Postdoctoral Fellowship on Phase Separation in Amyloid Protein Systems
University of Copenhagen | Copenhagen, Denmark
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Nature communications
A multi-step nucleation process determines the kinetics of prion-like domain phase separation
Brain research
Disease-associated mutations affect TIA1 phase separation and aggregation in a proline-dependent manner
Neuron
RNA modulates physiological and neuropathological protein phase transitions
Journal of molecular biology
Dynamic and reversible aggregation of the human CAP superfamily member GAPR-1 in protein inclusions in Saccharomyces cerevisiae
Cell
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
Jill Bouchard
Managing editor, Condensates.com
It looks like increased number of stress granules may be an early sign of FTD.
Frontiers in cell and developmental biology
New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation
Frontiers in genetics
Roles of Phase Separation for Cellular Redox Maintenance
Oxidative medicine and cellular longevity
Gasotransmitter CO Attenuates Bleomycin-Induced Fibroblast Senescence via Induction of Stress Granule Formation
Jill Bouchard
Managing editor, Condensates.com
This could be a very interesting therapeutic use for stress granules: to prevent senescence.
JCI insight
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation
Jill Bouchard
Managing editor, Condensates.com
The mutations caused a range of effects on phase separation and stress granule dynamics.
Journal of the American Chemical Society
Different Folding States from the Same Protein Sequence Determine Reversible vs Irreversible Amyloid Fate
Jill Bouchard
Managing editor, Condensates.com
This work argues amyloids can be reversible and irreversible.
Science Advances
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
Professor Anthony Hyman is a new member of the Leopoldina
Acta neuropathologica
HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing
Jill Bouchard
Managing editor, Condensates.com
Spoiler alert for condensate fans: HnRNP K mislocalizes to cytoplasmic puncta that are not stress granules.
Frontiers in molecular biosciences
Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis
Frontiers in molecular neuroscience
Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective
Frontiers in genetics
A Time-Resolved Diffusion Technique for Detection of the Conformational Changes and Molecular Assembly/Disassembly Processes of Biomolecules
Jill Bouchard
Managing editor, Condensates.com
Here's a review that covers methods for determining the molecular mechanisms of many types of phase transitions.
Molecular genetics & genomic medicine
SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease
Jill Bouchard
Managing editor, Condensates.com
It looks like this protein may have a cell-cycle dependent localization between stress granules and DNA damage loci.
bioRxiv
Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington disease progression
Nucleic Acids Research
Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases
Jill Bouchard
Managing editor, Condensates.com
This review is full of a lot of juicy details about the role of RNA in phase separation.