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10
IDPSeminars: Keiji Numata & Julie Forman-Kay — June 10
Thursday, June 10, 2021
bioRxiv
Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
BioRxiv
TCAB1 is necessary for telomerase assembly
Jill Bouchard
Managing editor, Condensates.com
This is an interesting study about a protein that extracts components from the nucleolus so telomerase can assemble. I always love to hear when condensates play key roles in regulating important cellular functions.
Nature
A phase-separated nuclear GBPL circuit controls immunity in plants
bioRxiv
ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues
The Journal of biological chemistry
Droplet and fibril formation of the functional amyloid Orb2
Nature chemical biology
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment
Nature Chemical Biology
A new phase for enzyme kinetics
Jill Bouchard
Managing editor, Condensates.com
Here's the News & Views article about the recent paper in Nat Chem Biol about enzymes and phase separation.
bioRxiv
Phase separation on cell surface: a mechanism of basic fibroblast growth factor signal transduction with heparan sulphate
bioRxiv
The mechanism underlying the organization of Borna disease virus inclusion bodies is unique among mononegaviruses
Protein science : a publication of the Protein Society
Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation
Nature communications
PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
bioRxiv
Transcription activation is enhanced by multivalent interactions independent of phase separation
Protein science : a publication of the Protein Society
FUS Oncofusion Protein Condensates Recruit mSWI/SNF Chromatin Remodeler via Heterotypic Interactions Between Prion-like Domains
Biophysical journal
Self-assembly of protein superstructures by physical interactions under cytoplasm-like conditions
Jill Bouchard
Managing editor, Condensates.com
Have you heard of gas vesicles? They are a protein droplet of sorts. Check out this paper to learn more.
Cell stem cell
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
Neuron
Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation
BioRxiv
Sustained Enzymatic Activity and Flow in Crowded Protein Droplets
Elife