Most Recent
Nature communications
Contributing editor, Condensates.com
Interesting, it looks like both stress granules and Q-bodies play a role in sequestering misfolded proteins during starvation.
Biochemical pharmacology
Neurochemical research
Contributing editor, Condensates.com
Considering the phase separation propensity of SOD1 and TIA-1, these results may be worth seeing to help put all the pieces in the puzzle.
Molecular reproduction and development
Contributing editor, Condensates.com
Here's a nice biophysical analysis of the phase separation of a couple proteins involved in transcription.
International journal of molecular sciences
International journal of molecular sciences
Contributing editor, Condensates.com
This review also mentions how phase separation is involved.
World journal of gastroenterology
Current opinion in plant biology
Nature Communications
Contributing editor, Condensates.com
This article shows how yeast use condensates to store metabolic supplies when oxygen consumption and pH are lower so they can quickly access them when conditions are right again.
Biochimica et biophysica acta Molecular basis of disease
Contributing editor, Condensates.com
ICYMI, hypusine is an uncommon PTM on lysine, which causes interesting interactions between this translation initiation factor and proteins involved in 2 condensates (both stress granules and the nuclear pore complex).
bioRxiv
Biophysical journal
BioRxiv
Developmental cell
bioRxiv
The international journal of biochemistry & cell biology
Contributing editor, Condensates.com
Understanding how these proteins gain cytoplasmic functions and lose nuclear functions may help us figure out how to target condensates to restore balance.
Nature Reviews, Microbiology
Contributing editor, Condensates.com
The authors cover both membrane-bound and membrane-less organelles...should be a good read.
Annals of clinical and translational neurology
Contributing editor, Condensates.com
These authors found a continuum of phenotypes in the mislocalization of RNA-binding proteins in MS neurons. Understanding the patterns (and how stress granules are involved) will help shed light on disease progression and severity.
The Journal of cell biology
Contributing editor, Condensates.com
Cool--These authors found an important regulator of stress granules. Elevating its levels reduced TDP-43 positive SGs in ALS-derived neurons.
Plant physiology
Contributing editor, Condensates.com
What makes proteins involved in RNA metabolism localize to nuclear speckles? And what exactly do they do there? Read within to find out.