bioRxiv
Most Recent
British journal of pharmacology
Targeting TDP-43 Proteinopathy With Drugs and Drug-Like Small Molecules
Jill Bouchard
Contributing editor, Condensates.com
This review covers how some drugs affect TDP-43 mislocalization.
Current opinion in cell biology
Karyopherins and Condensates
Molecular Cell
Sequence-Independent Self-Assembly of Germ Granule mRNAs Into Homotypic Clusters
Journal of molecular cell biology
The Protective Role of m1A During Stress-Induced Granulation
Jill Bouchard
Contributing editor, Condensates.com
Here's the second article this week showing a role of mRNA methylation in condensate formation... only this time it's m1A (where the N1 A gets post-transcriptionally modified).
The FEBS journal
The More the Merrier: Effects of Macromolecular Crowding on the Structure and Dynamics of Biological Membranes
Jill Bouchard
Contributing editor, Condensates.com
This review covers 2 types of condensates lipid-droplets and protein-phase separation at and near membranes. Check it out if you'd like to learn about the latest developments.
bioRxiv
A selective autophagy pathway for phase separated endocytic protein deposits
Small (Weinheim an der Bergstrasse, Germany)
Invasion and Defense Interactions Between Enzyme-Active Liquid Coacervate Protocells and Living Cells
Chemistry (Weinheim an der Bergstrasse, Germany)
Alteration of the Conformational Dynamics of a DNA Hairpin by α-Synuclein in the Presence of Aqueous Two-Phase Systems
Jill Bouchard
Contributing editor, Condensates.com
This study applies pressure to a phase-separated neuro-protein interacting with DNA to understand how the DNA is altered long-term.
BioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
BioRxiv
Membrane bending by protein phase separation
Cells
Protein Phase Separation During Stress Adaptation and Cellular Memory
Trends in biochemical sciences
Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria
bioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
Wiley interdisciplinary reviews RNA
Phase-separated Bacterial Ribonucleoprotein Bodies Organize mRNA Decay
Trends in biochemical sciences
Managing Hyperosmotic Stress Through Phase Separation
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice Spotlight article about a paper published in Nature earlier this year about the phase separation of the proteasome.
Macromolecular rapid communications
Recent Advances in Complex Coacervation Design From Macromolecular Assemblies and Emerging Applications
Jill Bouchard
Contributing editor, Condensates.com
This looks like quite the comprehensive review of phase separation because it addresses its application to so many different walks of life.
Nature Methods
Cell Biology Befriends Soft Matter Physics
The journal of physical chemistry letters