Computational and structural biotechnology journal
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Chemical science
Observation of liquid-liquid phase separation of ataxin-3 and quantitative evaluation of its concentration in a single droplet using Raman microscopy
Chemical science
Sequestration within biomolecular condensates inhibits Aβ-42 amyloid formation
Chemical reviews
Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids
Jill Bouchard
Editor in Chief, Condensates.com
LLPS gets a brief mention in this review that mostly covers structural studies of solid phases.
Journal of neurochemistry
ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells
Cell reports
Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability
Laboratory investigation; a journal of technical methods and pathology
Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells
Jill Bouchard
Editor in Chief, Condensates.com
Here's a new method to study pathogenic phase transitions of TDP-43 in vivo.
Brain : a journal of neurology
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia
Jill Bouchard
Editor in Chief, Condensates.com
This paper looks into the molecular mechanism of compromised stress granule assembly.
Communications biology
ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues
Kitchen Table Talk
Must ReadVIDEO: Emily Sontag on Sorting out the JUNQ: the Spatial Nature of Protein Quality Control
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Dewpoint Therapeutics | Boston, MA, USA
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Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?
Webinar
Must ReadVIDEO: SLAS Webinar–Biomolecular Condensates: A Novel Opportunity for Drug Discovery
Nature structural & molecular biology
It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation
BioRxiv
Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity
Protein science : a publication of the Protein Society
Introduction: Biophysics of biomolecular condensates
Jill Bouchard
Editor in Chief, Condensates.com
This is a very nice introduction to the special issue of Protein Science on the Biophysics of Biomolecular Condensates. Check out all the associated papers with the Protein Science special issue tag.
The Journal of biological chemistry
The N-terminal domain of the prion protein is required and sufficient for liquid-liquid phase separation; a crucial role of the Aβ-binding domain
bioRxiv
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome
Jill Bouchard
Editor in Chief, Condensates.com
This work shows that genotoxic conditions cause a bunch of proteins to phase separate--both liquid and solid versions.
Protein Science : A Publication Of The Protein Society
An apparent core/shell architecture of polyQ aggregates in the aging Caenorhabditis elegans neuron
Frontiers in cell and developmental biology
The Integral Role of RNA in Stress Granule Formation and Function
Jill Bouchard
Editor in Chief, Condensates.com
RNA get a much needed shout-out in this review; it dives into how RNA phase separation contributes to stress granule formation.