Amy Gladfelter on RNA-Driven Phase Separation

Amy Gladfelter joined Dewpoint scientists (virtually) on May 5, giving a beautiful talk as part of our Kitchen Table Talk series. Amy is a professor in the Biology Department at UNC, Chapel Hill, with an interest in how cells are organized in time and space. Amy studies both fungal and mammalian systems using quantitative live cell microscopy and a variety of computational, genetic, and biochemical approaches.

Amy’s work has been trail-blazing about the essential role that RNA plays in liquid-liquid phase separation. In her talk she highlights many fascinating aspects of the function of RNA in the architecture of biomolecular condensates. Enjoy!



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TRANSCRIPT
Mark Murcko (00:00):
We can go ahead and get started. So, Amy Gladfelter, great to have you giving us a seminar on your recent work. Obviously, you’ve been in the condensate game as long as just about anybody and have done some pioneering work and wonderful to have a chance to hear from you.

Amy Gladfelter (00:26):
Great. Thanks Mark. It’s really fantastic to be here. I’m just going to get my-

Mark (00:33):
Yeah. Good.

Amy Gladfelter (00:33):
screen set up.

Mark (00:36):
Perfect.

Amy Gladfelter (00:38):
Okay. So today I’m really going to be focusing on an area of condensate biology that takes the perspective of RNA, which is a major feature of many condensates, and one of the main things we are thinking about in the condensate world. I often get asked how did I start thinking about condensates? What got me into this field and this business? And it really came out of a longstanding curiosity and interest in a very special kind of cell, which is a syncytial cell. I’ll be talking about a couple of different types of syncytia today…

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