Developmental cell
Most Recent
Developmental cell
Visualizing Molecular Architectures of Cellular Condensates: Hints of Complex Coacervation Scenarios
Emerging topics in life sciences
Drops and fibers – how biomolecular condensates and cytoskeletal filaments influence each other
PLoS computational biology
Protein-protein interactions in neurodegenerative diseases: A conspiracy theory
Jill Bouchard
Contributing editor, Condensates.com
Even if you're also tired of seeing political conspiracy theories these days, this is a phase-separation-based-conspiracy theory that is worth thinking about.
BioRxiv
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2
bioRxiv
In Vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)
Jill Bouchard
Contributing editor, Condensates.com
Here's a study where researchers applied a new method to follow FUS and TDP-43 localization in live cells. Looks to be pretty useful for condensate studies!
bioRxiv
Simulation of FUS protein condensates with an adapted coarse-grained model
Chemical communications (Cambridge, England)
Translation-coupled RNA replication and parasitic replicators in membrane-free compartments
Oct
15
IDPSeminars: Benedetta Bolognesi & Sarah Shammas — Oct 15
Thursday, October 15, 2020
Biochimica et biophysica acta Molecular cell research
A prion-like domain of Tpk2 catalytic subunit of protein kinase A modulates P-body formation in response to stress in budding yeast
bioRxiv
Clustering-based positive feedback between a kinase and its substrate enables effective T-cell receptor signaling
Jill Bouchard
Contributing editor, Condensates.com
Here's a new optogenetic method to induce condensates. And the authors show they have a specific role in signalling cascades.
Proceedings of the National Academy of Sciences of the United States of America
An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase
Jill Bouchard
Contributing editor, Condensates.com
Here's a thorough biophysical analysis of an IDP involved in membrane remodeling. I bet the methods would also be useful to study condensate-mediated membrane bending.
BioRxiv
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Angewandte Chemie (International ed in English)
Disease-associated tau phosphorylation hinders tubulin assembly within tau condensates
Current protocols in bioinformatics
Exploring Manually Curated Annotations of Intrinsically Disordered Proteins with DisProt
Jill Bouchard
Contributing editor, Condensates.com
I bet that being able to explore manually curated annotations will really help answer complex questions about IDPs.
Proceedings of the National Academy of Sciences of the United States of America
Phase separation by ssDNA binding protein controlled via protein-protein and protein-DNA interactions
Molecular biology and evolution
Natural selection on the phase-separation properties of FUS during 160 million years of mammalian evolution
Molecular reproduction and development
SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice biophysical analysis of the phase separation of a couple proteins involved in transcription.
Biochimica et biophysica acta Gene regulatory mechanisms
From start to end: phase separation and transcriptional regulation
Trends in genetics : TIG