Journal of virology

EV71 2A Protease inhibits P-body formation to promote viral RNA synthesis

Infectious Disease

Jill Bouchard

Managing editor, Condensates.com

I see a lot of interesting work about the role of stress granules in viral infections. This work looks at P bodies. Check out this paper for a fresh take on condensates in infections.

Nature reviews Molecular cell biology

Targeting viruses in their phase

Jill Bouchard

Managing editor, Condensates.com

Here's the Research Highlight on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV

Journal of molecular cell biology

Multifaceted roles of centrosomes in development, health, and disease

bioRxiv

Condensate-mediated reactivation of mumps virus infection under stress

Must Read

Nature cell biology

Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

PLoS pathogens

The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury

Jill Bouchard

Managing editor, Condensates.com

Here's yet another viral protein (a ds-RBP) that affects stress granules in order to evade the immune response.

Must Read

Nature

A condensate-hardening drug blocks RSV replication in vivo

Jill Bouchard

Managing editor, Condensates.com

so excited about this!! :D

Biophysical journal

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

Jill Bouchard

Managing editor, Condensates.com

This paper explores computationally how LLPS-promoting parts of a genome need to be positioned in order to promote genome packaging.

Hepatology (Baltimore, Md)

SLU7 prevents oxidative stress-mediated HNF4α degradation preserving hepatic differentiation and protecting from liver damage

Jill Bouchard

Managing editor, Condensates.com

Here's a new protein identified to be important for stress granule functions in liver cells.

Cells

New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections

Chemistry (Weinheim an der Bergstrasse, Germany)

Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III

Jill Bouchard

Managing editor, Condensates.com

Ooh, check it out! This antimicrobial peptide stabilizes droplet forms of α-syn, at the expense of fibrils.

Journal of immunology (Baltimore, Md : 1950)

TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly

eLife

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Infectious Disease

Jill Bouchard

Managing editor, Condensates.com

Here's another way viruses target stress granules to evade the immune response.

bioRxiv

Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids

Molecular biology

mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts

Jill Bouchard

Managing editor, Condensates.com

Here's a very interesting review that discusses how condensates contribute to the translation of mRNA outside of the ER.

Biology

Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility

Jill Bouchard

Managing editor, Condensates.com

Here's a nice review about the flexibility of SARS-CoV-2 N protein. Of course it mentions what that means for phase separation. ;)

Cell discovery

The Journal of biological chemistry

Arginine Methylation of SARS-Cov-2 Nucleocapsid Protein Regulates RNA Binding, its Ability to Suppress Stress Granule Formation and Viral Replication

Frontiers in molecular biosciences

Infectious Disease

EV71 2A Protease inhibits P-body formation to promote viral RNA synthesis

Jill Bouchard

Targeting viruses in their phase

Jill Bouchard

Multifaceted roles of centrosomes in development, health, and disease

Condensate-mediated reactivation of mumps virus infection under stress

Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury

Jill Bouchard

A condensate-hardening drug blocks RSV replication in vivo

Jill Bouchard

Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging

Jill Bouchard

SLU7 prevents oxidative stress-mediated HNF4α degradation preserving hepatic differentiation and protecting from liver damage

Jill Bouchard

New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections

Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III

Jill Bouchard

TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

Jill Bouchard

Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids

mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts

Jill Bouchard

Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility

Jill Bouchard

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication

The mechanism underlying the organization of Borna disease virus inclusion bodies is unique among mononegaviruses

Jill Bouchard

Arginine Methylation of SARS-Cov-2 Nucleocapsid Protein Regulates RNA Binding, its Ability to Suppress Stress Granule Formation and Viral Replication

SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates?

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