bioRxiv
Most Recent
bioRxiv
Connecting coil-to-globule transitions to full phase diagrams for intrinsically disordered proteins
BioRxiv
Chromatin folding variability across single-cells results from state degeneracy in phase-separation
Biophysical reviews
RNA Phase Separation-Mediated Direction of Molecular Trafficking Under Conditions of Molecular Crowding
Proceedings of the National Academy of Sciences of the United States of America
Liquid-liquid Phase Separation of Type II Diabetes-Associated IAPP Initiates Hydrogelation and Aggregation
Jill Bouchard
Contributing editor, Condensates.com
Here's another study suggesting condensates initiate amyloid formation, except this is in the context of type II diabetes.
bioRxiv
Structure−function properties in disordered condensates
Jill Bouchard
Contributing editor, Condensates.com
It's interesting to see how the structures outside and inside condensates matter for function.
bioRxiv
Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation
Journal of autoimmunity
Proteins in Assemblages Formed by Phase Separation Possess Properties That Promote Their Transformation to Autoantigens: Implications for Autoimmunity
Physical review E
Active Suppression of Ostwald Ripening: Beyond Mean-Field Theory
Jill Bouchard
Contributing editor, Condensates.com
Do you ever wonder why all the condensates in cells don't fuse into one big one? This review discusses the different physical forces at play.
BioRxiv
The Proline-rich Domain Promotes Tau Liquid Liquid Phase Separation in Cells
bioRxiv
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
Jill Bouchard
Contributing editor, Condensates.com
I love how phase separation has its hands in membrane curvature.
Nature
Composition-dependent Thermodynamics of Intracellular Phase Separation
bioRxiv
Phe-Gly Motifs Drive Fibrillization of TDP-43’s Prion-Like Domain Droplets
Jill Bouchard
Contributing editor, Condensates.com
I find it very interesting that the outer edges of droplets nucleated fibrils.
DNA and cell biology
DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells
Proceedings of the National Academy of Sciences of the United States of America
Identifying Sequence Perturbations to an Intrinsically Disordered Protein That Determine Its Phase-Separation Behavior
Biomolecules
Targeting Intrinsically Disordered Proteins Through Dynamic Interactions
Jill Bouchard
Contributing editor, Condensates.com
The advancements made for targeting IDPs will most certainly carry over to condensates.
bioRxiv
Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly
Kitchen Table Talk
Amy Gladfelter on RNA-Driven Phase Separation
bioRxiv
L-bodies are novel RNA-protein condensates driving RNA transport in Xenopus oocytes
Jill Bouchard
Contributing editor, Condensates.com
Meet the newest condensate: L-bodies -- multiphase RNP granules that carry maternal mRNA to oocytes
bioRxiv
Mitochondrial cytochrome c liberates the nucleophosmin-sequestered ARF tumor suppressor in the nucleolus
Jill Bouchard
Contributing editor, Condensates.com
This paper shows an interesting cross-talk between the mitochondria and nucleolus upon DNA damage.