Aug
26
Proteostasis Consortium: Jim Shorter
Wednesday, August 26, 2020
Most Recent
Sep
02
Proteostasis Consortium: Brad Hyman
Wednesday, September 2, 2020
bioRxiv
Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.
Genes
The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization
Bio-protocol
Studying Protein Aggregation in the Context of Liquid-liquid Phase Separation Using Fluorescence and Atomic Force Microscopy, Fluorescence and Turbidity Assays, and FRAP
Kitchen Table Talk
Must ReadRohit Pappu on Molecular Grammar of Condensates – Part 2
Neurochemistry international
Pathophysiological Implications of RNP Granules in Frontotemporal Dementia and ALS
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice review on the biophysical properties of stress granules and paraspeckles in the hopes of finding a condensate-based therapy for neuodegenerative disorders.
bioRxiv
Molecular details of protein condensates probed by microsecond-long atomistic simulations
bioRxiv
Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
Laboratory Operations Assistant
Dewpoint Therapeutics | Boston, MA, USA
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Dewpoint Therapeutics | Boston, MA, USA
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“STRESSED OUT”: The Role of FUS and TDP-43 in Amyotrophic lateral sclerosis
Jill Bouchard
Contributing editor, Condensates.com
Understanding how these proteins gain cytoplasmic functions and lose nuclear functions may help us figure out how to target condensates to restore balance.
Scientist/ Senior Scientist for Cell Applications & Assay Development (m/f/d)
Dewpoint Therapeutics | Dresden, Germany
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Dewpoint Therapeutics | Boston, MA, USA
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The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis
bioRxiv
Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation
PLoS One
Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA
Jill Bouchard
Contributing editor, Condensates.com
These authors investigated whether phase separation plays a role in aggregate formation. Check it out to find out their answer.
International journal of molecular sciences
Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin
Jill Bouchard
Contributing editor, Condensates.com
This article suggests a potential cancer treatment: combining morusin with a stress granule inhibitor.
Angewandte Chemie (International ed in English)
Zooming into the Interaction of α-synuclein with Calcium Ions through Exclusively Heteronuclear NMR Experiments
Jill Bouchard
Contributing editor, Condensates.com
Ions play a significant role in the phase behavior of many proteins found in condensates. These methods may help investigate those interactions.
Proceedings of the National Academy of Sciences of the United States of America
Differences in the free energies between the excited states of A β 40 and A β 42 monomers encode their aggregation propensities
Jill Bouchard
Contributing editor, Condensates.com
Using the population of excited states to empirically calculate the aggregation propensity could be a useful approach for predicting whether certain proteins will aggregate in condensates.