Current Opinion in Genetics & Development
Most Recent
Molecular cell
Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation
Jill Bouchard
Contributing editor, Condensates.com
It looks like a lot of important telomere biochemistry happens in and around Cajal bodies.
Research Associate(m/f/d) – New Target Discovery
Dewpoint Therapeutics | Dresden, Germany
ApplybioRxiv
Molecular determinants of liquid demixing and amyloidogenesis in human CPEB3
Jill Bouchard
Contributing editor, Condensates.com
Cool--this is a close biophysical look at how condensates play a role in long-term memory formation.
BMC biology
Unraveling the Molecular Interactions Involved in Phase Separation of Glucocorticoid Receptor
Cold Spring Harbor symposia on quantitative biology
Subcellular Spatial Transcriptomes: Emerging Frontier for Understanding Gene Regulation
Jill Bouchard
Contributing editor, Condensates.com
Obviously, LLPS is one of the recent developments that is reshaping our understanding of gene regulation. ;)
Nature plants
DHH1/DDX6-like RNA Helicases Maintain Ephemeral Half-Lives of Stress-Response mRNAs
BioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
bioRxiv
Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change
BioRxiv
Nuclear phosphatidylinositol 3,4,5-trisphosphate interactome uncovers an enrichment in nucleolar proteins
Jill Bouchard
Contributing editor, Condensates.com
It's cool to see important lipid signaling molecules show up in condensates!
Molecular biology of the cell
Synergistic Interactions Between Cajal Bodies and the miRNA Processing Machinery
Nature Methods
Cell Biology Befriends Soft Matter Physics
Scientific reports
Comparative Analysis of MACROD1, MACROD2 and TARG1 Expression, Localisation and Interactome
Jill Bouchard
Contributing editor, Condensates.com
These proteins appear to be important regulators of nucleoli and stress granules.
bioRxiv
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
bioRxiv
Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation
bioRxiv
Stress granules display bistable dynamics modulated by Cdk
Jill Bouchard
Contributing editor, Condensates.com
Perhaps this modulation of stress granules will be therapeutically relevant for figuring out how to dissolve them.
Kitchen Table Talk
Amy Gladfelter on RNA-Driven Phase Separation
Scientific Reports
Super-resolution in Situ Analysis of Active Ribosomal DNA Chromatin Organization in the Nucleolus
Jill Bouchard
Contributing editor, Condensates.com
The architecture of nucleoli is fascinating, and we'll get so many more insights into how they work as more awesome methods like this come out.
Kitchen Table Talk
Liam Holt on Crowding and Compression
Cell
Unblending of Transcriptional Condensates in Human Repeat Expansion Disease
Jill Bouchard
Contributing editor, Condensates.com
It's not surprising that repeat expansions alter the phase separation and subsequent material properties of condensates. The discussion on how poly-alanine (and other IDR) tracts contribute to disease will be super useful going forward.