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VIDEO: Karla Neugebauer on Nascent RNA and Biomolecular Condensation in the Cell Nucleus

The Dewpoint scientists were thrilled to welcome Karla Neugebauer and the condensates community to the Dresden and Boston kitchen tables on May 4th for a fantastic discussion as part of the Kitchen Table Talk series. Karla is currently the Director at the Yale Center for RNA Science and Medicine and has been studying many processes involving RNA throughout her career, including transcription, splicing, and export.

She spent several years as a Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden, Germany, where I had the pleasure of working as a postdoc in her lab. I had my first taste of data science and condensates while in Karla’s group. In her talk below, she covers the role that membraneless compartments play in RNA processing. I hope you enjoy the lively discussion as much as we did, and if you would like to join the conversation feel free to email Karla at

Karla Neugebauer on Nascent RNA and Biomolecular Condensation in the Cell Nucleus

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Antonio Domingues (00:00:00):
It’s my pleasure to be host to Karla Neugebauer, whom I know from the MPI-CBG here in Dresden, which is also the lab or the institute where one of our founders is based in. I met Karla because I was a postdoc there. It’s very nice to have her here. I’m only a data scientist because of Karla pushing me to work more in the computer, and get away from pipette. I think that tells you something about myself. Karla is now a director at the Yale Center for RNA Science and Medicine.

Antonio Domingues (00:00:37):
This makes a lot of sense, this name, because she’s been working on RNA pretty much all her career, nearly the entire life cycle of RNA, going from transcription, splicing, export. I think you only missed probably degradation, because that doesn’t-

Karla Neugebauer (00:00:55):
I never worked on translation, although I admire translation.

Antonio Domingues (00:00:56):
Exactly. Relevant for this talk and for condensate is that she’s from… Since I was in the lab, and probably earlier, she’s been an enthusiast in membraneless compartments. More than me, In fact, I didn’t see the potential. She’s going to talk a lot about her work and especially the role that the membraneless compartments play into RNA processing and vice versa, I think, as well. I think Cajal bodies has been something that has been working on a long time, but I’ll just leave the floor now for Karla.

Karla Neugebauer (00:01:31):
Okay, great. Thanks, Antonio. Can everyone hear me? Put some thumbs up. Yeah. Jill, it looks like you can see me.

Jill Bouchard (00:01:38):
You sound great.

Karla Neugebauer (00:01:39):
Awesome. It’s really a pleasure to have been invited to the Kitchen Table Talks. Initially, I had asked to go to Boston to be in person, but now I get to be in Dresden in person, which is fun. I’m really looking forward to telling you about our work in the nucleus, and also to get some feedback. We’re at a point where we have lots of new data that I’m going to be showing, and also a lot of choice points in the road about what’s most important to learn about condensation in the nucleus. What I’m showing on my title slide here is a HeLa cell nucleus that I’ve labeled with BrUTP in a run-on transcription experiment…

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