bioRxiv
Most Recent
Soft Matter
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method
Cell Reports
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
ACS nano
Real-Time Study of Protein Phase Separation with Spatiotemporal Analysis of Single-Nanoparticle Trajectories
Journal of neurochemistry
The multi-functional RNA binding protein G3BP1 and its potential implication in neurodegenerative disease
Jill Bouchard
Contributing editor, Condensates.com
This review covers G3BP1's role in phase separation and the formation of stress granules in looking for clues for how to target it therapeutically.
The EMBO journal
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration
bioRxiv
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
bioRxiv
Rotavirus Replication Factories Are Complex Ribonucleoprotein Condensates
Nucleic acids research
Splicing at the phase-separated nuclear speckle interface: a model
The Journal of biological chemistry
Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo
Jill Bouchard
Contributing editor, Condensates.com
This essential transcription factor phase separates and its IDR is responsible for its localization to nucleoli.
The FEBS journal
Structure and function of p62/SQSTM1 in the emerging framework of phase separation
Science
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
Cell Proliferation
Super enhancers-Functional cores under the 3D genome
Biophysical chemistry
The role of water in the primary nucleation of protein amyloid aggregation
Jill Bouchard
Contributing editor, Condensates.com
And this role is different inside and at the interface of condensates. Read on to find out which condition facilitates quicker aggregation.
Frontiers in molecular neuroscience
New Insights Into Drug Discovery Targeting Tau Protein
Jill Bouchard
Contributing editor, Condensates.com
I like that this review addresses the role LLPS plays in tau aggregation and targeting it therapeutically.
Open biology
The role of disorder in RNA binding affinity and specificity
Frontiers in Neuroscience
Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins
Jill Bouchard
Contributing editor, Condensates.com
Most of the proteins this review covers also undergo LLPS, so the authors discuss the interactions that lead to both solid and liquid phases too.
Frontiers in Molecular Neuroscience
MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments
Jill Bouchard
Contributing editor, Condensates.com
This review seeks to provide a roadmap for studying phase separation (mostly for solids and also a little about liquids). It seems to house a wealth of information.
Communications biology
Biomolecular condensates as arbiters of biochemical reactions inside the nucleus
Cell reports
Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore
Jill Bouchard
Contributing editor, Condensates.com
Based on their results, the authors propose a "model of proximal control of phase separation." Check out the full paper for the details.