bioRxiv
Most Recent
Journal of molecular cell biology
Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies
Journal of molecular biology
Biochemical timekeeping via reentrant phase transitions
PloS one
Assessing the low complexity of protein sequences via the low complexity triangle
Jill Bouchard
Contributing editor, Condensates.com
Do you need a new angle to look at an IDP or LCD to understand why it behaves a certain way in a condensate? Maybe this method will help.
BioRxiv
Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates
bioRxiv
Multivalent polymers can control phase boundary, dynamics, and organization of liquid-liquid phase separation
The journal of physical chemistry B
Conformational Preferences of an Intrinsically Disordered Protein Domain: A Case Study for Modern Force Fields
Jill Bouchard
Contributing editor, Condensates.com
If you're on the market to find the best way to simulate a phase separating IDP, this should be a good resource.
Analytical Chemistry
Monitoring the Dynamics of Proteome Aggregation in Live Cells Using a Solubilized and Noncovalent Analogue of Fluorescent Protein Chromophores
Jill Bouchard
Contributing editor, Condensates.com
Cool! This new sensor can detect liquid-to-solid transitions with 2 different colors.
The journal of physical chemistry B
Liquid-Liquid Phase Separation of Peptide/Oligonucleotide Complexes in Crowded Macromolecular Media
BioRxiv
Hsp70 chaperons TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation
bioRxiv
PARprolink: a photoaffinity probe for identifying poly(ADP-ribose)-binding proteins
Jill Bouchard
Contributing editor, Condensates.com
Not only did these authors develop a new method to identify PAR-binding proteins, they also found them to be enriched in condensates. Read further to find out which ones.
bioRxiv
Solubility product constant directs the formation of biomolecular condensates
ACS nano
Tunable Electromechanical Nanopore Trap Reveals Populations of Peripheral Membrane Protein Binding Conformations
Jill Bouchard
Contributing editor, Condensates.com
I wonder if this this nanopore could be used to investigate proteins involved in membrane-associated condensates too?
ACS central science
Formation of Biomolecular Condensates in Bacteria by Tuning Protein Electrostatics
The journal of physical chemistry letters
Amyloid Aggregation under the Lens of Liquid-Liquid Phase Separation
Cell
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations
STAR protocols
Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation
Cell chemical biology
Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor
Jill Bouchard
Contributing editor, Condensates.com
The main inhibitor they found also increases the formation of P bodies.
International journal of molecular sciences
Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications
ACS Nano