Sep
15
Broder Schmidt on Targeting Intrinsically Disordered Proteins (IDPs): In the Pack vs. the Lone Wolf
Wednesday, September 15, 2021
Most Recent
bioRxiv
Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA
Proceedings of the National Academy of Sciences of the United States of America
Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation
Nature communications
High-depth spatial transcriptome analysis by photo-isolation chemistry
Jill Bouchard
Managing editor, Condensates.com
This looks to be a useful new method to detect genes expressed in condensates.
Journal of molecular biology
Interplay between disordered regions in RNAs and proteins modulates interactions within stress granules and processing bodies
Journal of molecular biology
Nuclear protein condensates and their properties in regulation of gene expression
Biomacromolecules
Phase Separation and Protein Partitioning in Compartmentalized Cell-Free Expression Reactions
bioRxiv
Imaging and single cell sequencing analyses of super-enhancer activation mediated by NF-κB in B cells
RNA (New York, NY)
Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules
bioRxiv
Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington disease progression
The FEBS journal
Nuclear speckles: dynamic hubs of gene expression regulation
Nucleic Acids Research
Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases
Jill Bouchard
Managing editor, Condensates.com
This review is full of a lot of juicy details about the role of RNA in phase separation.
Nature Reviews Genetics
Oncogenesis by phase separation
Jill Bouchard
Managing editor, Condensates.com
Here's the Research Highlight about the about the recent Nature paper on the role of phase separation in chromatin looping and cancer
the Journal of Chemical Physics
Multiscale modeling of genome organization with maximum entropy optimization
Jill Bouchard
Managing editor, Condensates.com
In-cell experiments to answer questions about genome organization are tricky. Computational modeling can help. See what it has to say about the role of phase separation.
PLoS pathogens
The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury
Jill Bouchard
Managing editor, Condensates.com
Here's yet another viral protein (a ds-RBP) that affects stress granules in order to evade the immune response.
bioRxiv
Force generation by protein-DNA co-condensation
Cell
Interconnecting solvent quality, transcription, and chromosome folding in Escherichia coli
Nature
A condensate-hardening drug blocks RSV replication in vivo
Bio Systems
Removing quote marks from the RNA polymerase II CTD ‘code’
Jill Bouchard
Managing editor, Condensates.com
How does phase separation change what we know about the Pol II CTD code? Read this review to find out.
International journal of molecular sciences
Drosophila to Explore Nucleolar Stress
Jill Bouchard
Managing editor, Condensates.com
This paper delves into a whole lot of condensate crosstalk.