Current opinion in cell biology
Most Recent
bioRxiv
PARprolink: a photoaffinity probe for identifying poly(ADP-ribose)-binding proteins
Jill Bouchard
Contributing editor, Condensates.com
Not only did these authors develop a new method to identify PAR-binding proteins, they also found them to be enriched in condensates. Read further to find out which ones.
bioRxiv
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells
ACS central science
Formation of Biomolecular Condensates in Bacteria by Tuning Protein Electrostatics
Journal of neurochemistry
The multi-functional RNA binding protein G3BP1 and its potential implication in neurodegenerative disease
Jill Bouchard
Contributing editor, Condensates.com
This review covers G3BP1's role in phase separation and the formation of stress granules in looking for clues for how to target it therapeutically.
Open biology
The role of disorder in RNA binding affinity and specificity
FACULTY POSITION IN MOLECULAR THERAPEUTICS
Fox Chase Cancer Center | Philadelphia, PA, USA
ApplybioRxiv
The prevalence and distribution in genomes of low-complexity, amyloid-like, reversible, kinked segment (LARKS), a common structural motif in amyloid-like fibrils
Feb
22
BPS 2021: 65th Biophysical Society Annual Meeting
Monday, February 22, 2021
Journal of proteomics
Identification of the interactomes associated with SCD6 and RBP42 proteins in Leishmania braziliensis
Jill Bouchard
Contributing editor, Condensates.com
It looks like these interactomes may be important for understanding how RNA granules participate in the gene regulation of certain parasites. The authors even mention that these insights may be key to therapeutic intervention.
Cell Reports
Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast
Nature reviews Genetics
RNA-binding proteins in human genetic disease
Frontiers in oncology
Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells
Nature medicine
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
Cells
Divide and Rule: Phase Separation in Eukaryotic Genome Functioning
Critical reviews in biochemistry and molecular biology
Human de novo purine biosynthesis
Jill Bouchard
Contributing editor, Condensates.com
Here's a review discussing recent evidence showing that the purinosomes are condensates.
Nature reviews Molecular cell biology
A framework for understanding the functions of biomolecular condensates across scales
Nature communications
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
Jill Bouchard
Contributing editor, Condensates.com
Interesting, it looks like both stress granules and Q-bodies play a role in sequestering misfolded proteins during starvation.
Biochemical pharmacology
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly
Neurochemical research
ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics
Jill Bouchard
Contributing editor, Condensates.com
Considering the phase separation propensity of SOD1 and TIA-1, these results may be worth seeing to help put all the pieces in the puzzle.