Molekuliarnaia biologiia

[mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts]

Jill Bouchard

Managing editor, Condensates.com

This review discusses all the condensates that may have translation occurring inside,

PLoS pathogens

Deconstructing virus condensation

bioRxiv

The Relative Binding Position of Nck and Grb2 Adaptors Dramatically Impacts Actin-Based Motility of Vaccinia Virus

Jill Bouchard

Managing editor, Condensates.com

In this paper, the authors discuss the implications of phospho-site spatial positioning on phase separation.

bioRxiv

A TIR-1/SARM1 phase transition underlies p38 immune pathway activation in the C. elegans intestine

International journal of biological macromolecules

Borna disease virus phosphoprotein triggers the organization of viral inclusion bodies by liquid-liquid phase separation

The Plant cell

The emerging role of biomolecular condensates in plant immunity

THE EMBO journal

Some viruses need to phase-separate to replicate

Jill Bouchard

Managing editor, Condensates.com

Here's the News & Views article on the recent paper in EMBO J about LLPS in rotaviruses.

bioRxiv

Human metapneumovirus P protein independently drives phase separation and recruits N protein to liquid-like inclusion bodies

Biomolecules

Identification of a Region in the Common Amino-terminal Domain of Hendra Virus P, V, and W Proteins Responsible for Phase Transition and Amyloid Formation

Viruses

Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments

PLoS pathogens

Phase separation of a plant virus movement protein and cellular factors support virus-host interactions

Jill Bouchard

Managing editor, Condensates.com

This paper shows a delicate balance between pro- and anti-viral condensates.

The EMBO journal

Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses

mBio

The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

Jill Bouchard

Managing editor, Condensates.com

This paper shows an interesting interaction between a virus and nuclear speckles.

Saudi journal of biological sciences

In Silico Identification of MicroRNAs targeting the Key nucleator of Stress Granules, G3BP: Promising Therapeutics for SARS-CoV‑2 Infection

Frontiers in Cell and Developmental Biology

A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity

Molecular cell

Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

Viruses

How Do Flaviviruses Hijack Host Cell Functions by Phase Separation?

Journal of cell science

ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms

Infectious Disease

Communications biology

Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

Nucleic Acids Research

Infectious Disease

[mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts]

Jill Bouchard

Deconstructing virus condensation

The Relative Binding Position of Nck and Grb2 Adaptors Dramatically Impacts Actin-Based Motility of Vaccinia Virus

Jill Bouchard

A TIR-1/SARM1 phase transition underlies p38 immune pathway activation in the C. elegans intestine

Borna disease virus phosphoprotein triggers the organization of viral inclusion bodies by liquid-liquid phase separation

The emerging role of biomolecular condensates in plant immunity

Some viruses need to phase-separate to replicate

Jill Bouchard

Human metapneumovirus P protein independently drives phase separation and recruits N protein to liquid-like inclusion bodies

Identification of a Region in the Common Amino-terminal Domain of Hendra Virus P, V, and W Proteins Responsible for Phase Transition and Amyloid Formation

Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments

Phase separation of a plant virus movement protein and cellular factors support virus-host interactions

Jill Bouchard

Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses

The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus

Jill Bouchard

In Silico Identification of MicroRNAs targeting the Key nucleator of Stress Granules, G3BP: Promising Therapeutics for SARS-CoV‑2 Infection

A Tale of Usurpation and Subversion: SUMO-Dependent Integrity of Promyelocytic Leukemia Nuclear Bodies at the Crossroad of Infection and Immunity

Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

How Do Flaviviruses Hijack Host Cell Functions by Phase Separation?

ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms

Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS

Sr. Research Associate – Cell Engineering

Scientist/Sr. Scientist – Platform Technology

Principal Scientist – In Vitro Pharmacology (IVP)