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The international journal of biochemistry & cell biology
“STRESSED OUT”: The Role of FUS and TDP-43 in Amyotrophic lateral sclerosis
Jill Bouchard
Contributing editor, Condensates.com
Understanding how these proteins gain cytoplasmic functions and lose nuclear functions may help us figure out how to target condensates to restore balance.
Trends in genetics : TIG
Search and Capture: Disorder Rules Gene Promoter Selection
Jill Bouchard
Contributing editor, Condensates.com
Here's the spotlight article for the recent Mol Cell paper about IDPs and in vivo binding specificity.
Journal of visualized experiments : JoVE
Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images
Jill Bouchard
Contributing editor, Condensates.com
This could be a really helpful method to monitor condensates.
Nature microbiology
Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements
Nature cell biology
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis
BioEssays : news and reviews in molecular, cellular and developmental biology
Speculating on the Roles of Nuclear Speckles: How RNA-Protein Nuclear Assemblies Affect Gene Expression
Nature Reviews, Microbiology
Formation and function of bacterial organelles
Jill Bouchard
Contributing editor, Condensates.com
The authors cover both membrane-bound and membrane-less organelles...should be a good read.
Virology journal
The role of host eIF2α in viral infection
Jill Bouchard
Contributing editor, Condensates.com
This review has a nice section on the various ways viruses have evolved to interact with stress granules.
bioRxiv
Structural analysis of SARS-CoV-2 genome and predictions of the human interactome
Jill Bouchard
Contributing editor, Condensates.com
Interesting–a bioinformatic analysis of the SARS-CoV-2 genome shows the RNA processing proteins are prone to phase separate and go to condensates.
PLoS Biology
Phase separation of Arabidopsis EMB1579 controls transcription, mRNA splicing, and development
Kitchen Table Talk
Christine Mayr on Condensate Networks
Molecular cell
Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity
Trends in biochemical sciences
Biomolecular Condensates in the Nucleus
Jill Bouchard
Contributing editor, Condensates.com
Need an update on what's new with nuclear condensates? This will be a good place to start!
BioMed research international
Rice stripe virus p2 Colocalizes and Interacts with Arabidopsis Cajal Bodies and Its Domains in Plant Cells
Jill Bouchard
Contributing editor, Condensates.com
Here's a plant virus that targets Cajal bodies in it's infection strategy.
Proceedings of the National Academy of Sciences of the United States of America
Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation
Nature communications
HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains
Jill Bouchard
Contributing editor, Condensates.com
It looks like HIV hits nuclear speckles hard in order to get into the host genome.
Molecules (Basel, Switzerland)