Multiple positions in the Lab for Synthetic Macromolecular Assemblies
George Lu Lab @ Rice University | Houston, TX
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bioRxiv
Remnants of the Balbiani body are required for formation of RNA transport granules in Xenopus oocytes
Target ID/Interactome Mapping-Group Leader PhD
Dewpoint Therapeutics | Boston, MA USA
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Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells
Jill Bouchard
Contributing editor, Condensates.com
It looks like dengue viral capsid phase separates and joins the nucleolus as part of it's invasion strategy... another way (of the many) that viruses use our condensates against us.
Current opinion in cell biology
Karyopherins and Condensates
Trends in biochemical sciences
Mechanisms and Regulation of RNA Condensation in RNP Granule Formation
The Journal of Biological Chemistry
Phase-separated Condensate-Aided Enrichment of Biomolecular Interactions for High-Throughput Drug Screening in Test Tubes
Molecular Cell
Sequence-Independent Self-Assembly of Germ Granule mRNAs Into Homotypic Clusters
Journal of molecular cell biology
The Protective Role of m1A During Stress-Induced Granulation
Jill Bouchard
Contributing editor, Condensates.com
Here's the second article this week showing a role of mRNA methylation in condensate formation... only this time it's m1A (where the N1 A gets post-transcriptionally modified).
The FEBS journal
The More the Merrier: Effects of Macromolecular Crowding on the Structure and Dynamics of Biological Membranes
Jill Bouchard
Contributing editor, Condensates.com
This review covers 2 types of condensates lipid-droplets and protein-phase separation at and near membranes. Check it out if you'd like to learn about the latest developments.
bioRxiv
A selective autophagy pathway for phase separated endocytic protein deposits
Nature chemical biology
M 6 A-binding YTHDF Proteins Promote Stress Granule Formation
Jill Bouchard
Contributing editor, Condensates.com
ICYMI m6A is methylated mRNA (on the N6 of the adenine), so post-transcriptional modifications play a role in condensate formation just as much as post-translational ones.
Small (Weinheim an der Bergstrasse, Germany)
Invasion and Defense Interactions Between Enzyme-Active Liquid Coacervate Protocells and Living Cells
Chemistry (Weinheim an der Bergstrasse, Germany)
Alteration of the Conformational Dynamics of a DNA Hairpin by α-Synuclein in the Presence of Aqueous Two-Phase Systems
Jill Bouchard
Contributing editor, Condensates.com
This study applies pressure to a phase-separated neuro-protein interacting with DNA to understand how the DNA is altered long-term.
BioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
BioRxiv
The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form
Jill Bouchard
Contributing editor, Condensates.com
Interesting... these authors show reversible hydrogels contain amyloid-like fibrils.
BioRxiv
Membrane bending by protein phase separation
Cells
Protein Phase Separation During Stress Adaptation and Cellular Memory
Trends in biochemical sciences
Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria
bioRxiv