Protein science : a publication of the Protein Society
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RNA (New York, NY)
The role of stress-activated RNA-protein granules in surviving adversity
Jill Bouchard
Managing editor, Condensates.com
This chapter covers how phase separation is involved in the formation of both P bodies and stress granules.
bioRxiv
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
International journal of molecular sciences
Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD
Jill Bouchard
Managing editor, Condensates.com
This review has a whole section on how phase separation is involved in disease pathogenesis.
Nature neuroscience
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
Antioxidants (Basel)
The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS
EMBO reports
Get closer and make hotspots: liquid-liquid phase separation in plants
PLoS biology
Phe-Gly motifs drive fibrillization of TDP-43’s prion-like domain condensates
Journal of the American Chemical Society
Identification of the Rigid Core for Aged Liquid Droplets of an RNA-Binding Protein Low Complexity Domain
Biology
RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease
Jill Bouchard
Managing editor, Condensates.com
Here's a review that touches on the role of this family of proteins in RNA-containing granules, such as stress granules.
Acta neuropathologica communications
Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction
Jill Bouchard
Managing editor, Condensates.com
This could be a useful method for identifying pathogenic condensates.
bioRxiv
FUS Oncofusion Protein Condensates Recruit mSWI/SNF Chromatin Remodelers via Heterotypic Interactions Between Prion-like Domains
International journal of molecular sciences
Current Understanding of the Structure, Stability and Dynamic Properties of Amyloid Fibrils
Jill Bouchard
Managing editor, Condensates.com
This review has a section on the role of LLPS in amyloid formation.
bioRxiv
Ubiquitination of G3BP1 mediates stress granule disassembly in a stress-specific manner
Journal of Molecular Biology
Phase Separation in Biology & Disease: The next chapter
Frontiers in molecular biosciences
Characterization of Weak Protein Domain Structure by Spin-Label Distance Distributions
Jill Bouchard
Managing editor, Condensates.com
Do you need to find a new experiment to get at the molecular mechanisms of phase separation? Maybe EPR is worth a try.
Biomolecules
Liquid-Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
Molecular cancer research : MCR
TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation
Jill Bouchard
Managing editor, Condensates.com
This is an interesting story about the connection between a tumor suppressor and stress granules.
Amino acids
Taurine suppresses liquid-liquid phase separation of lysozyme protein
bioRxiv