bioRxiv
Most Recent
mSphere
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7
Jill Bouchard
Editor in Chief, Condensates.com
The authors implicate stress granules and potentially other cellular compartments in mediating antiviral effects.
A Newfound Source of Cellular Order in the Chemistry of Life
Nature communications
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response
Jill Bouchard
Editor in Chief, Condensates.com
Here's the 2nd paper that came out in the same day about p62 bodies. If you don't know much about them (no judging, I didn't either ;), these papers might help you get up to speed!
EMBO reports
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling
Jill Bouchard
Editor in Chief, Condensates.com
Have you heard about p62 bodies yet? This is the first of two papers published on the same day about them.
bioRxiv
Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
Journal of molecular biology
Biochemical timekeeping via reentrant phase transitions
bioRxiv
A comprehensive motifs-based interactome of the C/EBPα transcription factor
Jill Bouchard
Editor in Chief, Condensates.com
The authors point out that this method may be a useful for identifying important interactions and PTM regulations of IDPs involved in condensates.
bioRxiv
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells
Virus research
Double-edged Role of PML Nuclear Bodies during Human Adenovirus Infection
STAR protocols
Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation
Cell chemical biology
Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor
Jill Bouchard
Editor in Chief, Condensates.com
The main inhibitor they found also increases the formation of P bodies.
International journal of molecular sciences
Intrinsic Disorder in Plant Transcription Factor Systems: Functional Implications
Postdoctoral Research Fellow 4D Nucleome Full-time
Johns Hopkins University | Baltimore, MD, USA
ApplyGenome research
TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes
Jill Bouchard
Editor in Chief, Condensates.com
Who knew nuclear speckles had such a large role in regulating gene expression?!
The Journal of biological chemistry
Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo
Jill Bouchard
Editor in Chief, Condensates.com
This essential transcription factor phase separates and its IDR is responsible for its localization to nucleoli.
Science
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
Cell Proliferation
Super enhancers-Functional cores under the 3D genome
Communications biology
Biomolecular condensates as arbiters of biochemical reactions inside the nucleus
Immunity
It’s a Phase That EBF1 Is Going Through
Jill Bouchard
Editor in Chief, Condensates.com
Here's the Preview article for an Immunity paper about a prion-like domain with a pioneering function in transcription.