Progress in molecular biology and translational science
Most Recent
Brain : a journal of neurology
Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS
Jill Bouchard
Editor in Chief, Condensates.com
Here's some interesting work on how the mislocalization of RNA-binding proteins affects the core-shell structure of paraspeckles.
Proceedings of the National Academy of Sciences of the United States of America
Intrinsically disordered linkers control tethered kinases via effective concentration
Jill Bouchard
Editor in Chief, Condensates.com
We were happy to host Magnus Kjærgaard at our virtual Kitchen Table to discuss these tethered linkers. (He had a great analogy about tigers :) )
Veterinary microbiology
Critical role for G3BP1 in infectious bursal disease virus (IBDV)-induced stress granule formation and viral replication
Jill Bouchard
Editor in Chief, Condensates.com
This clever virus exploits G3BP1's phase separation to harness stress granules for its replication.
Kitchen Table Talk
Must ReadVIDEO: Rohit Pappu on Molecular Grammar of Condensates – Part 3
Pharmacological research
Targeting stress granules: A novel therapeutic strategy for human diseases
Jill Bouchard
Editor in Chief, Condensates.com
Here's a nice review discussing how stress granules are involved in various diseases and may be targeted therapeutically.
Nanoscale
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils
Jill Bouchard
Editor in Chief, Condensates.com
Cool--a peptide forms "vesicular assemblies that accelerate fibril formation" and reduces cytotoxicity because it reduces the time pathogenic oligomers exist.
Neurobiology of disease
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress
Jill Bouchard
Editor in Chief, Condensates.com
These authors compared the interactomes of disease vs normal neurons to find out why stress granule formation is affected.
Biophysical chemistry
Disorder under stress: Role of polyol osmolytes in modulating fibrillation and aggregation of intrinsically disordered proteins
Jill Bouchard
Editor in Chief, Condensates.com
This looks like a careful biophysical study into how osmolytes affect different phase behaviors of IDPs.
Scientific Reports
Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
Jill Bouchard
Editor in Chief, Condensates.com
It's interesting that phase separation likely plays a role here.
BioRxiv
Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins
Aug
26
Proteostasis Consortium: Jim Shorter
Wednesday, August 26, 2020
Sep
02
Proteostasis Consortium: Brad Hyman
Wednesday, September 2, 2020
Analytical chemistry
The power of pure shift HαCα correlations: a way to characterize biomolecules under physiological conditions
Jill Bouchard
Editor in Chief, Condensates.com
Can't figure out how to get decent NMR spectra of your condensate-loving IDP? Try SHACA-HSQC.
Molecular cell
GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling
Molecular cell
An In Vitro Assembly System Identifies Roles for RNA Nucleation and ATP in Yeast Stress Granule Formation
Jill Bouchard
Editor in Chief, Condensates.com
Here's a nice method to help in the effort to understand the role of RNA in stress granule formation.
bioRxiv
Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.
Genes
The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization
Jill Bouchard
Editor in Chief, Condensates.com
This article is yet another example of how a single disease mutation in one protein can make a huge difference in the formation and function of a condensate.
Neurochemistry international
Pathophysiological Implications of RNP Granules in Frontotemporal Dementia and ALS
Jill Bouchard
Editor in Chief, Condensates.com
Here's a nice review on the biophysical properties of stress granules and paraspeckles in the hopes of finding a condensate-based therapy for neuodegenerative disorders.
Bio-protocol