Biophysical journal

Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments

Autophagy

The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

bioRxiv

The Glycolytic Protein Phosphofructokinase Dynamically Relocalizes into Subcellular Compartments with Liquid-like Properties in vivo

The Journal of biological chemistry

Granulins modulate liquid-liquid phase separation and aggregation of prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43

bioRxiv

Altered dynamics may drift pathological fibrillization in membraneless organelles

Journal of biomolecular NMR

13C APSY-NMR for sequential assignment of intrinsically disordered proteins

Neuron

Axons Gonna Ride ’til They Can’t No More

bioRxiv

Liquid-Liquid Phase Separation is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules

Cell reports

Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation

Medical hypotheses

Dysbiosis in Parkinson’s disease might be triggered by certain antibiotics

Neurodegeneration

Nucleus (Austin, Tex)

Hyperosmotic Stress: in situ Chromatin Phase Separation

bioRxiv

Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation

Journal of neuro-oncology

G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis

bioRxiv

Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation

Current opinion in neurobiology

Prion-like Properties of Tau Assemblies

The journal of physical chemistry letters

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells

ACS chemical neuroscience

Catalytic Prion-like Cross-talk between a key Alzheimer’s disease Tau-fragment R3 and the Type 2 Diabetes peptide IAPP

ACS chemical neuroscience

A Hybrid Model to Study Amyloid Cross-Toxicity

Neurodegeneration

bioRxiv

Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

Acta neuropathologica

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Neurodegeneration

Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments

The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

The Glycolytic Protein Phosphofructokinase Dynamically Relocalizes into Subcellular Compartments with Liquid-like Properties in vivo

Granulins modulate liquid-liquid phase separation and aggregation of prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43

Altered dynamics may drift pathological fibrillization in membraneless organelles

13C APSY-NMR for sequential assignment of intrinsically disordered proteins

Axons Gonna Ride ’til They Can’t No More

Liquid-Liquid Phase Separation is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules

Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation

Dysbiosis in Parkinson’s disease might be triggered by certain antibiotics

Hyperosmotic Stress: in situ Chromatin Phase Separation

Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation

G3BP1 knockdown sensitizes U87 glioblastoma cell line to Bortezomib by inhibiting stress granules assembly and potentializing apoptosis

Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation

Prion-like Properties of Tau Assemblies

Different Conformational Subensembles of the Intrinsically Disordered Protein α-Synuclein in Cells

Catalytic Prion-like Cross-talk between a key Alzheimer’s disease Tau-fragment R3 and the Type 2 Diabetes peptide IAPP

A Hybrid Model to Study Amyloid Cross-Toxicity

Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Senior Scientist – Neurological & Rare Diseases

Principal Scientist/Sr. Principal Scientist – Medicinal Chemistry

Senior Director, DMPK