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Mar
11
IDPSIG and friends Virtual Symposium
Thursday, March 11, 2021
bioRxiv
Slow chromatin dynamics enhances promoter accessibility to transcriptional condensates
Jill Bouchard
Contributing editor, Condensates.com
This is a nice example of how polymer physics comes in handy for describing condensates.
bioRxiv
Pak1 kinase regulates ribonucleoprotein granules through Sts5 for polarized growth and the glucose starvation response
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting study showing the effects of phosphorylation on an IDP's ability to localize with P bodies.
bioRxiv
The cohesin regulator Stag1 promotes cell plasticity through heterochromatin regulation
Jill Bouchard
Contributing editor, Condensates.com
It looks like this paper has identified a new regulator of certain condensates, with big implications for disease too.
The FEBS journal
Aberrant phase separation and cancer
Biophysical journal
Phase Separation of DNA: From Past to Present
Proteins
Thermodynamic stability of hnRNP A1 low complexity domain revealed by high-pressure NMR
Proceedings of the National Academy of Sciences of the United States of America
Local translation in nuclear condensate amyloid bodies
Nature Biotechnology
Drug startups coalesce around condensates
Genome biology
3 ‘-5 ‘ crosstalk contributes to transcriptional bursting
Jill Bouchard
Contributing editor, Condensates.com
This paper applies Bayesian modeling to understand transcriptional bursting happening in condensates.
Protein science : a publication of the Protein Society
N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein FUS
BioRxiv
New lessons on TDP-43 from the killifish N. furzeri
Jill Bouchard
Contributing editor, Condensates.com
Do you need a good animal model to study TDP-43 phase separation? This paper says the killifish might be a good option.
Molecular cell
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
Frontiers in cell and developmental biology
Stress Granules in the Post-transcriptional Regulation of Immune Cells
Jill Bouchard
Contributing editor, Condensates.com
There could be some important insights about stress granules in this review if you're looking into targeting them therapeutically.
Molecular cell
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
BioRxiv
RNA polymerase II clusters form in line with liquid phase wetting of chromatin
Kitchen Table Talk
Must ReadSerena Sanulli on Chromatin and its Phases
bioRxiv
piRNAs Coordinate poly(UG) Tailing to Prevent Aberrant and Permanent Gene Silencing
Jill Bouchard
Contributing editor, Condensates.com
The authors put forth a couple of models about how condensates are involved in this new function of piRNAs. Check them out in the discussion.
Nature reviews Molecular cell biology