Is your favorite condensate the NPC? If so, here's a treat for you. If not, this study highlights some methods that could be very helpful to study the structure-function relationships within other condensates.

Science advances

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

Jill Bouchard

Contributing editor, Condensates.com

Studying degradation inside condensates is becoming more common. Here's an example of the thorough use of complementary methods it might take to get all the details.

Briefings in bioinformatics

Proteome-scale analysis of phase-separated proteins in immunofluorescence images

Physical chemistry chemical physics : PCCP

Towards molecular movies with X-ray photon correlation spectroscopy

Jill Bouchard

Contributing editor, Condensates.com

Here's a nice perspective discussing how to apply new methods to study condensates!

Journal of chemical information and modeling

Comprehensive Structural and Thermodynamic Analysis of Pre-Fibrillar WT α-Synuclein and its G51D, E46K and A53T Mutants by a Combination of Small-Angle X-Ray Scattering and Variational Bayesian Weighting

Jill Bouchard

Contributing editor, Condensates.com

I wonder if this method could also be applied to predicting other types of phase separation, such as LLPS

International journal of molecular sciences

Development of Charge-Augmented Three-Point Water Model (CAIPi3P) for Accurate Simulations of Intrinsically Disordered Proteins

Jill Bouchard

Contributing editor, Condensates.com

Having problems simulating a condensate-loving IDP? Maybe your water model needs updating.

Journal of the American Chemical Society

bioRxiv

Methods

Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids

Jill Bouchard

Postdoc in Ultrahigh throughput exploration of protein aggregation and assembly sequence space

ATP Kinetically Modulates Pathogenic Tau Fibrillations

Jill Bouchard

Sequence Effects on Internal Structure of Droplets of Associative Polymers

Identification of Small Molecules that Modulate Mutant p53 Condensation

Pulsed electric fields induce modulation of protein liquid-liquid phase separation

ODiNPred: comprehensive prediction of protein order and disorder

Jill Bouchard

Microanalysis of Single Poly(N-isopropylacrylamide) Droplet Produced by an Optical Tweezer in Water: Isotacticity Dependence of Growth and Chemical Structure of the Droplet

Jill Bouchard

Tenure-Track Assistant Professor of Physical Chemistry, Specialising in Solid-state NMR Spectroscopy

In-cell architecture of the nuclear pore and snapshots of its turnover

Jill Bouchard

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

Jill Bouchard

Proteome-scale analysis of phase-separated proteins in immunofluorescence images

Towards molecular movies with X-ray photon correlation spectroscopy

Jill Bouchard

Comprehensive Structural and Thermodynamic Analysis of Pre-Fibrillar WT α-Synuclein and its G51D, E46K and A53T Mutants by a Combination of Small-Angle X-Ray Scattering and Variational Bayesian Weighting

Jill Bouchard

Development of Charge-Augmented Three-Point Water Model (CAIPi3P) for Accurate Simulations of Intrinsically Disordered Proteins

Jill Bouchard

Conformational ensembles of an intrinsically disordered protein consistent with NMR, SAXS and single-molecule FRET

Jill Bouchard

2 Assistant Professor positions in all areas of chemistry

RNA promotes the formation of spatial compartments in the nucleus

The Interplay between Phase Separation and Gene-Enhancer Communication: A Theoretical Study

IDPSIG and friends Virtual Symposium

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Intern, Administrative and Laboratory Operations (m/f/d)