BioRxiv
Most Recent
bioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
BioRxiv
Nuclear phosphatidylinositol 3,4,5-trisphosphate interactome uncovers an enrichment in nucleolar proteins
Jill Bouchard
Contributing editor, Condensates.com
It's cool to see important lipid signaling molecules show up in condensates!
Molecular biology of the cell
Synergistic Interactions Between Cajal Bodies and the miRNA Processing Machinery
Nature Methods
Cell Biology Befriends Soft Matter Physics
Scientific reports
Comparative Analysis of MACROD1, MACROD2 and TARG1 Expression, Localisation and Interactome
Jill Bouchard
Contributing editor, Condensates.com
These proteins appear to be important regulators of nucleoli and stress granules.
bioRxiv
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
bioRxiv
Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation
bioRxiv
Stress granules display bistable dynamics modulated by Cdk
Jill Bouchard
Contributing editor, Condensates.com
Perhaps this modulation of stress granules will be therapeutically relevant for figuring out how to dissolve them.
Kitchen Table Talk
Amy Gladfelter on RNA-Driven Phase Separation
Scientific Reports
Super-resolution in Situ Analysis of Active Ribosomal DNA Chromatin Organization in the Nucleolus
Jill Bouchard
Contributing editor, Condensates.com
The architecture of nucleoli is fascinating, and we'll get so many more insights into how they work as more awesome methods like this come out.
Kitchen Table Talk
Liam Holt on Crowding and Compression
Cell
Unblending of Transcriptional Condensates in Human Repeat Expansion Disease
Jill Bouchard
Contributing editor, Condensates.com
It's not surprising that repeat expansions alter the phase separation and subsequent material properties of condensates. The discussion on how poly-alanine (and other IDR) tracts contribute to disease will be super useful going forward.
Traffic (Copenhagen, Denmark)
Regulation of RNA Granules by FMRP and Implications for Neurological Diseases
mBio
Conserved Outer Tegument Component UL11 From Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein
Jill Bouchard
Contributing editor, Condensates.com
They forgot to mention "that phase separates" at the end of the title ;)
The Plant journal : for cell and molecular biology
Core Spliceosomal Sm Proteins as Constituents of Cytoplasmic mRNPs in Plants
Jill Bouchard
Contributing editor, Condensates.com
We know quite a bit about how condensates are involved in post-translational modifications for mammals. This work seeks to find out how plants compare.
Annals of clinical and translational neurology
VRK1 (Y213H) Homozygous Mutant Impairs Cajal Bodies in a Hereditary Case of Distal Motor Neuropathy
Brain : a journal of neurology
In Vivo Stress Granule Misprocessing Evidenced in a FUS Knock-In ALS Mouse Model
Molecular cell
Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies Through DNMT3A Exclusion
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting new method to look at genome regions and their relation to condensates.
Theranostics
Discrete Functional and Mechanistic Roles of Chromodomain Y-like 2 (CDYL2) Transcript Variants in Breast Cancer Growth and Metastasis
Jill Bouchard
Contributing editor, Condensates.com
It looks like certain isoforms of the CDYL2 protein stick to condensates in breast cancer cells affecting proliferation, migration and invasion.