The FEBS journal
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bioRxiv
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
The journal of physical chemistry B
A Data-Driven Hydrophobicity Scale for Predicting Liquid-Liquid Phase Separation of Proteins
Proceedings of the National Academy of Sciences of the United States of America
Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease
Jill Bouchard
Managing editor, Condensates.com
Here's a report of a helicase that looks to be important for stress granule formation and immunity to mycobacteria.
Nature communications
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein
Nature cell biology
The STING phase-separator suppresses innate immune signalling
Nature Cell Biology
STING condensates on ER limit IFN response
Jill Bouchard
Managing editor, Condensates.com
Here's the News & Views article associated with the recent Nature Cell Biol paper about the STING phase-separator.
Apr
15
IDPSeminars: Kausik Si & Elisar Barbar — April 15
Thursday, April 15, 2021
Antibiotics (Basel, Switzerland)
FtsZ Interactions and Biomolecular Condensates as Potential Targets for New Antibiotics
Cells
Metal Ions Induce Liquid Condensate Formation by the F Domain of Aedes aegypti Ecdysteroid Receptor
bioRxiv
SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
Antiviral research
Proteomic Analysis Identifies the RNA Helicase DDX3X as a Host Target Against SARS-CoV-2 Infection
Jill Bouchard
Managing editor, Condensates.com
Here's some interesting new data reporting on the role of stress granules in SARS-CoV-2 infection.
Journal of molecular cell biology
Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2
Journal of virology
Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation
Jill Bouchard
Managing editor, Condensates.com
Cool--these compounds shut down a virus by triggering stress granule formation in only infected cells.
bioRxiv
Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus
BioEssays : news and reviews in molecular, cellular and developmental biology
Paraspeckle nuclear condensates: Global sensors of cell stress?
Jill Bouchard
Managing editor, Condensates.com
This review covers the role phase separation plays in how paraspeckles help cells respond to stress.
The EMBO journal
Histone chaperone CAF-1 promotes HIV-1 latency by leading the formation of phase-separated suppressive nuclear bodies
Infectious disorders drug targets
An Overview of Immune Evasion Strategies of DNA and RNA Viruses
Jill Bouchard
Managing editor, Condensates.com
It's not surprising to see that stress granules are one of the main topics covered in this review about how viruses evade their hosts.
bioRxiv
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2
Jill Bouchard
Managing editor, Condensates.com
Nice–designing peptide inhibitors that target the zipper driving phase separation may be an option for therapeutic intervention.
The FEBS journal
Stress granules: Regulators or by-products?
Jill Bouchard
Managing editor, Condensates.com
If you're interested in the role of stress granules in immune responses, this could be an interesting read.