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Nature

Formin-mediated nuclear actin at androgen receptors promotes transcription

Robert Grosse

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We found that highly dynamic nuclear actin polymerisation drives the formation of bimolecular condensates at androgen receptors in response to androgen signalling. Thus, nuclear actin assembly may contribute to condensate formation and nuclear organisation in cellulo. Furthermore, the actin nucleator DAAM2 mediates this process and is mutated in patients with PAIS.