Neuron
Most Recent
Frontiers in cellular neuroscience
Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD
Jun
02
Emily Sontag on Sorting out the JUNQ: the Spatial Nature of Protein Quality Control
Wednesday, June 2, 2021
Apr
06
Online Conference on Phase Separated Systems in the Nucleus
Tuesday, April 6, 2021
May
26
VIRTUAL: UK DRI Mechanistic insights into the pathophysiology of ALS
Wednesday, May 26, 2021
Oct
18
Protein phase transitions in ageing and age-related diseases: from atomic resolution to cellular solutions
Monday, October 18, 2021 | Roscoff, France
International journal of molecular sciences
Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation
Jill Bouchard
Managing editor, Condensates.com
Here's a new optogenetics method to use for a stress granule protein; I hope it can be useful for others too.
International journal of molecular sciences
RNA-Binding Proteins and the Complex Pathophysiology of ALS
Jill Bouchard
Managing editor, Condensates.com
Here's a nice review about the role of mutations in RNA-binding proteins that causes dysfunction of various membraneless organelles.
BioRxiv
Two timescales control the creation of large protein aggregates in cells
Jill Bouchard
Managing editor, Condensates.com
The authors mention this work could have implications for condensates. Read on to find out why!
bioRxiv
An improved molecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under pathological conditions.
Journal of Physical Chemistry Letters
Ultrasensitive Characterization of the Prion Protein by Surface-Enhanced Raman Scattering: Selective Enhancement via Electrostatic Tethering of the Intrinsically Disordered Domain with Functionalized Silver Nanoparticles
Jill Bouchard
Managing editor, Condensates.com
Here's a new way to look at the dilute phase of your favorite phase separating IDP.
Kitchen Table Talk
Must ReadVIDEO: Shana Elbaum-Garfinkle on Emergent Material Properties of Biomolecular Condensates
Caltech professor Ibrahim Cissé applies physics to decode and understand RNA transcription
Apr
14
Proteostasis Consortium: Alwin Köhler
Wednesday, April 14, 2021
Archives of biochemistry and biophysics
Glycine rich segments adopt polyproline II helices: Implications for biomolecular condensate formation
Journal of molecular biology
Synapsin Condensates Recruit alpha-Synuclein
Antiviral research
Proteomic Analysis Identifies the RNA Helicase DDX3X as a Host Target Against SARS-CoV-2 Infection
Jill Bouchard
Managing editor, Condensates.com
Here's some interesting new data reporting on the role of stress granules in SARS-CoV-2 infection.
Osteoarthritis and cartilage
TDP-43 maintains chondrocyte homeostasis and alleviates cartilage degradation in osteoarthritis
Jill Bouchard
Managing editor, Condensates.com
This paper implicates stress granules in arthritis via TDP-43 regulation.
Journal of molecular biology
Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrils
Jill Bouchard
Managing editor, Condensates.com
And this work also shows that α-Syn modulates the liquid phase behavior of TDP-43 and RNA.
Frontiers in chemistry
Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins
Jill Bouchard
Managing editor, Condensates.com
Are you out of ideas for how to probe the fuzzy interactions of a condensate-loving IDP? Maybe this review (and mass spec) can help.