Lab on a chip
Most Recent
Scientific reports
Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation
Molecular cell
A Prion-based Thermosensor in Plants
Jill Bouchard
Contributing editor, Condensates.com
Here's a commentary about a Nature article from earlier this year on the phase separation of a thermosensor in plants.
Nucleic acids research
PML nuclear bodies and chromatin dynamics: catch me if you can!
Biophysical journal
Coupled Membrane Lipid Miscibility and Phosphotyrosine-Driven Protein Condensation Phase Transitions
Jill Bouchard
Contributing editor, Condensates.com
Cool--protein droplets on membranes cause lipids to phase separate too!
Biochemistry Biokhimiia
Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis
Jill Bouchard
Contributing editor, Condensates.com
Do you have a protein that may or may not form aggregates in membraneless organelles? This paper might serve as a nice resource to compare all known instances of potential amyloid formation.
Experimental & molecular medicine
The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
Jill Bouchard
Contributing editor, Condensates.com
This review briefly mentions how phase separation plays a role in TDP-43's prion-like propagation.
Cell reports
Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging
Nature communications
Active coacervate droplets as a model for membraneless organelles and protocells
Molecular plant
Unraveling the 3D Genome Architecture in Plants: Present and Future
Jill Bouchard
Contributing editor, Condensates.com
It's not surprising to me that this review discusses phase separation as part of the current knowledge about chromatin organization in plants. Check it out to find out more.
Journal of molecular biology
Hofmeister Ions Modulate the Autocatalytic Amyloidogenesis of an Intrinsically Disordered Functional Amyloid Domain via Unusual Biphasic Kinetics
Current opinion in structural biology
How do intrinsically disordered protein regions encode a driving force for liquid-liquid phase separation?
Nov
03
Johns Hopkins Chemistry Seminars–Fibrillization and Liquid-Liquid Phase Separation of the Tau Peptide
Tuesday, November 3, 2020
Chem Systems Chem
Accelerated Ripening in Chemically Fueled Emulsions
Jill Bouchard
Contributing editor, Condensates.com
Here's a synthetic system to replicate membraneless organelles and test theories for how droplets ripen.
bioRxiv
Coordination of RNA and protein condensation by the P granule protein MEG-3
BioRxiv
Mechanisms of scaffold-mediated microcompartment assembly and size-control
Jill Bouchard
Contributing editor, Condensates.com
I'm a big fan of the scaffold-client theory about condensates. Here's an extension to that theory that explains how they regulate the size of condensates.
Jan
27
Biomolecular Condensates in Cancer
Thursday, January 27, 2022 | Pacific Grove, CA, United States
bioRxiv
Charge-Driven Condensation of RNA and Proteins Suggests Broad Role of Phase Separation in Cytoplasmic Environments
Developmental Cell
Phase Separation-A Physical Mechanism for Organizing Information and Biochemical Reactions
Jill Bouchard
Contributing editor, Condensates.com
Our good friend Rohit Pappu wrote a nice commentary introducing a series of reviews on phase separation in the latest issue of Developmental Cell. Check out each of the 7 below: 1) Phase Separation in Germ Cells and Development 2) LLPS in neuronal development and synaptic signaling 3) Phase Separation in Membrane Biology 4) Phase Separation and Neurodegenerative Diseases 5) Emerging Roles for Phase Sseparation in Plants 6) Biomolecular Condensates and Gene Activation in Development and Disease 7) Visualizing Molecular Architectures of Cellular Condensates
Developmental cell