PhD position in evaluation of liquid-liquid phase separation in disease cells and in vitro using fluorescence lifetime imaging and image correlation spectroscopy
The University of Manchester | Manchester, United Kingdom
ApplyMost Recent
bioRxiv
Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
BioRxiv
Mesoscale phase separation of chromatin in the nucleus
Cell death & disease
Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43
Cell
Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation
Science translational medicine
ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics
Jill Bouchard
Contributing editor, Condensates.com
This is quite a research study spanning all the way from patients to biophysical phase separation analysis. Check it out!
Proceedings of the National Academy of Sciences of the United States of America
Phase separation at the nanoscale quantified by dcFCCS
bioRxiv
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
bioRxiv
Widespread occurrence of the droplet state of proteins in the human proteome
bioRxiv
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Kitchen Table Talk
Must ReadJeremy Schmit on the Biophysical Basis of Condensate Functionality
Emerging topics in life sciences
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof
Jill Bouchard
Contributing editor, Condensates.com
I love the emphasis in this review that multivalency, not disorder, drives phase separation.
bioRxiv
Surface electrostatics govern the emulsion stability of biomolecular condensates
Jill Bouchard
Contributing editor, Condensates.com
Why don't all condensates (with the same properties) fuse together in cells? Here's a very thorough biophysical study at the forces that resist fusion.
Video
Video abstract: Protein Misfolding is Like a Box of Chocolates
Biophysical Journal
Liquid Phase Separation Controlled by pH
BioRxiv
Real-Time Observation of Structure and Dynamics during the Liquid-to-Solid Transition of FUS LC
The Journal of biological chemistry
Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: novel antiviral activity against VSV
Jill Bouchard
Contributing editor, Condensates.com
Check out how these proteins help resist viruses using phase separation!
Proceedings of the National Academy of Sciences of the United States of America
Liquid-liquid phase separation promotes animal desiccation tolerance
Cellular and molecular life sciences : CMLS
The structure and phase of tau: from monomer to amyloid filament
Viruses