Scientist/Senior Scientist, Discovery Biology
Dewpoint Therapeutics | Boston, MA, USA
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bioRxiv
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
Jill Bouchard
Contributing editor, Condensates.com
The authors looked into whether the arrangement of LLPS-promoting and solubilizing sequences in the genome lead to single genome packaging. Read on to learn about generalizable principles of virus compaction.
mSphere
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7
Jill Bouchard
Contributing editor, Condensates.com
The authors implicate stress granules and potentially other cellular compartments in mediating antiviral effects.
Microorganisms
Escherichia coli HS and Enterotoxigenic Escherichia coli Hinder Stress Granule Assembly
Jill Bouchard
Contributing editor, Condensates.com
It looks like both good and bad kinds of strains of E. coli have an interesting relationship with stress granules. Check out the details to learn more.
bioRxiv
Rotavirus Replication Factories Are Complex Ribonucleoprotein Condensates
bioRxiv
Poly(ADP-ribose) potentiates ZAP antiviral activity
Jill Bouchard
Contributing editor, Condensates.com
It looks like the ZAP protein has previously been shown to go to stress granules during viral infections and this work suggests it may be triggered by PAR binding.
Cell biology international
Regulation of processing bodies: From viruses to cancer epigenetic machinery
The EMBO journal
Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages
Jill Bouchard
Contributing editor, Condensates.com
It looks like the condensates in infected macrophages get all messed up. Check out this paper to find out more.
PLoS pathogens
The cucumber mosaic virus 1a protein regulates interactions between the 2b protein and ARGONAUTE 1 while maintaining the silencing suppressor activity of the 2b protein
Jill Bouchard
Contributing editor, Condensates.com
This paper is about a cool way a virus involves P-bodies to hide in stealth mode.
eLife
Viral-induced alternative splicing of host genes promotes influenza replication
Jill Bouchard
Contributing editor, Condensates.com
It looks like nuclear speckles may be a key location for the splicing agents that help this virus with replication.
International journal of molecular sciences
Liquid-Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus-Host Interactions
Life (Basel, Switzerland)
Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview
Jill Bouchard
Contributing editor, Condensates.com
This review talks about the Science paper from this year about how patterning of aromatic residues can drive phase separation in IDPs.
Journal of immunology (Baltimore, Md : 1950)
NUDT21 Links Mitochondrial IPS-1 to RLR-Containing Stress Granules and Activates Host Antiviral Defense
Jill Bouchard
Contributing editor, Condensates.com
Here's a paper about some complicated cross-talk between mitochondria and stress granules during viral infection to get the immune system activated.
Tiny liquid droplets are driving a cell biology rethink
The EMBO journal
SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs
Virology
Cauliflower mosaic virus P6 inclusion body formation: A dynamic and intricate process
Jill Bouchard
Contributing editor, Condensates.com
If it looks like a duck and quacks like a duck, it's probably a... condensate! haha :) Well I really meant if it looks like a blob and fuses...
bioRxiv
Human coronaviruses disassemble processing bodies
Tenure-track Assistant Professor position in Cellular Engineering and Manufacturing
Boston University | Boston, MA, USA
ApplyFrontiers in immunology
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction
Archives of medical research
Role of Chikungunya nsP3 in Regulating G3BP1 Activity, Stress Granule Formation and Drug Efficacy
Jill Bouchard
Contributing editor, Condensates.com
This article draws some interesting connections between the effects of viruses and cancer on stress granule to figure out how to combat drug resistance in cancer drugs.