Nature Communications
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Biomaterials
Spatiotemporally Tracking of Nano-Biofilaments Inside the Nuclear Pore Complex Core
Proceedings of the National Academy of Sciences of the United States of America
Enzymatic Degradation of Liquid Droplets of DNA Is Modulated Near the Phase Boundary
Postdoctoral Fellow in RNA Microscopy Lab – Trcek Lab
Johns Hopkins University | Baltimore, MD
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Johns Hopkins Bloomberg School of Public Health | Baltimore, MD
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The emergence of phase separation as an organizing principle in bacteria
eLife
A Quantitative Inventory of Yeast P Body Proteins Reveals Principles of Composition and Specificity
Science (New York, NY)
Disordered Proteins Follow Diverse Transition Paths as They Fold and Bind to a Partner
Jill Bouchard
Contributing editor, Condensates.com
I'd be excited to see if this method can be applied to IDPs inside condensates to understand whats going on in there.
Postdoc in Protein dynamics & NMR spectroscopy – MULDER lab
Aarhus University | Denmark - The happiest country on earth
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Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice
Jill Bouchard
Contributing editor, Condensates.com
It looks like the main problem is the localization of FUS at the synapse and the RNA it brings with it. I wonder if phase separation is at play here?
The Journal of cell biology
Coupling of Translation Quality Control and mRNA Targeting to Stress Granules
Molecular cell
Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation
Jill Bouchard
Contributing editor, Condensates.com
It looks like a lot of important telomere biochemistry happens in and around Cajal bodies.
BMC biology
Unraveling the Molecular Interactions Involved in Phase Separation of Glucocorticoid Receptor
Multiple positions in the Lab for Synthetic Macromolecular Assemblies
George Lu Lab @ Rice University | Houston, TX
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Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation
Jill Bouchard
Contributing editor, Condensates.com
Obviously, LLPS is one of the recent developments that is reshaping our understanding of gene regulation. ;)
Scientific reports
Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells
Jill Bouchard
Contributing editor, Condensates.com
It looks like dengue viral capsid phase separates and joins the nucleolus as part of it's invasion strategy... another way (of the many) that viruses use our condensates against us.
BioRxiv
A localization screen reveals translation factories and widespread co-translational RNA targeting
Protein & cell
Live Cell Imaging and Proteomic Profiling of Endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated Knock-In
Jill Bouchard
Contributing editor, Condensates.com
Cool. Here's a new method to track endogenous lncRNA in cells and identify proteins it may interact with, whereby they identified new proteins in paraspeckles.
Nature chemical biology
M 6 A-binding YTHDF Proteins Promote Stress Granule Formation
Jill Bouchard
Contributing editor, Condensates.com
ICYMI m6A is methylated mRNA (on the N6 of the adenine), so post-transcriptional modifications play a role in condensate formation just as much as post-translational ones.
Nature Methods