Interesting-- the redox-related phase separation of a cholesterol transporter may lead to the deposits causing macular degeneration. AND(!) therapeutically restoring function just happens to interfere with condensate formation.

Molecular neurodegeneration

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Jill Bouchard

Contributing editor, Condensates.com

This study shows an important consideration for condensate studies: does the tag affect the solubility of the protein of interest?

Proceedings of the National Academy of Sciences of the United States of America

Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation

European biophysics journal : EBJ

Fast and synchronized fluctuations of cortical actin negatively correlate with nucleoli liquid-liquid phase separation in T cells

Biochimica et biophysica acta Molecular cell research

Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock

Jill Bouchard

Contributing editor, Condensates.com

And that clustering is part of a multi-step phase separation process.

Molecular cell

Imaging

Architecture and function of human uromodulin filaments in urinary tract infections

Jill Bouchard

Scaffold-scaffold interactions regulate cell polarity in a bacterium

Jill Bouchard

Genome-Scale Imaging of the 3D Organization and Transcriptional Activity of Chromatin

Jill Bouchard

The Interplay between Phase Separation and Gene-Enhancer Communication: A Theoretical Study

Epigenetic memory as a time integral over prior history of Polycomb phase separation

A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting

Studying Protein Aggregation in the Context of Liquid-liquid Phase Separation Using Fluorescence and Atomic Force Microscopy, Fluorescence and Turbidity Assays, and FRAP

P-bodies are sites of rapid RNA decay during the neural crest epithelial—mesenchymal transition

Jill Bouchard

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Jill Bouchard

Speculating on the Roles of Nuclear Speckles: How RNA-Protein Nuclear Assemblies Affect Gene Expression

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells

Jill Bouchard

Formation and function of bacterial organelles

Jill Bouchard

Phase separation drives decision making in cell division

Christine Mayr on Condensate Networks

Apolipoprotein E isoform-specific phase transitions in the retinal pigment epithelium drive disease phenotypes in age-related macular degeneration

Jill Bouchard

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Jill Bouchard

Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation

Fast and synchronized fluctuations of cortical actin negatively correlate with nucleoli liquid-liquid phase separation in T cells

Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock

Jill Bouchard

Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation

Biochemist, Postdoc

Scientist/Senior Scientist, Discovery Biology

Laboratory Operations Assistant