BioRxiv
Most Recent
Transient droplets organize biochemical reactions inside cells
Molecular cell
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
Communications biology
Clustering of Human Prion Protein and α-synuclein Oligomers Requires the Prion Protein N-terminus
Jill Bouchard
Editor in Chief, Condensates.com
Uh oH... α-syn & prion protein can form micron-sized condensates together. On the bright side, it sounds like a pretty big drug target to me.
Emerging topics in life sciences
Arginine-rich Dipeptide-Repeat Proteins as Phase Disruptors in C9-ALS/FTD
Chemical Society Reviews
Half a Century of Amyloids: Past, Present and Future
Jill Bouchard
Editor in Chief, Condensates.com
This comprehensive review includes some discussion about the phases of amyloids.
International journal of biological macromolecules
Copper and Iron Ions Accelerate the Prion-Like Propagation of α-synuclein: A Vicious Cycle in Parkinson’s Disease
Jill Bouchard
Editor in Chief, Condensates.com
Here's another reminder that ions matter in phase separation!
bioRxiv
Tau conformers in FTLD-MAPT undergo liquid-liquid phase separation and perturb the nuclear envelope
Non-coding RNA
LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
Jill Bouchard
Editor in Chief, Condensates.com
This review discusses evidence that phase separation plays a role in the assembly of paraspeckles.
Biomaterials
Spatiotemporally Tracking of Nano-Biofilaments Inside the Nuclear Pore Complex Core
International journal of biological macromolecules
Nuclear Immunophilin FKBP39 From Drosophila Melanogaster Drives Spontaneous Liquid-Liquid Phase Separation
BioRxiv
ANTAGONISTIC ROLES FOR ATAXIN-2 STRUCTURED AND DISORDERED DOMAINS IN RNP CONDENSATION
Annals of clinical and translational neurology
Neuronal RNA-binding Protein Dysfunction in Multiple Sclerosis Cortex
Jill Bouchard
Editor in Chief, Condensates.com
These authors found a continuum of phenotypes in the mislocalization of RNA-binding proteins in MS neurons. Understanding the patterns (and how stress granules are involved) will help shed light on disease progression and severity.
The Journal of cell biology
Conserved Metabolite Regulation of Stress Granule Assembly via AdoMet
Jill Bouchard
Editor in Chief, Condensates.com
Cool--These authors found an important regulator of stress granules. Elevating its levels reduced TDP-43 positive SGs in ALS-derived neurons.
Scientific reports
Nusinersen Ameliorates Motor Function and Prevents Motoneuron Cajal Body Disassembly and Abnormal poly(A) RNA Distribution in a SMA Mouse Model
Jill Bouchard
Editor in Chief, Condensates.com
Here's an interesting study looking at how a neurodegeneration drug restores Cajal bodies.
Cancer science
Nuclear Microenvironment in Cancer: Control Through Liquid-Liquid Phase Separation
The Journal of cell biology
Liquid-liquid Phase Separation in Autophagy
mSystems
SynBio and the Boundaries Between Functional and Pathogenic RepA-WH1 Bacterial Amyloids
Jill Bouchard
Editor in Chief, Condensates.com
What can we learn from functional amyloids about how to harness the power of condensates? Perhaps this synthetic biology perspective will give us some insights.
Neural regeneration research
Prion-like Domain Disease-Causing Mutations and Misregulation of Alternative Splicing Relevance in Limb-Girdle Muscular Dystrophy (LGMD) 1G
Jill Bouchard
Editor in Chief, Condensates.com
This perspective discusses the effect disease mutations have on LLPS and subsequent aggregation.
Prion