Current opinion in cell biology
Most Recent
Journal of molecular cell biology
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Journal of molecular biology
Biochemical timekeeping via reentrant phase transitions
BioRxiv
Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates
bioRxiv
Multivalent polymers can control phase boundary, dynamics, and organization of liquid-liquid phase separation
Analytical Chemistry
Monitoring the Dynamics of Proteome Aggregation in Live Cells Using a Solubilized and Noncovalent Analogue of Fluorescent Protein Chromophores
Jill Bouchard
Contributing editor, Condensates.com
Cool! This new sensor can detect liquid-to-solid transitions with 2 different colors.
Journal of the American Chemical Society
Effects of Glutamate Arginylation on α-Synuclein: Studying an Unusual Post-Translational Modification through Semisynthesis
Jill Bouchard
Contributing editor, Condensates.com
I could see this being an effective strategy to interrogate the effects of unusual PTMs on proteins involved in LLPS too.
The journal of physical chemistry B
Liquid-Liquid Phase Separation of Peptide/Oligonucleotide Complexes in Crowded Macromolecular Media
BioRxiv
Hsp70 chaperons TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation
bioRxiv
Oxidized RNA Bodies compartmentalize translation quality control in Saccharomyces cerevisiae
Jill Bouchard
Contributing editor, Condensates.com
Here's an update to the paper about the new condensate (ORBs) that communicate with stress granules and P bodies.
BioRxiv
Amyloid fibril-based hydrogels for high-throughput tumor spheroid modeling
bioRxiv
Solubility product constant directs the formation of biomolecular condensates
bioRxiv
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells
ACS central science
Formation of Biomolecular Condensates in Bacteria by Tuning Protein Electrostatics
The journal of physical chemistry letters
Amyloid Aggregation under the Lens of Liquid-Liquid Phase Separation
Cell
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations
bioRxiv
The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
Jill Bouchard
Contributing editor, Condensates.com
I like that the authors discuss what their results mean in the context of all the recent reports that the N protein phase separates.
International journal of molecular sciences
Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications
ACS Nano
Genome-in-a-Box: Building a Chromosome from the Bottom Up
bioRxiv