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Must ReadVIDEO: SLAS Webinar–Biomolecular Condensates: A Novel Opportunity for Drug Discovery
bioRxiv
Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
bioRxiv
ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues
Science Translational Medicine
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
Jill Bouchard
Managing editor, Condensates.com
Here's a way to get misplaced proteins out of condensates.
Autophagy
Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?
The Journal of biological chemistry
Droplet and fibril formation of the functional amyloid Orb2
GeroScience
Regulation of TDP-43 phosphorylation in aging and disease
Jill Bouchard
Managing editor, Condensates.com
This review covers what regulation means for TDP-43 localization and phase separation.
Protein science : a publication of the Protein Society
FUS Oncofusion Protein Condensates Recruit mSWI/SNF Chromatin Remodeler via Heterotypic Interactions Between Prion-like Domains
Brain : a journal of neurology
Karyopherin abnormalities in neurodegenerative proteinopathies
Jill Bouchard
Managing editor, Condensates.com
This review focuses on the complex interplay between the dual functions of karyopherins--they're known for nuclear import/export, but they also act as chaperones of disease-related proteins that are prone to phase separate.
Frontiers in molecular biosciences
SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates?
Neuron
Tau heckles speckles: A pathogenic mechanism in tauopathy?
Jill Bouchard
Managing editor, Condensates.com
Here's the Preview article for the recent Neuron paper about how tau aggregates affect nuclear speckle components.
Jun
03
SLAS Webinar–Biomolecular Condensates: A Novel Opportunity for Drug Discovery
Thursday, June 3, 2021
ACS chemical neuroscience
C1 Inhibits Liquid-Liquid Phase Separation and Oligomerization of Tau and Protects Neuroblastoma Cells against Toxic Tau Oligomers
BioRxiv
Sequence Determinants of Human Junctophilin-2 Protein Nuclear Localization and Phase Separation
Journal of cell science
Amyloid Beta oligomers prevents Lysosomal targeting of miRNP to stop its recycling and target repression in glial cells
Jill Bouchard
Managing editor, Condensates.com
P bodies play a pretty interesting role in this process. Check out the paper for all the details.
Jun
07
Jun
07
Jun
23
Biochemist on Condensate Biology at Johns Hopkins
Johns Hopkins University | Baltimore, Maryland, USA
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