Infectious Disease

Archives of medical research

Role of Chikungunya nsP3 in Regulating G3BP1 Activity, Stress Granule Formation and Drug Efficacy

• Cancer
• Infectious Disease
• Neurodegeneration

Jill Bouchard

Contributing editor, Condensates.com

This article draws some interesting connections between the effects of viruses and cancer on stress granule to figure out how to combat drug resistance in cancer drugs.

Biomaterials Science

Thermostabilization of viruses via complex coacervation

• Infectious Disease
• Phase Separation
• Physics of Condensates

bioRxiv

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAs

• COVID-19
• Infectious Disease
• Neurodegeneration
• Transcription

The Journal of biological chemistry

Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: novel antiviral activity against VSV

• Infectious Disease
• Phase Separation

Jill Bouchard

Contributing editor, Condensates.com

Check out how these proteins help resist viruses using phase separation!

Viruses

Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates

• Infectious Disease
• Neurodegeneration
• Phase Separation
• Physics of Condensates

Accounts of Chemical Research

Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles

• Cancer
• Infectious Disease

Jill Bouchard

Contributing editor, Condensates.com

This review talks about how the field of condensates is intersecting with another hot field: immunotherapy.

eLife

A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body

• Infectious Disease

Nucleic acids research

Structural analysis of SARS-CoV-2 genome and predictions of the human interactome

• COVID-19
• Infectious Disease
• Physics of Condensates
• Transcription

Biochemical pharmacology

Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly

• Cancer
• Infectious Disease
• Metabolism
• Neurodegeneration

Cellular and molecular life sciences : CMLS

IDPology of the living cell: intrinsic disorder in the subcellular compartments of the human cell

• Infectious Disease
• Methods

PLoS pathogens

Defining the proteolytic landscape during enterovirus infection

• Infectious Disease

Jill Bouchard

Contributing editor, Condensates.com

I wonder how many other condensate proteins get cleaved by this virus? Check out their full catalog to find out more.

Nucleic acids research

Periphilin self-association underpins epigenetic silencing by the HUSH complex

• Infectious Disease
• Methods
• Phase Separation
• Transcription

Jill Bouchard

Contributing editor, Condensates.com

All the common features of phase separation (intrinsic disorder, dimerization, and Arg/Tyr low complexity) contribute to fibril and condensate formation here.

mBio

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

• Infectious Disease
• Phase Separation
• Physics of Condensates

Jill Bouchard

Contributing editor, Condensates.com

Here's a nice article showing RSV inclusion bodies are membraneless organelles formed by LLPS.

Viruses

Functional Characterization of Pepper Vein Banding Virus-Encoded Proteins and Their Interactions: Implications in Potyvirus Infection

• Infectious Disease

Jill Bouchard

Contributing editor, Condensates.com

Here's an interesting review about how a plant virus uses its IDPs for multiple functions... including helping them localize to various membraneless organelles.

Biological reviews of the Cambridge Philosophical Society

Drugs, host proteins and viral proteins: how their promiscuities shape antiviral design

• COVID-19
• Infectious Disease
• Transcription

Jill Bouchard

Contributing editor, Condensates.com

Interested in drugging condensates by targeting the IDPs inside? This review should give you a lot of good food for thought.

Chemical communications (Cambridge, England)

Perturbation of liquid droplets of P-granule protein LAF-1 by the antimicrobial peptide LL-III

• Infectious Disease
• Neurodegeneration
• Phase Separation
• Physics of Condensates

Must Read

Cell

Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response

• Infectious Disease
• Transcription

Viruses

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

• Infectious Disease
• Phase Separation

Cell

I Will Survive: How NPR1 Condensation Promotes Plant Cell Survival

• Infectious Disease
• Transcription

Jill Bouchard

Contributing editor, Condensates.com

Here’s the Preview article for the Cell paper about the new plant condensates.

Journal of cell science

Mammalian stress granules and P bodies at a glance

• Cancer
• Infectious Disease
• Neurodegeneration
• Phase Separation

Jill Bouchard

Contributing editor, Condensates.com

This review does a nice job of describing the similarities and differences between stress granules and P bodies... obviously one of their commonalities is LLPS ;)