Trends in biochemical sciences
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions
Jill Bouchard
Contributing editor, Condensates.com
This review covers the role of G-quads in phase separation.
Most Recent
Stem Cell Reports
Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization
Jill Bouchard
Contributing editor, Condensates.com
This is a fascinating review about the role of nucleoli in regulating transcription and chromatin structure in stem cells.
BioEssays : news and reviews in molecular, cellular and developmental biology
RNA-protein interactions: Central players in coordination of regulatory networks
Current opinion in genetics & development
Nuclear mechanisms of gene expression control: pre-mRNA splicing as a life or death decision
Jill Bouchard
Contributing editor, Condensates.com
How do nuclear speckles play a role in splicing? Read this to find out.
Developmental cell
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
Dec
10
Emerging Topics in Biomolecular Magnetic Resonance: Mei Hong & Markus Zweckstetter
Thursday, December 10, 2020
Journal of Biochemistry
A dynamic actin-dependent nucleoskeleton and cell identity
The EMBO journal
Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages
Jill Bouchard
Contributing editor, Condensates.com
It looks like the condensates in infected macrophages get all messed up. Check out this paper to find out more.
eLife
Viral-induced alternative splicing of host genes promotes influenza replication
Jill Bouchard
Contributing editor, Condensates.com
It looks like nuclear speckles may be a key location for the splicing agents that help this virus with replication.
International journal of molecular sciences
Liquid-Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus-Host Interactions
Nature communications
Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
Wellcome open research
A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation
Jill Bouchard
Contributing editor, Condensates.com
Based on their findings, the authors suggest phosphorylation plays a role in targeting proteins to membraneless organelles in certain types of parasites.
Stem cell reports
Chromatin-Associated Membraneless Organelles in Regulation of Cellular Differentiation
Cell Reports
Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast
Nature
RNA nucleation by MSL2 induces selective X chromosome compartmentalization
Jill Bouchard
Contributing editor, Condensates.com
It looks like low complexity sequences and non-coding RNA are important for condensing chromosomes. I wonder if interactions are important in chromatin condensates?
bioRxiv
Biomolecular Condensation Drives Leukemia Caused by NUP98-Fusion Proteins
bioRxiv
SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNPs from Cajal bodies to nuclear speckles for spliceosome assembly
Jill Bouchard
Contributing editor, Condensates.com
This paper implicates nuclear speckles and cajal bodies in the cellular dysfunctions that may lead to deaf-blindness.
bioRxiv
Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation
Journal of the American Chemical Society
Folding of an Intrinsically Disordered Iron-Binding Peptide in Response to Sedimentation Revealed by Cryo-EM
Jill Bouchard
Contributing editor, Condensates.com
Here's an interesting new method to look at IDPs and minerals in solid formations. I wonder if it could be applied to more liquid- or gel-like condensates?
Nature genetics