Postdoctoral Research Associate in Cell Biology/Biophysics of Biomolecular Condensates
St. Jude Children's Research Hospital | Memphis, TN USA
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Group Leader/Assoc. Director – Target ID/Interactome Mapping
Dewpoint Therapeutics | Boston, MA USA
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University of Oxford | Oxford, United Kingdom
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Research Associate, Cell Biology (m/f/d)
Dewpoint Therapeutics | Dresden, Germany
ApplyBiochemical and biophysical research communications
Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion
Jill Bouchard
Contributing editor, Condensates.com
This looks like a good method for those folks out there studying the phase separation of chromatin and various proteins involved in its regulation.
Proteomics
Emerging Role of Mass Spectrometry-Based Structural Proteomics in Elucidating Intrinsic Disorder in Proteins
Jill Bouchard
Contributing editor, Condensates.com
I wonder if these methods help overcome challenges in collecting information about IDPs in condensates?
Current protocols in plant biology
The Isolation of Stress Granules From Plant Material
Molecular & cellular oncology
Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Jill Bouchard
Contributing editor, Condensates.com
Here's a comment on a previous paper the authors published, which they speculate may involve phase separation--I bet they have a long list of experiments planned to test this.
The journal of physical chemistry B
Protein-Peptide Binding Energetics under Crowded Conditions
Jill Bouchard
Contributing editor, Condensates.com
Given that phase separation also crowds molecules, this work serves as a cautionary note for condensates studies too.
The journal of physical chemistry B
Unraveling Molecular Interactions in Liquid-Liquid Phase-Separation of Disordered Proteins by Atomistic Simulations
PhD student
Wageningen University | Wageningen, Netherlands
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UCSF | San Francisco, CA
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Open Force Field Consortium | flexible location
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University at Buffalo | Buffalo, New York
ApplybioRxiv
SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA
Proceedings of the National Academy of Sciences of the United States of America
Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids
Jill Bouchard
Contributing editor, Condensates.com
Here's a deep dive into what drives solid and gel phases--looks like a pretty thorough use of a bunch of biophysical methods.
Postdoc in Ultrahigh throughput exploration of protein aggregation and assembly sequence space
Technical University of Denmark (DTU) | Lyngby, Denmark
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ATP Kinetically Modulates Pathogenic Tau Fibrillations
Jill Bouchard
Contributing editor, Condensates.com
This is another piece of work showing how important small molecules are for modulating the various phases in cells.
Biophysical journal