bioRxiv
Most Recent
The international journal of biochemistry & cell biology
“STRESSED OUT”: The Role of FUS and TDP-43 in Amyotrophic lateral sclerosis
Jill Bouchard
Contributing editor, Condensates.com
Understanding how these proteins gain cytoplasmic functions and lose nuclear functions may help us figure out how to target condensates to restore balance.
Nature Reviews, Microbiology
Formation and function of bacterial organelles
Jill Bouchard
Contributing editor, Condensates.com
The authors cover both membrane-bound and membrane-less organelles...should be a good read.
Annals of clinical and translational neurology
Neuronal RNA-binding Protein Dysfunction in Multiple Sclerosis Cortex
Jill Bouchard
Contributing editor, Condensates.com
These authors found a continuum of phenotypes in the mislocalization of RNA-binding proteins in MS neurons. Understanding the patterns (and how stress granules are involved) will help shed light on disease progression and severity.
The Journal of cell biology
Conserved Metabolite Regulation of Stress Granule Assembly via AdoMet
Jill Bouchard
Contributing editor, Condensates.com
Cool--These authors found an important regulator of stress granules. Elevating its levels reduced TDP-43 positive SGs in ALS-derived neurons.
Plant physiology
An SMU Splicing Factor Complex Within Nuclear Speckles Contributes to Magnesium Homeostasis in Arabidopsis Thaliana
Jill Bouchard
Contributing editor, Condensates.com
What makes proteins involved in RNA metabolism localize to nuclear speckles? And what exactly do they do there? Read within to find out.
Nature chemical biology
Formation and Functionalization of Membraneless Compartments in Escherichia Coli
The FEBS journal
Novel FMRP Interaction Networks Linked to Cellular Stress
Jill Bouchard
Contributing editor, Condensates.com
It looks like this protein interacts with many other proteins in condensates. I wonder if that means this one shuttles between various condensates?
Cellular and molecular life sciences : CMLS
Stress Granule Subtypes: An Emerging Link to Neurodegeneration
Trends in biochemical sciences
Mechanisms and Regulation of RNA Condensation in RNP Granule Formation
BioRxiv
A localization screen reveals translation factories and widespread co-translational RNA targeting
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
Scientific reports
Comparative Analysis of MACROD1, MACROD2 and TARG1 Expression, Localisation and Interactome
Jill Bouchard
Contributing editor, Condensates.com
These proteins appear to be important regulators of nucleoli and stress granules.
Aging cell
AMPK-mediated Formation of Stress Granules Is Required for Dietary Restriction-Induced Longevity in Caenorhabditis Elegans
Jill Bouchard
Contributing editor, Condensates.com
I find the interplay between starvation/dietary restriction, stress-granules, and aging quite fascinating.
International journal of molecular sciences
Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 With MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting article discussing the relationship between miRNA and the mislocalization of proteins associated with neurodegeneration.
Kitchen Table Talk
Liam Holt on Crowding and Compression
Theranostics
Discrete Functional and Mechanistic Roles of Chromodomain Y-like 2 (CDYL2) Transcript Variants in Breast Cancer Growth and Metastasis
Jill Bouchard
Contributing editor, Condensates.com
It looks like certain isoforms of the CDYL2 protein stick to condensates in breast cancer cells affecting proliferation, migration and invasion.
Kitchen Table Talk
Magnus Kjærgaard on Tethered Enzymes, Multivalent Interactions—and Tigers
Kitchen Table Talk
Priya Banerjee on Phase Transition and Hollow Condensates
Kitchen Table Talk