Multiple positions in the Lab for Synthetic Macromolecular Assemblies
George Lu Lab @ Rice University | Houston, TX
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Target ID/Interactome Mapping-Group Leader PhD
Dewpoint Therapeutics | Boston, MA USA
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Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells
Jill Bouchard
Contributing editor, Condensates.com
It looks like dengue viral capsid phase separates and joins the nucleolus as part of it's invasion strategy... another way (of the many) that viruses use our condensates against us.
The Journal of Biological Chemistry
Phase-separated Condensate-Aided Enrichment of Biomolecular Interactions for High-Throughput Drug Screening in Test Tubes
Journal of molecular cell biology
The Protective Role of m1A During Stress-Induced Granulation
Jill Bouchard
Contributing editor, Condensates.com
Here's the second article this week showing a role of mRNA methylation in condensate formation... only this time it's m1A (where the N1 A gets post-transcriptionally modified).
Protein & cell
Live Cell Imaging and Proteomic Profiling of Endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated Knock-In
Jill Bouchard
Contributing editor, Condensates.com
Cool. Here's a new method to track endogenous lncRNA in cells and identify proteins it may interact with, whereby they identified new proteins in paraspeckles.
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
BioRxiv
Nuclear phosphatidylinositol 3,4,5-trisphosphate interactome uncovers an enrichment in nucleolar proteins
Jill Bouchard
Contributing editor, Condensates.com
It's cool to see important lipid signaling molecules show up in condensates!
Nature Methods
Cell Biology Befriends Soft Matter Physics
BioRxiv
Integrated multi-omics reveals common properties underlying stress granule and P-body formation
Assistant Professor of Biological Neurochemistry (Tenure Track)
Radboud University | Nijmegen, Netherlands
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PlaToLoCo: The First Web Meta-Server for Visualization and Annotation of Low Complexity Regions in Proteins
Jill Bouchard
Contributing editor, Condensates.com
Do you have a phase-separating protein that looks like it may have an LCD? You can use this online platform to check into it.I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/platoloco/
3 funded PhD positions on the Role of phase separation mechanisms in higher-order chromatin organization during development
Université de Montpellier | Montpellier, France
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Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
bioRxiv
Unraveling molecular interactions in a phase-separating protein by atomistic simulations
bioRxiv
Preferred Conformations in the Intrinsically Disordered Region of Human CPEB3 Explain its Role in Memory Consolidation
Jill Bouchard
Contributing editor, Condensates.com
This work takes a careful look at the roles of specific motifs and residues (mainly poly-Q vs poly-P-II vs VG-repeats) in functional vs pathological amyloids.
Physical review E
Active Suppression of Ostwald Ripening: Beyond Mean-Field Theory
Jill Bouchard
Contributing editor, Condensates.com
Do you ever wonder why all the condensates in cells don't fuse into one big one? This review discusses the different physical forces at play.
Nature
Composition-dependent Thermodynamics of Intracellular Phase Separation
bioRxiv
Phe-Gly Motifs Drive Fibrillization of TDP-43’s Prion-Like Domain Droplets
Jill Bouchard
Contributing editor, Condensates.com
I find it very interesting that the outer edges of droplets nucleated fibrils.
Proceedings of the National Academy of Sciences of the United States of America