Proceedings of the National Academy of Sciences of the United States of America
Most Recent
Nature communications
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Journal of molecular biology
Prion Protein Biology Through the Lens of Liquid-Liquid Phase Separation
BioRxiv
Emergence of order in condensates composed of multi-valent, multi-domain proteins
The journal of physical chemistry B
Liquid-Liquid Phase Separation: A Widespread and Versatile Way to Organize Aqueous Solutions
Jill Bouchard
Managing editor, Condensates.com
Here's the Preface for the fantastic virtual issue in a couple of Journals of Physical Chemistry about LLPS. Make sure to check out all the articles with the JPhysChem virtual issue tag.
Journal of the American Chemical Society
Pressure-Jump Kinetics of Liquid-Liquid Phase Separation: Comparison of Two Different Condensed Phases of the RNA-Binding Protein, Fused in Sarcoma
EMBO reports
Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties
ACS chemical neuroscience
Contrasting Effects of Ferric and Ferrous Ions on Oligomerization and Droplet Formation of Tau: Implications in Tauopathies and Neurodegeneration
Biochemistry
Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates
Kitchen Table Talk
Must ReadVIDEO: Lucia Strader on Condensation to Attenuate Transcriptional Activity in Plants
EMBO reports
The stress granule protein G3BP1 promotes pre-condensation of cGAS to allow rapid responses to DNA
The Journal of biological chemistry
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity
The Journal of biological chemistry
Proximity-dependent biotinylation detects associations between SARS coronavirus nonstructural protein 1 and stress granule-associated proteins
Jill Bouchard
Managing editor, Condensates.com
It looks like the SARS coronaviruses are similar to many other viruses in that they also hijack condensates. Take a look at this paper to find out the details.
Frontiers in cell and developmental biology
The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back
Jill Bouchard
Managing editor, Condensates.com
This review discusses the unexpected function of the G3BP1/2 proteins in mediating crosstalk between stress granules and lysosomes.
Genetics
The length scale of multivalent interactions is evolutionarily conserved in fungal and vertebrate phase-separating proteins
International journal of molecular sciences
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
Signal transduction and targeted therapy
Managing stress granule disassembly with ubiquitin and its cousin
Jill Bouchard
Managing editor, Condensates.com
Here's a Research Highlight about the two recent Science papers showing how ubiquitination of G3BP1 mediates stress granules and how ubiquitination is essential for heat-shock recovery.
CNS neuroscience & therapeutics
Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1
Nature structural & molecular biology
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads
bioRxiv