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IDPSeminars: Keiji Numata & Julie Forman-Kay — June 10
Thursday, June 10, 2021
bioRxiv
Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
BioRxiv
TCAB1 is necessary for telomerase assembly
Jill Bouchard
Managing editor, Condensates.com
This is an interesting study about a protein that extracts components from the nucleolus so telomerase can assemble. I always love to hear when condensates play key roles in regulating important cellular functions.
Nature
A phase-separated nuclear GBPL circuit controls immunity in plants
bioRxiv
ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues
Science Translational Medicine
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain
Jill Bouchard
Managing editor, Condensates.com
Here's a way to get misplaced proteins out of condensates.
The Journal of biological chemistry
Droplet and fibril formation of the functional amyloid Orb2
GeroScience
Regulation of TDP-43 phosphorylation in aging and disease
Jill Bouchard
Managing editor, Condensates.com
This review covers what regulation means for TDP-43 localization and phase separation.
Nature chemical biology
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment
Nature Chemical Biology
A new phase for enzyme kinetics
Jill Bouchard
Managing editor, Condensates.com
Here's the News & Views article about the recent paper in Nat Chem Biol about enzymes and phase separation.
bioRxiv
Phase separation on cell surface: a mechanism of basic fibroblast growth factor signal transduction with heparan sulphate
bioRxiv
The mechanism underlying the organization of Borna disease virus inclusion bodies is unique among mononegaviruses
Protein science : a publication of the Protein Society
Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation
Nature communications
PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
bioRxiv
Transcription activation is enhanced by multivalent interactions independent of phase separation
Protein science : a publication of the Protein Society
FUS Oncofusion Protein Condensates Recruit mSWI/SNF Chromatin Remodeler via Heterotypic Interactions Between Prion-like Domains
Brain : a journal of neurology
Karyopherin abnormalities in neurodegenerative proteinopathies
Jill Bouchard
Managing editor, Condensates.com
This review focuses on the complex interplay between the dual functions of karyopherins--they're known for nuclear import/export, but they also act as chaperones of disease-related proteins that are prone to phase separate.
Briefings in bioinformatics
Proteome-scale analysis of phase-separated proteins in immunofluorescence images
Biophysical journal
Self-assembly of protein superstructures by physical interactions under cytoplasm-like conditions
Jill Bouchard
Managing editor, Condensates.com
Have you heard of gas vesicles? They are a protein droplet of sorts. Check out this paper to learn more.