Aug
05
IDPSeminars: Rebecca Beveridge & Carlos CastaƱeda — August 5
Thursday, August 5, 2021
Most Recent
Postdoctoral Fellowship on Phase Separation in Amyloid Protein Systems
University of Copenhagen | Copenhagen, Denmark
ApplyJCI insight
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation
Journal of the American Chemical Society
Different Folding States from the Same Protein Sequence Determine Reversible vs Irreversible Amyloid Fate
Jill Bouchard
Managing editor, Condensates.com
This work argues amyloids can be reversible and irreversible.
Professor Anthony Hyman is a new member of the Leopoldina
Frontiers in molecular biosciences
Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis
Frontiers in genetics
A Time-Resolved Diffusion Technique for Detection of the Conformational Changes and Molecular Assembly/Disassembly Processes of Biomolecules
Molecular genetics & genomic medicine
SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease
Jill Bouchard
Managing editor, Condensates.com
It looks like this protein may have a cell-cycle dependent localization between stress granules and DNA damage loci.
bioRxiv
Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington disease progression
Nucleic Acids Research
Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases
Jill Bouchard
Managing editor, Condensates.com
This review is full of a lot of juicy details about the role of RNA in phase separation.
Cell Research
Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation
Biochemical and biophysical research communications
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2
Jill Bouchard
Managing editor, Condensates.com
It's always the IDRs (ok, not always, but a lot of times!) that play key roles in condensate interactions.
Frontiers in aging neuroscience
Stress Granules and Neurodegenerative Disorders: A Scoping Review
Jill Bouchard
Managing editor, Condensates.com
This looks to be quite the comprehensive review of studies on the relationship between stress granules and neurodegeneration.
iScience
The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43
Nucleic acids research
The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
Kitchen Table Talk
Must ReadVIDEO: Shahar Sukenik on Turning Protein Disorder into Function: Is the Solution the Solution?
Jul
08
IDPSeminars: Silvio Tosatto & Sara Linse — July 8
Thursday, July 8, 2021
Nature reviews Immunology
Phase separation in immune signalling
Methods in molecular biology (Clifton, NJ)
Engineering Hydrogel Production in Mammalian Cells to Synthetically Mimic RNA Granules
Scientific Reports