It's always fun to see the intersection of phase separation and membranes. Here a membrane protein oligomerizes and ultimately phase separates due to specific lipids.

bioRxiv

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

PLoS One

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Jill Bouchard

Contributing editor, Condensates.com

These authors investigated whether phase separation plays a role in aggregate formation. Check it out to find out their answer.

Kitchen Table Talk

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Rohit Pappu on Molecular Grammar of Condensates – Part 1

bioRxiv

Coupling between lipid miscibility and phosphotyrosine driven protein condensation at the membrane

Proceedings of the National Academy of Sciences of the United States of America

Differences in the free energies between the excited states of A β 40 and A β 42 monomers encode their aggregation propensities

Jill Bouchard

Contributing editor, Condensates.com

Using the population of excited states to empirically calculate the aggregation propensity could be a useful approach for predicting whether certain proteins will aggregate in condensates.

Phase Separation

Modulation of kinase activity within a bacterial membraneless organelle

Proteostasis Consortium: Jim Shorter

St Jude’s The Science of Childhood Cancer: Richard Kriwacki

Determinants for Fusion Speed of Biomolecular Droplets

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.

Equilibrium size distribution and phase separation of multivalent, molecular assemblies in dilute solution

Studying Protein Aggregation in the Context of Liquid-liquid Phase Separation Using Fluorescence and Atomic Force Microscopy, Fluorescence and Turbidity Assays, and FRAP

Rohit Pappu on Molecular Grammar of Condensates – Part 2

The emergence of phase separation as an organizing principle in bacteria

Molecular details of protein condensates probed by microsecond-long atomistic simulations

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

De novo engineering of intracellular condensates using artificial disordered proteins

The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis

Membraneless organelles: phasing out of equilibrium

The effects of phospholipids and fatty acids on the oligomer formation of NAP-22

Jill Bouchard

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Jill Bouchard

Rohit Pappu on Molecular Grammar of Condensates – Part 1

Coupling between lipid miscibility and phosphotyrosine driven protein condensation at the membrane

Differences in the free energies between the excited states of A β 40 and A β 42 monomers encode their aggregation propensities

Jill Bouchard

Laboratory Operations Assistant

Acquisition Specialist

Scientist/ Senior Scientist for Cell Applications & Assay Development (m/f/d)