Most Recent
Experimental Eye Research
Managing editor, Condensates.com
This could be quite an interesting review: it connects phase separation and transcriptional regulation during eye development and disease progression.
bioRxiv
bioRxiv
Current opinion in microbiology
Molecular Cell
Nature communications
Managing editor, Condensates.com
These "fuzzy" interactions seem to be suggesting that condensation is involved here. I'm glad the authors discussed this possibility at the end of the paper.
bioRxiv
The Journal of biological chemistry
Managing editor, Condensates.com
It looks like a bunch of nuclear import receptors (or importins and exportins or karyopherins... whatever you want to call them) can bind FUS and weaken its LLPS propensity and reduce its localization to stress granules.
Nucleic acids research
Thursday, April 15, 2021
Frontiers in cellular neuroscience
Managing editor, Condensates.com
This paper offers some perspective on the effects of Arg methylation on LLPS and localization of RNA-binding proteins in neurodegenerative diseases.
Monday, May 17, 2021
Wednesday, May 26, 2021
Journal of Molecular Cell Biology
Molecular cell
Molecular Biology of the Cell
International journal of molecular sciences
International journal of molecular sciences
International journal of molecular sciences
Managing editor, Condensates.com
I like that these authors analyzed both intrinsic disorder and LLPS propensity of proteins with disease mutations. Check out their results!
International journal of molecular sciences
Managing editor, Condensates.com
Here's a nice review about the role of mutations in RNA-binding proteins that causes dysfunction of various membraneless organelles.