Biochemist, Postdoc
Institute of Molecular Biology | Mainz, Germany
ApplyMost Recent
bioRxiv
Consistent Force Field Captures Homolog Resolved HP1 Phase Separation
bioRxiv
Physical theory of biological noise buffering by multi-component phase separation
bioRxiv
Role of spatial patterning of N-protein interactions in SARS-CoV-2 genome packaging
Jill Bouchard
Contributing editor, Condensates.com
The authors looked into whether the arrangement of LLPS-promoting and solubilizing sequences in the genome lead to single genome packaging. Read on to learn about generalizable principles of virus compaction.
Biomacromolecules
Self-Assembly of Silk-like Protein into Nanoscale Bicontinuous Networks under Phase-Separation Conditions
Biomacromolecules
Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins
A Newfound Source of Cellular Order in the Chemistry of Life
Jan
27
Serena Sanulli on Chromatin and its Phases
Wednesday, January 27, 2021
Feb
24
Huaiying Zhang on Liquid-Liquid Phase Separation in Telomere Maintenance of ALT Cancer
Wednesday, February 24, 2021
Cells
Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome
Jill Bouchard
Contributing editor, Condensates.com
Do lipids make it into condensates? This method seeks to uncover the complicated relationship between lipids and many proteins that localize to condensates.
bioRxiv
Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains
Nature communications
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response
Jill Bouchard
Contributing editor, Condensates.com
Here's the 2nd paper that came out in the same day about p62 bodies. If you don't know much about them (no judging, I didn't either ;), these papers might help you get up to speed!
EMBO reports
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling
Jill Bouchard
Contributing editor, Condensates.com
Have you heard about p62 bodies yet? This is the first of two papers published on the same day about them.
Langmuir : the ACS journal of surfaces and colloids
Bulk Phase Behavior vs Interface Adsorption: Specific Multivalent Cation and Anion Effects on BSA Interactions
The journal of physical chemistry B
Structure-Function Properties in Disordered Condensates
Jill Bouchard
Contributing editor, Condensates.com
It was nice to get a sneak peak of this work from Jeremy Schmit at his Kitchen Table Talk in the fall. Check out Jeremy's video here for a great supplement to this paper!
Jan
14
Vanderbilt University Medical Center–Discovery Lecture Series: Michael Rosen
Thursday, January 14, 2021
Frontiers in cell and developmental biology
Complex Interactions Between Membrane-Bound Organelles, Biomolecular Condensates and the Cytoskeleton
Trends in cell biology
Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation
bioRxiv
Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate
Jill Bouchard
Contributing editor, Condensates.com
Cool, it looks like growing microtubules are regulated at least in part by the phase separation of plus-end tracking proteins (+TIPs).
bioRxiv