Developmental cell
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Developmental cell
Biomolecular Condensates and Gene Activation in Development and Disease
Developmental cell
Visualizing Molecular Architectures of Cellular Condensates: Hints of Complex Coacervation Scenarios
Emerging topics in life sciences
Drops and fibers – how biomolecular condensates and cytoskeletal filaments influence each other
PLoS computational biology
Protein-protein interactions in neurodegenerative diseases: A conspiracy theory
Jill Bouchard
Contributing editor, Condensates.com
Even if you're also tired of seeing political conspiracy theories these days, this is a phase-separation-based-conspiracy theory that is worth thinking about.
Nucleic Acids Research
Mechanism of efficient double-strand break repair by a long non-coding RNA
Jill Bouchard
Contributing editor, Condensates.com
What doesn't phase separation do?! These authors show it has a role in repairing lncRNA too.
BioRxiv
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2
bioRxiv
Simulation of FUS protein condensates with an adapted coarse-grained model
Chemical communications (Cambridge, England)
Translation-coupled RNA replication and parasitic replicators in membrane-free compartments
Angewandte Chemie (International ed in English)
Disease-associated tau phosphorylation hinders tubulin assembly within tau condensates
Proceedings of the National Academy of Sciences of the United States of America
Phase separation by ssDNA binding protein controlled via protein-protein and protein-DNA interactions
Molecular biology and evolution
Natural selection on the phase-separation properties of FUS during 160 million years of mammalian evolution
Molecular reproduction and development
SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice biophysical analysis of the phase separation of a couple proteins involved in transcription.
Biochimica et biophysica acta Gene regulatory mechanisms
From start to end: phase separation and transcriptional regulation
Trends in genetics : TIG
DNA Damage Triggers a New Phase in Neurodegeneration
bioRxiv
TopBP1 assembles nuclear condensates to switch on ATR signalling.
bioRxiv
Force-dependent remodeling of a tight junction protein ZO-1 is regulated by phase separation
Jill Bouchard
Contributing editor, Condensates.com
I love seeing how phase separation is involved in so many cellular processes... and now I can add cell adhesion in early development to the list.
Nov
03
The 26th Advanced School in Life Sciences (ZOOM event)–Condensates and Phase Separation in Biology
Tuesday, November 3, 2020
Science
Beyond aggregation: Pathological phase transitions in neurodegenerative disease
Jill Bouchard
Contributing editor, Condensates.com
Have you seen this review yet? I think it's gonna be a great one!
Biochimica et biophysica acta Molecular cell research