Kitchen Table Talk
Most Recent
bioRxiv
RNA binding regulates TRIM25-mediated RIG-I ubiquitylation
Jill Bouchard
Contributing editor, Condensates.com
I love when "regulates" invokes phase separation :)
mBio
Conserved Outer Tegument Component UL11 From Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein
Jill Bouchard
Contributing editor, Condensates.com
They forgot to mention "that phase separates" at the end of the title ;)
PLoS pathogens
Revisiting Promyelocytic Leukemia Protein Targeting by Human Cytomegalovirus Immediate-Early Protein 1
Jill Bouchard
Contributing editor, Condensates.com
This seems to be a very careful study teasing apart which molecular interactions are at play when PML bodies are disrupted in certain viral infections.
Environmental microbiology
Protect Thy Host: Pf4 Phages Shield P
Jill Bouchard
Contributing editor, Condensates.com
I believe this is a preview for a PNAS paper about phage liquid crysatlline droplets that came out earlier this year.
Advances in virus research
Influenza A Virus Uncoating
Jill Bouchard
Contributing editor, Condensates.com
Interesting, this work finds that the protein involved in viral uncoating also reverses LLPS of RNA-binding proteins. This could be important step in finding antiviral treatments.
Journal of the American Chemical Society
The Mechanism of Coupled Folding-Upon-Binding of an Intrinsically Disordered Protein
Jill Bouchard
Contributing editor, Condensates.com
This study might give us insight into the kinetics at play inside condensates.
Cell reports
Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking
Jill Bouchard
Contributing editor, Condensates.com
Knowing that Zn-related phase separation is a common feature of retroviruses may give us insights into how to make drugs against them.
Journal of virology
RNase L Amplifies Interferon Signaling by Inducing PKR-mediated Antiviral Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
Here's another case (#2 this week) of stress granules playing a role in host defense to viral infection.
Journal of hepatology
C19orf66 Is an Interferon-Induced Inhibitor of HCV Replication That Restricts Formation of the Viral Replication Organelle
Jill Bouchard
Contributing editor, Condensates.com
This study finds "a stress granule protein-dominated interactome of C19orf66" in liver cells infected with hepatitis C, which helps cells reduce viral replication.
NIH signals more interest in biomolecular condensates
Current opinion in cell biology
Higher-order Assemblies in Innate Immune and Inflammatory Signaling: A General Principle in Cell Biology
Jill Bouchard
Contributing editor, Condensates.com
This review discusses how phase separation plays a role in some signaling cascades.
Science advances
Measles Virus Nucleo- And Phosphoproteins Form Liquid-Like Phase-Separated Compartments That Promote Nucleocapsid Assembly
Viruses
The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
Jill Bouchard
Contributing editor, Condensates.com
This review discusses how viruses disrupt stress granules in order to keep on replicating... clever beasts!
PLoS pathogens
Chemical Intervention of Influenza Virus mRNA Nuclear Export
Jill Bouchard
Contributing editor, Condensates.com
I wonder if trapping these viral mRNA inside nuclear speckles would be a therapeutic option?
BioRxiv
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
Jill Bouchard
Contributing editor, Condensates.com
This is quite the Herculean effort in a time of need to find potential drug targets against COVID-19... It's cool that some of the proteins identified belong in stress granules!
Proceedings of the National Academy of Sciences of the United States of America
Disruption of Cellular Proteostasis by H1N1 Influenza A Virus Causes α-Synuclein Aggregation
Jill Bouchard
Contributing editor, Condensates.com
It's interesting that viral infection results in the aggregation of α-synuclein, but not of tau or TDP-43. And the anti-influenza drug prevented said aggregation. I bet there are some pearls of wisdom within.
Archives of biochemistry and biophysics
Physical Basis of the Disorder-Order Transition
Jill Bouchard
Contributing editor, Condensates.com
Polymer physics has become very useful in describing interactions at play in condensates as well as disordered systems. I imagine the discussion on residue-solvent interactions will be enlightening for condensates too.
Proceedings of the National Academy of Sciences of the United States of America
Phage Liquid Crystalline Droplets Form Occlusive Sheaths That Encapsulate and Protect Infectious Rod-Shaped Bacteria
Jill Bouchard
Contributing editor, Condensates.com
This is crazy: some bacteria can hide inside condensates?! I hope we can use this information to combat antibiotic resistance.