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"This is the News and Views discussing the implications of the findings in Guy et al, Nature Immunology (2022)."

LAG3 disrupts the TCR signal by local acidification

"Local change in pH, driven by clustering of LAG3 acidic stretches in its cytoplasmic disordered region, lead to dissociation of Lck/CD4 or CD8 signaling clusters. This is a novel mechanism controlling the T-cell signalling."

LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation

"Who needs membranes when you can form vesicles by complex coacervation of proteins with RNA? Another excellent paper by Banerjee lab."

Phase Transition of RNA-protein Complexes into Ordered Hollow Condensates