Most Recent
Scientific reports
Contributing editor, Condensates.com
It looks like dengue viral capsid phase separates and joins the nucleolus as part of it's invasion strategy... another way (of the many) that viruses use our condensates against us.
PLoS pathogens
Contributing editor, Condensates.com
Interesting stuff: These authors show that upon infection of a leukemia-linked retrovirus, important DNA repair enzymes get sequestered away in Tax speckle structures, which leads to further genomic instability in leukemia cells.
Viruses
Contributing editor, Condensates.com
Here's another way viruses affect host stress granules.
Kitchen Table Talk
bioRxiv
Contributing editor, Condensates.com
I love when "regulates" invokes phase separation :)
mBio
Contributing editor, Condensates.com
They forgot to mention "that phase separates" at the end of the title ;)
PLoS pathogens
Contributing editor, Condensates.com
This seems to be a very careful study teasing apart which molecular interactions are at play when PML bodies are disrupted in certain viral infections.
Environmental microbiology
Contributing editor, Condensates.com
I believe this is a preview for a PNAS paper about phage liquid crysatlline droplets that came out earlier this year.
Advances in virus research
Contributing editor, Condensates.com
Interesting, this work finds that the protein involved in viral uncoating also reverses LLPS of RNA-binding proteins. This could be important step in finding antiviral treatments.
Journal of the American Chemical Society
Contributing editor, Condensates.com
This study might give us insight into the kinetics at play inside condensates.
Cell reports
Contributing editor, Condensates.com
Knowing that Zn-related phase separation is a common feature of retroviruses may give us insights into how to make drugs against them.
Journal of virology
Contributing editor, Condensates.com
Here's another case (#2 this week) of stress granules playing a role in host defense to viral infection.
Journal of hepatology
Contributing editor, Condensates.com
This study finds "a stress granule protein-dominated interactome of C19orf66" in liver cells infected with hepatitis C, which helps cells reduce viral replication.
Current opinion in cell biology
Contributing editor, Condensates.com
This review discusses how phase separation plays a role in some signaling cascades.
Science advances
Viruses
Contributing editor, Condensates.com
This review discusses how viruses disrupt stress granules in order to keep on replicating... clever beasts!
PLoS pathogens
Contributing editor, Condensates.com
I wonder if trapping these viral mRNA inside nuclear speckles would be a therapeutic option?
BioRxiv
Contributing editor, Condensates.com
This is quite the Herculean effort in a time of need to find potential drug targets against COVID-19... It's cool that some of the proteins identified belong in stress granules!
Proceedings of the National Academy of Sciences of the United States of America
Contributing editor, Condensates.com
It's interesting that viral infection results in the aggregation of α-synuclein, but not of tau or TDP-43. And the anti-influenza drug prevented said aggregation. I bet there are some pearls of wisdom within.