Nucleic acids research
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Cell reports
Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging
Jan
27
Biomolecular Condensates in Cancer
Thursday, January 27, 2022 | Pacific Grove, CA, United States
Developmental cell
Biomolecular Condensates and Gene Activation in Development and Disease
Oct
15
IDPSeminars: Benedetta Bolognesi & Sarah Shammas — Oct 15
Thursday, October 15, 2020
BioRxiv
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Molecular reproduction and development
SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice biophysical analysis of the phase separation of a couple proteins involved in transcription.
Biochimica et biophysica acta Gene regulatory mechanisms
From start to end: phase separation and transcriptional regulation
Plants (Basel, Switzerland)
Overexpression of OsC3H10, a CCCH-Zinc Finger, Improves Drought Tolerance in Rice by Regulating Stress-Related Genes
Jill Bouchard
Contributing editor, Condensates.com
It's not surprising to me that this protein regulates stress and also localizes to stress granules. Should I be surprised about its localization to P bodies though?
International journal of molecular sciences
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA
Cell reports
Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
Jill Bouchard
Contributing editor, Condensates.com
It looks like nuclear speckles play a pretty big role in HIV viral infection.
Molecular neurobiology
Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases
Jill Bouchard
Contributing editor, Condensates.com
Phase separation gets a quick shout out in this review--for being part of how hnRNP proteins may regulate stress granule formation and be involved in ALS.
International journal of molecular sciences
The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration
Jill Bouchard
Contributing editor, Condensates.com
This review also mentions how phase separation is involved.
bioRxiv
Surface condensation of a pioneer transcription factor on DNA
World journal of gastroenterology
Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications
Archives of biochemistry and biophysics
Deciphering piRNA biogenesis through cytoplasmic granules, mitochondria and exosomes
Jill Bouchard
Contributing editor, Condensates.com
This review covers how various condensates play a role in the lifespan of RNAs that are important for "germ-line integrity."
Nucleic acids research
Periphilin self-association underpins epigenetic silencing by the HUSH complex
Jill Bouchard
Contributing editor, Condensates.com
All the common features of phase separation (intrinsic disorder, dimerization, and Arg/Tyr low complexity) contribute to fibril and condensate formation here.
bioRxiv
Capillary forces drive pioneer transcription factor-mediated DNA condensation
FEBS open bio
Dissecting the transactivation domain (tAD) of the transcription factor c-Myb to assess recent models of tAD function
Jill Bouchard
Contributing editor, Condensates.com
Here's a nice study testing the contribution of Short LInear Motif (SLIM) exposure vs LLPS. Intriguingly, the authors found SLIMs dominate in 2 mammalian systems, yet LLPS dominated in yeast.
PhD student
Wageningen University | Wageningen, Netherlands
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