British journal of pharmacology
Targeting TDP-43 Proteinopathy With Drugs and Drug-Like Small Molecules
Jill Bouchard
Contributing editor, Condensates.com
This review covers how some drugs affect TDP-43 mislocalization.
Most Recent
Current opinion in cell biology
Karyopherins and Condensates
Journal of molecular cell biology
The Protective Role of m1A During Stress-Induced Granulation
Jill Bouchard
Contributing editor, Condensates.com
Here's the second article this week showing a role of mRNA methylation in condensate formation... only this time it's m1A (where the N1 A gets post-transcriptionally modified).
Chemistry (Weinheim an der Bergstrasse, Germany)
Alteration of the Conformational Dynamics of a DNA Hairpin by α-Synuclein in the Presence of Aqueous Two-Phase Systems
Jill Bouchard
Contributing editor, Condensates.com
This study applies pressure to a phase-separated neuro-protein interacting with DNA to understand how the DNA is altered long-term.
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
Nature Methods
Cell Biology Befriends Soft Matter Physics
The journal of physical chemistry letters
Single-Protein Collapse Determines Phase Equilibria of a Biological Condensate
Assistant Professor of Biological Neurochemistry (Tenure Track)
Radboud University | Nijmegen, Netherlands
ApplyNucleic acids research
PlaToLoCo: The First Web Meta-Server for Visualization and Annotation of Low Complexity Regions in Proteins
Jill Bouchard
Contributing editor, Condensates.com
Do you have a phase-separating protein that looks like it may have an LCD? You can use this online platform to check into it.I’ve saved it in our library of Resources–check it out here: https://condensates.com/resources/platoloco/
May
20
Proteostasis Consortium: Judith Frydman
Wednesday, May 20, 2020
bioRxiv
The low complexity motif of cytoplasmic polyadenylation element binding protein 3 (CPEB3) is critical for the trafficking of its targets in neurons
Jill Bouchard
Contributing editor, Condensates.com
Isn't it cool that the low complexity domain is required for P-body localization and affects long term memory?!
Trends in biochemical sciences
The Wide World of Coacervates: From the Sea to Neurodegeneration
Jill Bouchard
Contributing editor, Condensates.com
Check this out if you'd like to see how condensates contribute to the formation of fibrillar or crustaceous materials in marine life.
Proceedings of the National Academy of Sciences of the United States of America
Liquid-liquid Phase Separation of Type II Diabetes-Associated IAPP Initiates Hydrogelation and Aggregation
Jill Bouchard
Contributing editor, Condensates.com
Here's another study suggesting condensates initiate amyloid formation, except this is in the context of type II diabetes.
Nucleic Acids Research
G3BP1-linked mRNA Partitioning Supports Selective Protein Synthesis in Response to Oxidative Stress
bioRxiv
Preferred Conformations in the Intrinsically Disordered Region of Human CPEB3 Explain its Role in Memory Consolidation
Jill Bouchard
Contributing editor, Condensates.com
This work takes a careful look at the roles of specific motifs and residues (mainly poly-Q vs poly-P-II vs VG-repeats) in functional vs pathological amyloids.
iScience
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons Through an FMRP-Dependent Mechanism
Jill Bouchard
Contributing editor, Condensates.com
Here's an example of the tight regulation of stress granules which keeps neurons working properly.
International journal of molecular sciences
Connecting RNA-Modifying Similarities of TDP-43, FUS, and SOD1 With MicroRNA Dysregulation Amidst A Renewed Network Perspective of Amyotrophic Lateral Sclerosis Proteinopathy
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting article discussing the relationship between miRNA and the mislocalization of proteins associated with neurodegeneration.
BioRxiv
The Proline-rich Domain Promotes Tau Liquid Liquid Phase Separation in Cells
Molecular brain
Frameshift Peptides Alter the Properties of Truncated FUS Proteins in ALS-FUS
Jill Bouchard
Contributing editor, Condensates.com
This work compares how the 'peptide-tails' caused by frameshift disease mutations affect cellular localization.
bioRxiv
Phe-Gly Motifs Drive Fibrillization of TDP-43’s Prion-Like Domain Droplets
Jill Bouchard
Contributing editor, Condensates.com
I find it very interesting that the outer edges of droplets nucleated fibrils.