
Cell reports
High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes
eLife
Single molecule microscopy reveals key physical features of repair foci in living cells
Kitchen Table Talk
Must ReadVIDEO: Huaiying Zhang on Liquid-Liquid Phase Separation in Telomere Maintenance of ALT Cancer
bioRxiv
The nanoscale organization of the Wnt signaling integrator Dishevelled in the development-essential vegetal cortex domain of an egg and early embryo
Jill Bouchard
Managing editor, Condensates.com
The authors discuss the possibility that these puncta are in fact condensates. I bet we can stay tuned for more experiments on that front.
Genes to cells : devoted to molecular & cellular mechanisms
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells
Developmental cell
N 6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles
Jill Bouchard
Managing editor, Condensates.com
It looks like this lncRNA could be an important scaffold for nuclear speckles. Check out the paper for all the details.
bioRxiv