Biological chemistry
Most Recent
International journal of molecular sciences
RNA-Binding Proteins and the Complex Pathophysiology of ALS
Jill Bouchard
Managing editor, Condensates.com
Here's a nice review about the role of mutations in RNA-binding proteins that causes dysfunction of various membraneless organelles.
Antiviral research
Proteomic Analysis Identifies the RNA Helicase DDX3X as a Host Target Against SARS-CoV-2 Infection
Jill Bouchard
Managing editor, Condensates.com
Here's some interesting new data reporting on the role of stress granules in SARS-CoV-2 infection.
Science advances
LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation
Nature cell biology
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis
The Journal of cell biology
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation
Cellular and molecular life sciences : CMLS
Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS
The FEBS journal
Biological implications of decapping: beyond bulk mRNA decay
Jill Bouchard
Managing editor, Condensates.com
Here's a review discussing the intricate interaction between P bodies and RNA metabolism.
bioRxiv
Identification of the Rigid Core for Aged Liquid Droplets of the TDP-43 Low Complexity Domain
BioRxiv
Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress
Jill Bouchard
Managing editor, Condensates.com
I'm not surprised that pathological and physiological stress granules have very different proteomes. These differences may inform ways to selectively treat the bad ones.
bioRxiv
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation
Genes to cells : devoted to molecular & cellular mechanisms
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells
Journal of the American Chemical Society
Identifying Poly(ADP-ribose)-Binding Proteins with Photoaffinity-Based Proteomics
Jill Bouchard
Managing editor, Condensates.com
I have a feeling we'll be seeing more reports of interactions between PAR and condensates in the not so distant future, and this method could certainly help find them.
bioRxiv
Pak1 kinase regulates ribonucleoprotein granules through Sts5 for polarized growth and the glucose starvation response
Jill Bouchard
Managing editor, Condensates.com
Here's an interesting study showing the effects of phosphorylation on an IDP's ability to localize with P bodies.
Journal of chemical information and modeling
Recent Force Field Strategies for Intrinsically Disordered Proteins
Experimental cell research
Cellular metabolic stress responses via organelles
Jill Bouchard
Managing editor, Condensates.com
This review covers both membrane-bound and membraneless organelles.
Current opinion in cell biology
The role of liquid-liquid phase separation in regulating enzyme activity
Current opinion in cell biology
Phosphorylation-dependent regulation of messenger RNA transcription, processing and translation within biomolecular condensates
Current opinion in cell biology
Noise buffering by biomolecular condensates in glucose sensing
bioRxiv
PARprolink: a photoaffinity probe for identifying poly(ADP-ribose)-binding proteins
Jill Bouchard
Managing editor, Condensates.com
Not only did these authors develop a new method to identify PAR-binding proteins, they also found them to be enriched in condensates. Read further to find out which ones.