Trends in biochemical sciences
Most Recent
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
Scientific reports
Comparative Analysis of MACROD1, MACROD2 and TARG1 Expression, Localisation and Interactome
Jill Bouchard
Contributing editor, Condensates.com
These proteins appear to be important regulators of nucleoli and stress granules.
Aging cell
AMPK-mediated Formation of Stress Granules Is Required for Dietary Restriction-Induced Longevity in Caenorhabditis Elegans
Jill Bouchard
Contributing editor, Condensates.com
I find the interplay between starvation/dietary restriction, stress-granules, and aging quite fascinating.
International journal of molecular sciences
Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 With MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting article discussing the relationship between miRNA and the mislocalization of proteins associated with neurodegeneration.
Kitchen Table Talk
Liam Holt on Crowding and Compression
Theranostics
Discrete Functional and Mechanistic Roles of Chromodomain Y-like 2 (CDYL2) Transcript Variants in Breast Cancer Growth and Metastasis
Jill Bouchard
Contributing editor, Condensates.com
It looks like certain isoforms of the CDYL2 protein stick to condensates in breast cancer cells affecting proliferation, migration and invasion.
Kitchen Table Talk
Magnus Kjærgaard on Tethered Enzymes, Multivalent Interactions—and Tigers
Kitchen Table Talk
Priya Banerjee on Phase Transition and Hollow Condensates
Kitchen Table Talk
Dominique Weil on mRNA Storage in Human P-bodies
Cell
G3BP1 Is a Tunable Switch That Triggers Phase Separation to Assemble Stress Granules
Jill Bouchard
Contributing editor, Condensates.com
Here's a great example of how IDRs can fine-tune the formation of RNP condensates.
Kitchen Table Talk
Jeanne Stachowiak on Disordered Proteins and Membrane Traffic
Molecular biology of the cell
Reorganization of Budding Yeast Cytoplasm Upon Energy Depletion
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting study on how condensates are involved in yeast survival skills.
Metabolism: clinical and experimental
The Impact of Hyperglycaemia on PKM2-mediated NLRP3 Inflammasome/Stress Granule Signalling in Macrophages and Its Correlation With Plaque Vulnerability: An in Vivo and in Vitro Study
Jill Bouchard
Contributing editor, Condensates.com
This is an interesting link between hyperglycemia and stress granules.
International journal of molecular sciences
DDX6 Helicase Behavior and Protein Partners in Human Adipose Tissue-Derived Stem Cells During Early Adipogenesis and Osteogenesis
Jill Bouchard
Contributing editor, Condensates.com
This is an interesting look at RNP condensates throughout the cell cycle of fat-derived stem cells.
Current opinion in cell biology
Nuclear Hubs Built on RNAs and Clustered Organization of the Genome
Jill Bouchard
Contributing editor, Condensates.com
This review discusses the role of RNA in nuclear compartmentalization...mostly condensates.
Proceedings of the National Academy of Sciences of the United States of America
Nonclassical Nuclear Localization Signals Mediate Nuclear Import of CIRBP
Jill Bouchard
Contributing editor, Condensates.com
Its's so interesting that RG and RSY motifs can not only phase separate but also behave as non-classical nuclear localization signals!
Journal of cell science
SNAP29 Mediates the Assembly of Histidine-Induced CTP Synthase Filaments in Proximity to the Cytokeratin Network
Journal of molecular biology
Liquid-Liquid Phase Separation and Its Mechanistic Role in Pathological Protein Aggregation
Proceedings of the National Academy of Sciences of the United States of America
TDP-43 α-Helical Structure Tunes Liquid-Liquid Phase Separation and Function
Jill Bouchard
Contributing editor, Condensates.com
Cool stuff: enhancing the helicity of one section in TDP-43 increases function and self-assembly/rigidity of condensates.