Viruses
Most Recent
bioRxiv
Sterol scarcity primes p38 immune defenses through a TIR-1/SARM1 phase transition
mBio
Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication
Jill Bouchard
Editor in Chief, Condensates.com
This is the second of 2 papers this week that discuss the role of P bodies in viral infections. Check out the other about P body disassembly during Kaposi’s sarcoma-associated herpesvirus infection.
BioRxiv
The NDP52/CALCOCO2 selective autophagy receptor controls processing body disassembly
Jill Bouchard
Editor in Chief, Condensates.com
This is the first of 2 papers this week that discuss the role of P bodies in viral infections. Check out the other paper about P bodies and influenza A virus replication here.
Journal of virology
EV71 2A Protease inhibits P-body formation to promote viral RNA synthesis
Jill Bouchard
Editor in Chief, Condensates.com
I see a lot of interesting work about the role of stress granules in viral infections. This work looks at P bodies. Check out this paper for a fresh take on condensates in infections.
Nature reviews Molecular cell biology
Targeting viruses in their phase
Jill Bouchard
Editor in Chief, Condensates.com
Here's the Research Highlight on two recent Nature papers about using drugs targeting condensates to fight viruses. Find links to them below: Nat Cell Biol paper about targeting LLPS in SARS-CoV-2 Nature paper about a condensate-hardening drug against RSV
Frontiers in plant science
Mapping of Functional Subdomains in the at ALKBH9B m 6 A-Demethylase Required for Its Binding to the Viral RNA and to the Coat Protein of Alfalfa Mosaic Virus
Jill Bouchard
Editor in Chief, Condensates.com
This paper looks at a protein's role in siRNA bodies, a condensate involved in plant viral infections that may or may not be related to stress granules.
Journal of molecular cell biology
Multifaceted roles of centrosomes in development, health, and disease
bioRxiv
Condensate-mediated reactivation of mumps virus infection under stress
Nature cell biology
Targeting liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
PLoS pathogens
The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury
Jill Bouchard
Editor in Chief, Condensates.com
Here's yet another viral protein (a ds-RBP) that affects stress granules in order to evade the immune response.
Nature
A condensate-hardening drug blocks RSV replication in vivo
Biophysical journal
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
Jill Bouchard
Editor in Chief, Condensates.com
This paper explores computationally how LLPS-promoting parts of a genome need to be positioned in order to promote genome packaging.
Hepatology (Baltimore, Md)
SLU7 prevents oxidative stress-mediated HNF4α degradation preserving hepatic differentiation and protecting from liver damage
Jill Bouchard
Editor in Chief, Condensates.com
Here's a new protein identified to be important for stress granule functions in liver cells.
Cells
New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections
Chemistry (Weinheim an der Bergstrasse, Germany)
Remodeling of the Fibrillation Pathway of α-Synuclein by Interaction with Antimicrobial Peptide LL-III
Jill Bouchard
Editor in Chief, Condensates.com
Ooh, check it out! This antimicrobial peptide stabilizes droplet forms of α-syn, at the expense of fibrils.
Journal of immunology (Baltimore, Md : 1950)
TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly
eLife
Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity
Jill Bouchard
Editor in Chief, Condensates.com
Here's another way viruses target stress granules to evade the immune response.
bioRxiv
Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids
Molecular biology
mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts
Jill Bouchard
Editor in Chief, Condensates.com
Here's a very interesting review that discusses how condensates contribute to the translation of mRNA outside of the ER.