Here's a nice review on the biophysical properties of stress granules and paraspeckles in the hopes of finding a condensate-based therapy for neuodegenerative disorders.

bioRxiv

Molecular details of protein condensates probed by microsecond-long atomistic simulations

bioRxiv

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Must Read

Nature chemistry

De novo engineering of intracellular condensates using artificial disordered proteins

Emerging topics in life sciences

Membraneless organelles: phasing out of equilibrium

Neuroscience letters

The effects of phospholipids and fatty acids on the oligomer formation of NAP-22

Jill Bouchard

Contributing editor, Condensates.com

It's always fun to see the intersection of phase separation and membranes. Here a membrane protein oligomerizes and ultimately phase separates due to specific lipids.

bioRxiv

Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation

bioRxiv

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

PLoS One

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Jill Bouchard

Contributing editor, Condensates.com

These authors investigated whether phase separation plays a role in aggregate formation. Check it out to find out their answer.

Kitchen Table Talk

Must Read

Rohit Pappu on Molecular Grammar of Condensates – Part 1

bioRxiv

Physics of Condensates

Modulation of kinase activity within a bacterial membraneless organelle

St Jude’s The Science of Childhood Cancer: Richard Kriwacki

Determinants for Fusion Speed of Biomolecular Droplets

Multivalent interactions between eIF4G1, Pub1 and Pab1 drive the formation of protein condensates

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress.

Equilibrium size distribution and phase separation of multivalent, molecular assemblies in dilute solution

Studying Protein Aggregation in the Context of Liquid-liquid Phase Separation Using Fluorescence and Atomic Force Microscopy, Fluorescence and Turbidity Assays, and FRAP

Rohit Pappu on Molecular Grammar of Condensates – Part 2

The emergence of phase separation as an organizing principle in bacteria

Pathophysiological Implications of RNP Granules in Frontotemporal Dementia and ALS

Jill Bouchard

Molecular details of protein condensates probed by microsecond-long atomistic simulations

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

De novo engineering of intracellular condensates using artificial disordered proteins

Membraneless organelles: phasing out of equilibrium

The effects of phospholipids and fatty acids on the oligomer formation of NAP-22

Jill Bouchard

Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Jill Bouchard

Rohit Pappu on Molecular Grammar of Condensates – Part 1

Coupling between lipid miscibility and phosphotyrosine driven protein condensation at the membrane

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